Fzd5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fzd5
frizzled class receptor 5
MGI:108571

31 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fzd5^{tm1.1(KOMP)Vlcg}/Fzd5^{tm1.1(KOMP)Vlcg} C57BL/6N-Fzd5^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
Fzd5^tm1Cle/Fzd5^tm1Cle involves: 129P2/OlaHsd	ectopic Paneth cells	J:98680
Fzd5^tm1Cle/Fzd5^tm1Cle Tg(Six3-cre)69Frty/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	normal vision/eye phenotype	J:136314
Fzd5^tm1Mmt/Fzd5^tm1Cle Tg(Six3-cre)69Frty/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	abnormal eye physiology	J:142601
	abnormal retina apoptosis	J:142601
	abnormal retina layer morphology	J:142601
	abnormal vascular regression	J:142601
	disorganized retina ganglion layer	J:142601
	increased cornea thickness	J:142601
	increased total retina thickness	J:142601
	microphthalmia	J:142601
	retina detachment	J:142601
	retina fold	J:142601
	small lens	J:142601
	normal vision/eye phenotype	J:142601
	vitreous body deposition	J:142601
Fzd5^tm1Mmt/Fzd5^tm1Mmt involves: 129X1/SvJ	abnormal eye physiology	J:136314
	abnormal lens development	J:136314
	abnormal optic cup morphology	J:136314
	abnormal optic vesicle formation	J:136314
	increased retina apoptosis	J:136314
Fzd5^tm1Mmt/Fzd5^tm1Mmt involves: 129X1/SvJ * C57BL/6	abnormal placental labyrinth vasculature morphology	J:52605
	abnormal visceral yolk sac morphology	J:52605
	abnormal vitelline vascular remodeling	J:52605
	disorganized yolk sac vascular plexus	J:52605
	hemorrhage	J:52605
	pale yolk sac	J:52605
	prenatal lethality, complete penetrance	J:52605
Fzd5^tm1Nat/Fzd5^tm1Nat involves: 129S1/Sv * 129X1/SvJ * C57BL/6	prenatal lethality, complete penetrance	J:136390
Fzd5^tm1Nat/Fzd5^tm2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	abnormal thalamus morphology	J:136390
	decreased body size	J:136390
	decreased body weight	J:136390
	impaired coordination	J:136390
	retina degeneration	J:136390
Fzd5^tm1Nat/Fzd5^tm2Nat Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	abnormal thalamus morphology	J:136390

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24