Sema4d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
MGI:109244

18 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sema4d^{tm1b(EUCOMM)Wtsi}/Sema4d^{tm1b(EUCOMM)Wtsi} C57BL/6N-Sema4d^{tm1b(EUCOMM)Wtsi}/H	cataract	J:211773
	decreased bone mineral content	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased total body fat amount	J:211773
Sema4d^tm1Kik/Sema4d^tm1Kik B6.129P2-Sema4d^tm1Kik	normal renal/urinary system phenotype	J:221423
Sema4d^tm1Kik/Sema4d^tm1Kik involves: 129P2/OlaHsd	normal nervous system phenotype	J:119485
Sema4d^tm1Kik/Sema4d^tm1Kik involves: 129P2/OlaHsd * C57BL/6	abnormal B-1 B cell morphology	J:66033
	abnormal immunoglobulin level	J:66033
	normal behavior/neurological phenotype	J:66033
	normal cardiovascular system phenotype	J:66033
	decreased B cell proliferation	J:66033
	decreased B-1a cell number	J:66033
	decreased CD4-positive, alpha-beta T cell number	J:66033
	decreased spleen germinal center size	J:66033
	decreased T cell number	J:66033
	increased B cell number	J:66033
	normal nervous system phenotype	J:66033
	normal renal/urinary system phenotype	J:66033

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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