Hfe Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hfe
homeostatic iron regulator
MGI:109191

10 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Unc/B2m^tm1Unc Hfe^tm2Nca/Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	increased liver iron level	J:62112
Cp^m1Cbea/Cp^m1Cbea Hfe^tm1Sly/Hfe^tm1Sly involves: C3H/DiSnA * C57BL/10ScSnA	hemochromatosis	J:122133
Gt(ROSA)26Sor^{tm1(Tfrc)Nca}/Gt(ROSA)26Sor⁺ Hfe^tm2Nca/Hfe^tm2Nca involves: 129S4/SvJae 129S6/SvEvTac * FVB/N	increased circulating iron level	J:133221
	increased liver iron level	J:133221
Heph^sla/Heph^sla Hfe^tm2Nca/Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	increased intestinal iron level	J:62112
	increased liver iron level	J:62112
Heph^sla/Y Hfe^tm2Nca/Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	increased intestinal iron level	J:62112
	increased liver iron level	J:62112
Hfe^tm1.1Nca/Hfe^tm1.1Nca Tfrc^tm1Nca/Tfrc⁺ Not Specified	increased liver iron level	J:62112
Hfe^tm1Gfn/? Hfem1^C57BL/6/Hfem1^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem1^DBA/2/Hfem1^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem2^C57BL/6/Hfem2^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem2^DBA/2/Hfem2^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem3^DBA/2/Hfem3^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem4^C57BL/6/Hfem4^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem4^DBA/2/Hfem4^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm2Nca/Hfe^tm2Nca Slc11a2^mk/Slc11a2^mk involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ	decreased liver iron level	J:62112
	postnatal lethality	J:62112
Hfe^tm2Nca/Hfe^tm2Nca Slc11a2^tm1Nca/Slc11a2^tm1Nca involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2^tm1Nca	decreased hematocrit	J:98088
	increased liver iron level	J:98088
	normal mortality/aging	J:98088
	postnatal growth retardation	J:98088
Hfe^tm2Nca/Hfe^tm2Nca Tfrc^tm1Nca/Tfrc⁺ involves: 129S6/SvEvTac	increased liver iron level	J:62112
Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺ involves: C57BL/6J	increased liver iron level	J:66704
Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺ involves: C57BL/6J	increased porphyrin level	J:66704

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24