Acaca Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acaca
acetyl-Coenzyme A carboxylase alpha
MGI:108451

24 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acaca^tm1.1Jkus/Acaca^tm1.1Jkus involves: 129X1/SvJ * C57BL/6J	embryonic growth retardation	J:118861
	embryonic lethality during organogenesis	J:118861
Acaca^tm1Dejs/Acaca^tm1Dejs Tg(Cd4-cre)1Cwi/? involves: C57BL/6 * DBA/2	abnormal lipid metabolism	J:209886
	abnormal T cell physiology	J:209886
	decreased memory T cell number	J:209886
	decreased T cell number	J:209886
	normal immune system phenotype	J:209886
Acaca^tm1Jkus/Acaca^tm1Jkus Tg(Fabp1-cre)1Mmt/0 involves: 129X1/SvJ * C57BL/6J * SJL	abnormal lipid homeostasis	J:118861
	decreased liver triglyceride level	J:118861
	increased circulating aspartate transaminase level	J:118861
Acaca^tm1Sjw/Acaca^tm1Sjw involves: 129S7/SvEvBrd * C57BL/6J	decreased embryo size	J:101150
	embryonic growth arrest	J:101150
	embryonic lethality between implantation and somite formation, complete penetrance	J:101150
Acaca^tm2Sjw/Acaca^tm2Sjw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S7/SvEvBrd * C57BL/6J * FVB	abnormal enzyme/coenzyme activity	J:110200
	abnormal glucose homeostasis	J:110200
	abnormal lipid level	J:110200
	abnormal liver physiology	J:110200
	decreased circulating free fatty acids level	J:110200
	decreased circulating ketone body level	J:110200
	decreased fatty acids level	J:110200
	decreased liver triglyceride level	J:110200
	decreased susceptibility to hepatic steatosis	J:110200
	hyperglycemia	J:110200
	increased circulating free fatty acids level	J:110200
	increased circulating insulin level	J:110200

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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