Angpt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Angpt1
angiopoietin 1
MGI:108448

20 phenotypes from 6 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Angpt1^tm1.1Seq/Angpt1^tm1.2Seq Tg(Nphs1-cre)1Seq/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal renal glomerulus morphology	J:174022
Angpt1^tm1.1Seq/Angpt1^tm1.2Seq Tg(Pdgfrb-cre)#Rha/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal renal glomerulus morphology	J:174022
Angpt1^tm1.1Yona/Angpt1^tm1.1Yona Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae	abnormal retina blood vessel morphology	J:213456
	decreased astrocyte number	J:213456
	increased susceptilbility to retina ischemic injury	J:213456
	increased vascular permeability	J:213456
Angpt1^tm1Sato/Angpt1^tm1Sato involves: 129P2/OlaHsd * C57BL/6	abnormal endocardium morphology	J:37459
	abnormal vascular development	J:37459
	abnormal vascular endothelial cell morphology	J:37459
	abnormal vitelline vasculature morphology	J:37459
	absent myocardial trabeculae	J:37459
	decreased angiogenesis	J:37459
	delayed heart development	J:37459
	embryonic lethality during organogenesis, complete penetrance	J:37459
	failure of vascular branching	J:37459
Angpt1^tm2Sato/Angpt1^tm2Sato involves: 129P2/OlaHsd * C57BL/6	abnormal endocardium morphology	J:37459
	abnormal vascular development	J:37459
	abnormal vascular endothelial cell morphology	J:37459
	abnormal vitelline vasculature morphology	J:37459
	absent myocardial trabeculae	J:37459
	decreased angiogenesis	J:37459
	delayed heart development	J:37459
	embryonic lethality during organogenesis, complete penetrance	J:37459
	failure of vascular branching	J:37459
Tg(KRT14-Angpt1)1Gdy/0 Not Specified	abnormal capillary branching pattern	J:50482
	abnormal capillary morphology	J:50482, J:131824
	abnormal skin vasculature morphology	J:50482
	abnormal venule morphology	J:50482
	reddish skin	J:50482
	varicose veins	J:50482

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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