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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dab1
disabled 1
MGI:108554
58 phenotypes from 15 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dab1scm-2J/Dab1scm-2J
MRL.129P2(B6)-B2mtm1Unc/Dcr 		cachexia J:163447
postnatal lethality, incomplete penetrance J:163447
prenatal lethality, incomplete penetrance J:163447
tremors J:163447
Dab1scm-3J/Dab1scm-3J
B6.Cg-Dab1scm-3J/J 		abnormal hippocampus layer morphology J:149813
abnormal motor coordination/balance J:149813
absent cerebellar foliation J:149813
cerebellum hypoplasia J:149813
decreased body size J:149813
impaired righting response J:149813
postnatal lethality, incomplete penetrance J:149813
Dab1scm-4J/Dab1scm-4J
CBA/J-Dab1scm-4J/GrsrJ 		abnormal bone marrow morphology J:153275
abnormal brain morphology J:153275
abnormal gait J:153275
decreased body size J:153275
postnatal lethality, incomplete penetrance J:153275
thymus atrophy J:153275
tremors J:153275
Dab1scm-5J/Dab1scm-5J
BKS(Cg)-Dab1scm-5J/GrsrJ 		abnormal cerebellar layer morphology J:209638
abnormal cerebral cortex morphology J:209638
abnormal gait J:209638
abnormal hippocampus morphology J:209638
abnormal motor coordination/balance J:209638
ataxia J:209638
impaired righting response J:209638
lethality at weaning, complete penetrance J:209638
postnatal lethality, incomplete penetrance J:209638
thin body J:209638
weakness J:209638
Dab1scm-6J/Dab1scm-6J
involves: C57BL/6 		abnormal cerebellar foliation J:211099
abnormal cerebellar granule layer morphology J:211099
abnormal cerebellar Purkinje cell layer J:211099
abnormal cerebral cortex morphology J:211099
abnormal hippocampus layer morphology J:211099
abnormal hippocampus morphology J:211099
abnormal stratification in cerebral cortex J:211099
ataxia J:211099
cerebellum hypoplasia J:211099
decreased body size J:211099
impaired balance J:211099
impaired righting response J:211099
postnatal lethality, complete penetrance J:211099
Dab1scm/Dab1scm
involves: C3H * C57BL/6J 		abnormal cone electrophysiology J:71970
abnormal retina inner nuclear layer morphology J:71970
abnormal retina rod bipolar cell morphology J:71970
abnormal rod electrophysiology J:71970
Dab1scm/Dab1scm
involves: C3HeB/FeJ * DC/Le 		abnormal cerebellar foliation J:37166
abnormal cerebellar Purkinje cell layer J:37166
abnormal cerebral cortex morphology J:37166
abnormal dentate gyrus morphology J:37166
abnormal gait J:37166
abnormal hippocampus morphology J:37166
abnormal hippocampus pyramidal cell morphology J:37166
abnormal motor coordination/balance J:37166
abnormal stratification in cerebral cortex J:37166
decreased body size J:37166
decreased survivor rate J:37166
male infertility J:37166
postnatal lethality J:37166
small cerebellum J:37166
tremors J:37166
Dab1tm1.1Bwh/Dab1tm1.1Bwh
involves: 129S4/SvJaeSor * C57BL/6 		abnormal nervous system morphology J:132599
ataxia J:132599
Dab1tm1.1Mull/Dab1tm1.1Mull
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:174747
Dab1tm1.1Mull/Dab1tm1.1Mull
involves: 129P2/OlaHsd * C57BL/6J 		abnormal neuronal migration J:174747
Dab1tm1.1Mull/Dab1tm1.1Mull
Cux2tm2.1(cre)Mull/Cux2+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL 		abnormal neocortex morphology J:174747
abnormal neuronal migration J:174747
normal nervous system phenotype J:174747
Dab1tm1.1Mull/Dab1tm1.1Mull
Neurod6tm1(cre)Kan/Neurod6+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cortical marginal zone morphology J:174747
abnormal neuronal migration J:174747
abnormal telencephalon development J:174747
absent subplate J:174747
Dab1tm1.1Mull/Dab1tm1.1Mull
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL 		abnormal cortical marginal zone morphology J:174747
abnormal neuronal migration J:174747
abnormal telencephalon development J:174747
absent subplate J:174747
ataxia J:174747
tremors J:174747
Dab1tm1Bwh/Dab1+
involves: 129S4/SvJaeSor * C57BL/6 		abnormal cerebellar foliation J:132599
small cerebellum J:132599
Dab1tm1Bwh/Dab1tm1Bwh
involves: 129S4/SvJaeSor * C57BL/6 		abnormal brain morphology J:132599
abnormal cerebellar foliation J:132599
abnormal cerebellar Purkinje cell layer J:132599
normal behavior/neurological phenotype J:132599
ectopic Purkinje cell J:132599
small cerebellum J:132599
Dab1tm1Cpr/Dab1tm1Cpr
either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal neuronal precursor cell migration J:121846
abnormal olfactory bulb granule cell layer morphology J:121846
abnormal olfactory bulb morphology J:121846
abnormal postnatal subventricular zone morphology J:121846
abnormal rostral migratory stream morphology J:121846
Dab1tm1Cpr/Dab1tm1Cpr
involves: 129/Sv * C57BL/6 		abnormal cerebral cortex morphology J:91679
Dab1tm1Cpr/Dab1tm1Cpr
involves: 129S4/SvJaeSor 		abnormal cortical marginal zone morphology J:74239
abnormal dentate gyrus morphology J:74239
abnormal hippocampus pyramidal cell layer J:74239
Dab1tm1Cpr/Dab1tm1Cpr
involves: 129S4/SvJaeSor * C57BL/6 		premature death J:79475
Dab1tm1Cpr/Dab1tm2Cpr
involves: 129S4/SvJaeSor * C57BL/6 		ataxia J:79475
Dab1tm1Cpr/Dab1tm3.1Cpr
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal cortical marginal zone morphology J:74239
abnormal hippocampus pyramidal cell layer J:74239
abnormal neuronal migration J:74239
normal nervous system phenotype J:74239
Dab1tm1Cpr/Dab1tm4Cpr
involves: 129/Sv * C57BL/6 		abnormal cortical marginal zone morphology J:91679
Dab1tm1Cpr/Dab1tm6Cpr
involves: 129S4/SvJaeSor * C57BL/6 		abnormal cortical marginal zone morphology J:145031
abnormal stratification in cerebral cortex J:145031
Dab1tm2Cpr/Dab1tm2Cpr
either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal postnatal subventricular zone morphology J:121846
abnormal rostral migratory stream morphology J:121846
Dab1tm2Cpr/Dab1tm2Cpr
involves: 129S4/SvJaeSor 		abnormal cortical marginal zone morphology J:74239
abnormal dentate gyrus morphology J:74239
abnormal hippocampus pyramidal cell layer J:74239
Dab1tm2Cpr/Dab1tm2Cpr
involves: 129S4/SvJaeSor * C57BL/6 		abnormal brain morphology J:79475
abnormal cerebellar granule layer morphology J:79475
abnormal cerebellar Purkinje cell layer J:79475
abnormal cerebral cortex morphology J:79475
abnormal cortical marginal zone morphology J:79475
abnormal dentate gyrus morphology J:79475
abnormal hippocampus CA2 region morphology J:79475
abnormal tail movements J:79475
absent cerebellar foliation J:79475
ataxia J:79475
impaired balance J:79475
premature death J:79475
small cerebellum J:79475
Dab1tm3.1Cpr/Dab1tm3.1Cpr
involves: 129S4/SvJaeSor * C57BL/6J 		normal nervous system phenotype J:74239
Dab1tm4Cpr/Dab1tm4Cpr
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:91679
Dab1tm5Cpr/Dab1tm5Cpr
involves: 129S4/SvJaeSor * C57BL/6 		abnormal cerebellum morphology J:145031
abnormal cerebral cortex morphology J:145031
abnormal cortical marginal zone morphology J:145031
abnormal hippocampus morphology J:145031
abnormal stratification in cerebral cortex J:145031
abnormal subplate morphology J:145031
abnormal telencephalon development J:145031
ectopic Purkinje cell J:145031
small cerebellum J:145031
Dab1tm5Cpr/Dab1tm6Cpr
involves: 129S4/SvJaeSor * C57BL/6 		normal nervous system phenotype J:145031
Dab1tm6Cpr/Dab1tm6Cpr
involves: 129S4/SvJaeSor * C57BL/6 		abnormal cerebellum morphology J:145031
abnormal cerebral cortex morphology J:145031
abnormal cortical marginal zone morphology J:145031
abnormal hippocampus morphology J:145031
abnormal stratification in cerebral cortex J:145031
abnormal subplate morphology J:145031
abnormal telencephalon development J:145031
ectopic Purkinje cell J:145031
small cerebellum J:145031
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory