Acaca Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acaca
acetyl-Coenzyme A carboxylase alpha
MGI:108451

24 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acaca^tm1.1Jkus/Acaca^tm1.1Jkus involves: 129X1/SvJ * C57BL/6J	embryonic growth retardation	J:118861
	embryonic lethality during organogenesis	J:118861
Acaca^tm1Dejs/Acaca^tm1Dejs Tg(Cd4-cre)1Cwi/? involves: C57BL/6 * DBA/2	abnormal lipid metabolism	J:209886
	abnormal T cell physiology	J:209886
	decreased memory T cell number	J:209886
	decreased T cell number	J:209886
	normal immune system phenotype	J:209886
Acaca^tm1Jkus/Acaca^tm1Jkus Tg(Fabp1-cre)1Mmt/0 involves: 129X1/SvJ * C57BL/6J * SJL	abnormal lipid homeostasis	J:118861
	decreased liver triglyceride level	J:118861
	increased circulating aspartate transaminase level	J:118861
Acaca^tm1Sjw/Acaca^tm1Sjw involves: 129S7/SvEvBrd * C57BL/6J	decreased embryo size	J:101150
	embryonic growth arrest	J:101150
	embryonic lethality between implantation and somite formation, complete penetrance	J:101150
Acaca^tm2Sjw/Acaca^tm2Sjw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S7/SvEvBrd * C57BL/6J * FVB	abnormal enzyme/coenzyme activity	J:110200
	abnormal glucose homeostasis	J:110200
	abnormal lipid level	J:110200
	abnormal liver physiology	J:110200
	decreased circulating free fatty acids level	J:110200
	decreased circulating ketone body level	J:110200
	decreased fatty acids level	J:110200
	decreased liver triglyceride level	J:110200
	decreased susceptibility to hepatic steatosis	J:110200
	hyperglycemia	J:110200
	increased circulating free fatty acids level	J:110200
	increased circulating insulin level	J:110200

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24