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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Epas1
endothelial PAS domain protein 1
MGI:109169
65 phenotypes from 10 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Epas1em1(IMPC)Wtsi/Epas1em1(IMPC)Wtsi
C57BL/6N-Epas1em1(IMPC)Wtsi/Wtsi 		increased total body fat amount J:211773
Epas1tm1.1Fsl/Epas1+
involves: C57BL/6 * C57BL/6NTac 		abnormal heart right ventricle pressure J:199595
increased erythrocyte cell number J:199595
increased hematocrit J:199595
increased hemoglobin content J:199595
increased leukocyte cell number J:199595
increased lymphocyte cell number J:199595
increased monocyte cell number J:199595
Epas1tm1.1Fsl/Epas1tm1.1Fsl
involves: C57BL/6 * C57BL/6NTac 		abnormal heart right ventricle pressure J:199595
increased circulating erythropoietin level J:199595
increased erythrocyte cell number J:199595
increased heart weight J:199595
increased hematocrit J:199595
increased hemoglobin content J:199595
increased leukocyte cell number J:199595
increased monocyte cell number J:199595
increased pulmonary respiratory rate J:199595
increased spleen weight J:199595
lethality, incomplete penetrance J:199595
pulmonary artery hypoplasia J:199595
thick ventricular wall J:199595
Epas1tm1.1Mcs/Epas1+
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal physiological response to hypoxia J:302384
abnormal type I cell of carotid body physiology J:302384
Epas1tm1.1Mcs/Epas1tm1.1Mcs
involves: 129X1/SvJ * FVB/N 		prenatal lethality, complete penetrance J:119731
Epas1tm1b(EUCOMM)Hmgu/Epas1+
C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H 		abnormal heart morphology J:211773
decreased hemoglobin content J:211773
Epas1tm1b(EUCOMM)Hmgu/Epas1tm1b(EUCOMM)Hmgu
C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Epas1tm1Fong/Epas1tm1Fong
involves: 129S1/Sv * 129X1/SvJ 		abnormal angiogenesis J:63415
abnormal vitelline vasculature morphology J:63415
embryonic lethality during organogenesis, complete penetrance J:63415
hemorrhage J:63415
Epas1tm1Fong/Epas1tm1Fong
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal vitelline vasculature morphology J:63415
decreased birth body size J:63415
embryonic lethality during organogenesis, incomplete penetrance J:63415
hemorrhage J:63415
postnatal lethality, incomplete penetrance J:63415
Epas1tm1Mcs/Epas1tm1.1Mcs
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129X1/SvJ * FVB/N 		abnormal hematopoietic system physiology J:119731
abnormal proerythroblast morphology J:119731
anemia J:119731
decreased erythrocyte cell number J:119731
decreased hematocrit J:119731
decreased hemoglobin content J:119731
enlarged spleen J:119731
reticulocytopenia J:119731
Epas1tm1Mcs/Epas1tm1.1Mcs
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal physiological response to hypoxia J:302384
abnormal type I cell of carotid body physiology J:302384
anemia J:302384
normal cardiovascular system phenotype J:302384
decreased hematocrit J:302384
heart left ventricle hypertrophy J:302384
Epas1tm1Mcs/Epas1tm1Mcs
Tg(CD68-icre)1Bwlx/0
involves: 129X1/SvJ * C57BL/6 		normal mortality/aging J:194598
Epas1tm1Mcs/Epas1tm1Mcs
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		decreased erythroid progenitor cell number J:186085
Epas1tm1Pec/Epas1+
involves: 129/Sv * Swiss 		abnormal cardiovascular system physiology J:83549
decreased susceptibility to injury J:83549
Epas1tm1Pec/Epas1tm1Pec
involves: 129/Sv * Swiss 		abnormal alveolar lamellar body morphology J:77480
abnormal angiogenesis J:77480
abnormal lung development J:77480
abnormal lung vasculature morphology J:77480
abnormal pulmonary alveolus epithelial cell morphology J:77480
abnormal surfactant secretion J:77480
atelectasis J:77480
cyanosis J:77480
decreased type II pneumocyte number J:77480
embryonic lethality during organogenesis, incomplete penetrance J:77480
neonatal lethality, complete penetrance J:77480, J:83549
prenatal lethality, incomplete penetrance J:83549
respiratory distress J:77480
respiratory failure J:77480
thick pulmonary interalveolar septum J:77480
Epas1tm1Rus/Epas1tm1Rus
either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6) 		congestive heart failure J:50964
decreased circulating noradrenaline level J:50964
decreased heart rate J:50964
embryonic lethality during organogenesis, incomplete penetrance J:50964
heart vascular congestion J:50964
lethality throughout fetal growth and development, complete penetrance J:50964
liver vascular congestion J:50964
visceral vascular congestion J:50964
Epas1tm1Yfk/Epas1tm1Yfk
involves: 129P2/OlaHsd * C57BL/6J 		abnormal eye electrophysiology J:82257
abnormal physiological neovascularization J:82257
abnormal retina inner nuclear layer morphology J:82257
Epas1tm1Yms/Epas1tm1Yms
Tg(Vil1-cre)20Syr/0
B6.Cg-Epas1tm1Yms Tg(Vil1-cre)20Syr 		decreased circulating iron level J:189504
decreased erythrocyte cell number J:189504
decreased hematocrit J:189504
decreased hemoglobin content J:189504
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory