Ciita Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ciita
class II transactivator
MGI:108445

46 phenotypes from 7 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ciita^m1Btlr/Ciita^m1Btlr C57BL/6J-Ciita^m1Btlr	abnormal CD4-positive T cell differentiation	J:221483
	abnormal CD8-positive, alpha-beta T cell differentiation	J:221483
	impaired humoral immune response	J:221483
Ciita^tm1.1Dim/Ciita^tm1.1Dim involves: 129S2/SvPas * C57BL/6 * SJL	abnormal level of surface class II molecules	J:51885
	decreased CD4-positive, alpha-beta T cell number	J:51885
	decreased dendritic cell number	J:51885
Ciita^tm1Adm/Ciita⁺ involves: 129S1/Sv * C57BL/6	abnormal immune system physiology	J:117111
Ciita^tm1Adm/Ciita^tm1Adm involves: 129S1/Sv * C57BL/6	abnormal immune system physiology	J:117111
Ciita^tm1Ccum/Ciita^tm1Ccum involves: 129S2/SvPas	no abnormal phenotype detected	J:111611
Ciita^tm1Ccum/Ciita^tm1Ccum involves: 129S2/SvPas * C57BL/6	abnormal level of surface class II molecules	J:67941
Ciita^tm1Ccum/Ciita^tm1Ccum involves: 129S2/SvPas * C57BL/6J	abnormal B cell physiology	J:96421
	abnormal CD4-positive, alpha-beta T cell physiology	J:31601
	abnormal cytokine secretion	J:64283
	abnormal dendritic cell physiology	J:96421
	abnormal level of surface class II molecules	J:31601, J:96421
	abnormal lymphocyte physiology	J:96421
	abnormal MHC II cell surface expression on macrophages	J:31601
	abnormal popliteal lymph node morphology	J:64283
	abnormal susceptibility to infection	J:64283
	abnormal T cell differentiation	J:64283
	abnormal T cell physiology	J:31601
	decreased CD4-positive, alpha-beta T cell number	J:31601
	decreased susceptibility to parasitic infection	J:64283
	decreased T cell proliferation	J:31601
	increased CD4-positive, alpha-beta T cell number	J:64283
	increased CD8-positive, alpha-beta T cell number	J:64283
	increased susceptibility to parasitic infection	J:64283
Ciita^tm1Ccum/Ciita^tm1Ccum NOD.129S2(B6)-Ciita^tm1Ccum	abnormal circulating glucose level	J:106081
	abnormal inflammatory response	J:106081
	abnormal level of surface class II molecules	J:106081
	abnormal T cell differentiation	J:106081
	decreased CD4-positive, alpha-beta T cell number	J:106081
	decreased susceptibility to autoimmune diabetes	J:107051
	increased CD8-positive, alpha-beta T cell number	J:106081
	insulitis	J:107051
	pancreas inflammation	J:106081
	periinsulitis	J:106081
Ciita^tm1Jpyt/Ciita^tm1Jpyt B6.129P2-Ciita^tm1Jpyt	abnormal T-helper 1 physiology	J:125654
Ciita^tm1Jpyt/Ciita^tm1Jpyt B6.129P2-Ciita^tm1Jpyt	decreased susceptibility to experimental autoimmune encephalomyelitis	J:125654
Ciita^tm1Jpyt/Ciita^tm1Jpyt involves: 129P2/OlaHsd * C57BL/6J	abnormal T cell subpopulation ratio	J:57100
	decreased CD4-positive, alpha-beta T cell number	J:57100
	decreased IgG level	J:57100
	increased CD8-positive, alpha-beta T cell number	J:57100
	increased double-positive T cell number	J:57100
	increased IgM level	J:57100
Ciita^tm1Wrth/Ciita^tm1Wrth B6.129P2-Ciita^tm1Wrth	normal immune system phenotype	J:117111
Ciita^tm1Wrth/Ciita^tm1Wrth involves: 129P2/OlaHsd * C57BL/6	abnormal trabecular bone morphology	J:233241
	absent CD4-positive, alpha-beta T cells	J:233241
	decreased bone trabecula number	J:233241
	decreased trabecular bone volume	J:233241
	increased bone resorption	J:233241
	increased bone trabecular spacing	J:233241
	increased circulating type I collagen C-terminal telopeptide level	J:233241
	increased osteoclast cell number	J:233241
	osteoporosis	J:233241
Ciita^tm2Wrth/Ciita^tm2Wrth B6.129P2-Ciita^tm2Wrth	normal immune system phenotype	J:117111
Ciita^tm2Wrth/Ciita^tm2Wrth involves: 129P2/OlaHsd * C57BL/6	abnormal immunoglobulin level	J:92170
	decreased CD4-positive, alpha-beta T cell number	J:92170

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