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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rad50
RAD50 double strand break repair protein
MGI:109292
21 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atmtm1Awb/Atm+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		abnormal seminiferous tubule morphology J:209141
abnormal testis size J:209141
normal hematopoietic system phenotype J:209141
normal nervous system phenotype J:209141
Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		anemia J:103922
decreased macrophage cell number J:103922
increased lymphoma incidence J:103922
premature death J:103922
Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle checkpoint function J:103922
anemia J:103922
normal cellular phenotype J:103922
chromosome breakage J:103922
increased lymphoma incidence J:103922
premature death J:103922
Atmtm1Awb/Atmtm1Awb
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		increased tumor latency J:209141
Chek2tm1Mak/Chek2+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal pro-B cell morphology J:103922
anemia J:103922
decreased double-negative T cell number J:103922
decreased macrophage cell number J:103922
premature death J:103922
Chek2tm1Mak/Chek2tm1Mak
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		normal hematopoietic system phenotype J:103922
increased lymphoma incidence J:103922
premature death J:103922
Mre11atm1Jpt/Mre11a+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal hematopoietic system morphology/development J:103922
anemia J:103922
increased lymphoma incidence J:103922
premature death J:103922
Mre11atm1Jpt/Mre11atm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle checkpoint function J:103922
chromosome breakage J:103922
normal hematopoietic system phenotype J:103922
increased cellular sensitivity to ionizing radiation J:103922
increased lymphoma incidence J:103922
premature death J:103922
Nbntm1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		normal hematopoietic system phenotype J:103922
Nbntm1Jpt/Nbntm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		normal hematopoietic system phenotype J:103922
Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * 129/Sv 		anemia J:129762
decreased apoptosis J:129762
normal mortality/aging J:129762
Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * 129/Sv 		anemia J:129762
decreased apoptosis J:129762
normal mortality/aging J:129762
Rad50tm2Jpt/Rad50tm2Jpt
Smc1atm1Mbk/Smc1atm1Mbk
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		abnormal hematopoietic system morphology/development J:103922
abnormal pro-B cell morphology J:103922
anemia J:103922
decreased double-negative T cell number J:103922
decreased macrophage cell number J:103922
premature death J:103922
Rad50tm2Jpt/Rad50tm2Jpt
Tg(BCL2)22Wehi/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi 		anemia J:103922
premature death J:103922
Rad50tm2Jpt/Rad50tm2Jpt
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal testis morphology J:78820
normal immune system phenotype J:78820
increased T cell derived lymphoma incidence J:78820
premature death J:78820
Rad50tm4.1Jpt/Rad50+
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129/Sv * C57BL/6 		abnormal seminiferous tubule morphology J:209141
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory