Mapkapk2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	decreased tumor growth/size	J:262876
Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Twist2^{tm1.1(cre)Dor}/Twist2⁺ involves: 129X1/SvJ * BALB/cJ * C57BL/6J	decreased tumor growth/size	J:262876
	decreased tumor incidence	J:262876
Apc^Min/Apc⁺ Mapkapk2^tm1.2Gkl/Mapkapk2^tm1.2Gkl involves: BALB/cJ * C57BL/6J	abnormal chemokine secretion	J:262876
	abnormal tumor vascularization	J:262876
	decreased interleukin-6 secretion	J:262876
	decreased tumor growth/size	J:262876
	decreased tumor incidence	J:262876
	normal hematopoietic system phenotype	J:262876
	increased intestinal adenoma incidence	J:262876
	increased tumor-free survival time	J:262876
	intestine polyps	J:262876
Kras^tm4Tyj/Kras⁺ Mapkapk2^tm1.1Yaff/Mapkapk2^tm1.1Yaff involves: 129S4/SvJae * C57BL/6	increased lung adenoma incidence	J:203686
Kras^tm4Tyj/Kras⁺ Mapkapk2^tm1.1Yaff/Mapkapk2^tm1.1Yaff Trp53^tm1Brn/Trp53^tm1Brn involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	increased lung adenoma incidence	J:203686
Ldlr^tm1Her/Ldlr^tm1Her Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	abnormal macrophage derived foam cell morphology	J:142788
	arteriosclerosis	J:142788
	decreased macrophage cell number	J:142788
	increased circulating cholesterol level	J:142788
Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Mapkapk3^tm1.1Lex/Mapkapk3^tm1.1Lex involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6	abnormal cytokine secretion	J:117668
	normal embryo phenotype	J:117668
	normal mortality/aging	J:117668
Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	decreased apoptosis	J:108572
	granulomatous inflammation	J:108572
	normal immune system phenotype	J:108572
	premature death	J:108572
	small intestinal inflammation	J:108572

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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