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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Psen2
presenilin 2
MGI:109284
17 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Psen2em1(IMPC)Ccpcz/Psen2em1(IMPC)Ccpcz
C57BL/6NCrl-Psen2em1(IMPC)Ccpcz/Ccpcz 		abnormal brain morphology J:211773
abnormal digit morphology J:211773
abnormal heart morphology J:211773
abnormal retina morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal thymus morphology J:211773
enlarged thymus J:211773
hydrocephaly J:211773
increased mean corpuscular hemoglobin J:211773
Psen2tm1Bdes/Psen2tm1Bdes
involves: 129P2/OlaHsd * C57BL/6J 		increased lung apoptosis J:58118
increased lung endothelial cell apoptosis J:58118
increased pulmonary alveolus wall thickness J:58118
normal limbs/digits/tail phenotype J:58118
lung hemorrhage J:58118
normal nervous system phenotype J:58118
pulmonary fibrosis J:58118
Psen2tm1Ber/Psen2tm1Ber
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		no abnormal phenotype detected J:58465
Psen2tm1Haa/Psen2tm1Haa
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:83860
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory