Mapkapk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298

25 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	decreased incidence of tumors by chemical induction	J:262876
Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Twist2^{tm1.1(cre)Dor}/Twist2⁺ involves: 129X1/SvJ * BALB/cJ * C57BL/6	decreased incidence of tumors by chemical induction	J:262876
Mapkapk2^tm1.1Yaff/Mapkapk2^tm1.1Yaff involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:203686
Mapkapk2^tm1.2Gkl/Mapkapk2^tm1.2Gkl involves: BALB/cJ * C57BL/6	decreased circulating tumor necrosis factor level	J:262876
	decreased incidence of tumors by chemical induction	J:262876
	decreased tumor necrosis factor secretion	J:262876
Mapkapk2^{tm1b(EUCOMM)Hmgu}/Mapkapk2^{tm1b(EUCOMM)Hmgu} C57BL/6N-Mapkapk2^{tm1b(EUCOMM)Hmgu}/H	abnormal bone structure	J:211773
	abnormal clavicle morphology	J:211773
	abnormal joint morphology	J:211773
	abnormal optic disk morphology	J:211773
	increased circulating glucose level	J:211773
	increased eosinophil cell number	J:211773
	increased large unstained cell number	J:211773
	increased leukocyte cell number	J:211773
Mapkapk2^tm1Dgen/Mapkapk2^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6	abnormal cytokine secretion	J:117668
Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl involves: 129P2/OlaHsd * C57BL/6J	abnormal cytokine level	J:59678
	abnormal macrophage derived foam cell morphology	J:142788
	abnormal response to cardiac infarction	J:101888
	decreased cardiomyocyte apoptosis	J:101888
	decreased circulating tumor necrosis factor level	J:59678
	decreased myocardial infarct size	J:101888
	decreased susceptibility to endotoxin shock	J:59678
	increased spleen germinal center size	J:59678
Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl involves: 129S * C57BL/6	decreased interferon-gamma secretion	J:76161
	decreased tumor necrosis factor secretion	J:76161
	impaired macrophage phagocytosis	J:76161
	increased interleukin-1 beta secretion	J:76161
	increased susceptibility to bacterial infection	J:76161
	increased susceptibility to bacterial infection induced morbidity/mortality	J:76161

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24