Hnf4a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hnf4a
hepatic nuclear factor 4, alpha
MGI:109128

63 phenotypes from 11 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hnf4a^tm1(cre)Sdv/Hnf4a⁺ involves: 129S/SvEv * CD-1	no abnormal phenotype detected	J:92294
Hnf4a^tm1.1Gonz/Hnf4a^tm1.1Gonz Tg(Alb1-cre)1Dlr/0 involves: 129X1/SvJ * FVB/N	abnormal hepatocyte mitochondrial morphology	J:67396
	abnormal hepatocyte morphology	J:67396
	abnormal liver morphology	J:67396
	decreased circulating cholesterol level	J:67396
	decreased circulating HDL cholesterol level	J:67396
	decreased circulating triglyceride level	J:67396
	enlarged liver	J:67396
	premature death	J:67396
	weight loss	J:67396
Hnf4a^tm1.1Gonz/Hnf4a^tm1.1Gonz Tg(Ins2-cre)25Mgn/0 involves: 129X1/SvJ * C57BL/6 * DBA	abnormal channel response	J:108652
	decreased circulating insulin level	J:108652
	impaired glucose tolerance	J:108652
Hnf4a^tm1.1Mwei/Hnf4a^tm1.1Mwei involves: 129S2/SvPas * BALB/c * C57BL/6	impaired glucose tolerance	J:106993
Hnf4a^tm1.2Gonz/Hnf4a^tm1.2Gonz involves: 129X1/SvJ * FVB/N	preweaning lethality, complete penetrance	J:67396
Hnf4a^{tm1b(EUCOMM)Hmgu}/Hnf4a⁺ C57BL/6N-Hnf4a^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	cataract	J:211773
	decreased body weight	J:211773
	decreased circulating creatinine level	J:211773
	enlarged thyroid gland	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating calcium level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased total retina thickness	J:211773
	persistence of hyaloid vascular system	J:211773
Hnf4a^tm1Dnl/Hnf4a^tm1Dnl either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	abnormal ectoderm development	J:21129
	abnormal embryo development	J:21129
	abnormal embryonic tissue morphology	J:21129
	abnormal extraembryonic tissue morphology	J:21129
	abnormal gastrulation	J:21129
	abnormal primitive streak formation	J:21129
	absent allantois	J:21129
	absent amnion	J:21129
	absent chorion	J:21129
	absent mesoderm	J:21129
	delayed gastrulation	J:21129
	embryonic growth retardation	J:21129
	embryonic lethality, complete penetrance	J:21129
	increased ectoderm apoptosis	J:21129
	small visceral yolk sac	J:21129
Hnf4a^tm1Dnl/Hnf4a^tm1Dnl involves: 129S4/SvJae * C57BL/6	decreased embryo size	J:50810
Hnf4a^tm1Dnl/Hnf4a^tm1Dnl involves: 129S4/SvJae * C57BL/6	increased embryonic tissue cell apoptosis	J:50810
Hnf4a^tm1Gonz/Hnf4a^tm1Gonz involves: 129X1/SvJ	preweaning lethality, complete penetrance	J:67396
Hnf4a^tm1Mwei/Hnf4a^tm1Mwei involves: 129S2/SvPas * C57BL/6	no abnormal phenotype detected	J:106993
Hnf4a^tm1Sad/Hnf4a^tm1Sad involves: 129S1/Sv * 129X1/SvJ * CD-1	no abnormal phenotype detected	J:75121
Hnf4a^tm1Sad/Hnf4a^tm1Sad Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney development	J:266356
	abnormal kidney morphology	J:266356
	abnormal proximal convoluted tubule morphology	J:266356
	increased urine glucose level	J:266356
	increased urine phosphate level	J:266356
	nephrocalcinosis	J:266356
	polydipsia	J:266356
	polyuria	J:266356
	small kidney	J:266356
Hnf4a^tm1Sad/Hnf4a^tm1Sad Tg(Alb1-cre)1Khk/0 involves: C57BL/6 * SJL	abnormal hepatocyte morphology	J:84076
	abnormal liver development	J:84076
	abnormal liver morphology	J:84076
	decreased liver glycogen level	J:84076
	dissociated hepatocytes	J:84076
Hnf4a^tm2.1Mwei/Hnf4a^tm2.1Mwei involves: 129S2/SvPas * BALB/c * C57BL/6	abnormal lipid homeostasis	J:106993
	decreased circulating cholesterol level	J:106993
	decreased circulating free fatty acids level	J:106993
	decreased circulating iron level	J:106993
	decreased circulating triglyceride level	J:106993
	hepatic steatosis	J:106993
	hypokalemia	J:106993
	increased circulating bilirubin level	J:106993
	increased circulating ketone body level	J:106993
Hnf4a^tm2Mwei/Hnf4a^tm2Mwei involves: 129S2/SvPas * C57BL/6	embryonic lethality, complete penetrance	J:106993

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24