Ddit3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ddit3
DNA-damage inducible transcript 3
MGI:109247

20 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ddit3^{tm1.1(KOMP)Vlcg}/Ddit3^{tm1.1(KOMP)Vlcg} C57BL/6N-Ddit3^{tm1.1(KOMP)Vlcg}/Ucd	increased circulating aspartate transaminase level	J:211773
Ddit3^tm1Aki/Ddit3^tm1Aki involves: 129P2/OlaHsd	decreased neuron apoptosis	J:109623
Ddit3^tm1Aki/Ddit3^tm1Aki involves: 129P2/OlaHsd	increased brain weight	J:109623
Ddit3^tm1Aki/Ddit3^tm1Aki involves: 129P2/OlaHsd * C57BL/6	decreased apoptosis	J:76277
Ddit3^tm1Dron/Ddit3^tm1Dron B6.129-Ddit3^tm1Dron	abnormal macrophage activation involved in immune response	J:153833
Ddit3^tm1Dron/Ddit3^tm1Dron B6.129-Ddit3^tm1Dron	decreased macrophage apoptosis	J:153833
Ddit3^tm1Dron/Ddit3^tm1Dron either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	abnormal response to injury	J:52729
	decreased apoptosis	J:52729
	decreased fibroblast apoptosis	J:52729
Ddit3^tm1Dron/Ddit3^tm1Dron involves: 129S1/Sv * 129X1/SvJ	normal endocrine/exocrine gland phenotype	J:129974
Ddit3^tm1Dron/Ddit3^tm1Dron involves: 129S1/Sv * 129X1/SvJ * FVB/N	decreased susceptibility to Retroviridae infection	J:112354
Ddit3^tm2.1Dron/Ddit3^tm2.1Dron B6.129S(Cg)-Ddit3^tm2.1Dron/J	abnormal T cell morphology	J:214136
	decreased energy expenditure	J:214136
	decreased locomotor activity	J:214136
	hepatic steatosis	J:214136
	impaired glucose tolerance	J:214136
	increased cholesterol level	J:214136
	increased susceptibility to diet-induced obesity	J:214136
	increased total body fat amount	J:214136
	insulin resistance	J:214136
	white adipose tissue inflammation	J:214136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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