Fadd Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fadd
Fas associated via death domain
MGI:109324

50 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fadd^tm1.1Mpa/Fadd^tm1.1Mpa involves: BALB/cJ * C57BL/6 * SJL	embryonic lethality	J:167475
Fadd^{tm1e.1(KOMP)Wtsi}/Fadd⁺ C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd	abnormal uterus morphology	J:211773
	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd	abnormal embryo size	J:211773
	abnormal neural tube closure	J:211773
	preweaning lethality, complete penetrance	J:211773
Fadd^tm1Mak/Fadd^tm1Mak either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	abnormal myocardium layer morphology	J:46527
	decreased embryo size	J:46527
	decreased fibroblast apoptosis	J:46527
	embryonic growth retardation	J:46527
	embryonic lethality during organogenesis, complete penetrance	J:46527
	internal hemorrhage	J:46527
	thin myocardium	J:46527
	trabecula carnea hypoplasia	J:46527
Fadd^tm1Mpa/Fadd^tm1Mpa Mog^tm1(cre)Gkl/Mog⁺ involves: C57BL/6 * SJL	abnormal oligodendrocyte apoptosis	J:167475
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:167475
	normal immune system phenotype	J:167475
	normal nervous system phenotype	J:167475
Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0 B6.Cg-Fadd^tm1Mpa Tg(Vil1-cre)997Gum	abnormal cecum morphology	J:175865
	abnormal colon morphology	J:175865
	abnormal enterocyte physiology	J:175865
	abnormal enterocyte proliferation	J:175865
	abnormal intestinal mucosa morphology	J:175865
	cecum inflammation	J:175865
	colitis	J:175865
	crypts of Lieberkuhn abscesses	J:175865
	decreased body weight	J:175865
	decreased Paneth cell number	J:175865
	diarrhea	J:175865
	increased enterocyte apoptosis	J:175865
	intestinal ulcer	J:175865
	postnatal lethality, incomplete penetrance	J:175865
Fadd^tm1Wnt/Fadd^tm1Wnt involves: 129S4/SvJae	decreased sensitivity to induced cell death	J:63946
Fadd^tm1Wnt/Fadd^tm1Wnt involves: 129S4/SvJae	embryonic lethality, complete penetrance	J:46526
Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Cd4-cre)1Cwi/? involves: 129S4/SvJae * C57BL/6 * DBA/2	decreased activated T cell number	J:113207
	decreased sensitivity to induced cell death	J:113207
	decreased single-positive T cell number	J:113207
	normal immune system phenotype	J:113207
	increased B cell number	J:113207
Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Lck-cre)1Cwi/? involves: 129S4/SvJae	decreased activated T cell number	J:113207
	decreased sensitivity to induced cell death	J:113207
	decreased single-positive T cell number	J:113207
	normal immune system phenotype	J:113207
	increased B cell number	J:113207
Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Mx1-cre)1Cgn/? involves: 129S4/SvJae * C57BL/6 * CBA	abnormal bone marrow cell morphology/development	J:168722
	abnormal erythrocyte morphology	J:168722
	decreased bone marrow cell number	J:168722
	spleen hypoplasia	J:168722
	thymus hypoplasia	J:168722
Fadd^tm2.1Wnt/Fadd^tm2.1Wnt Tg(Cd4-cre)1Cwi/? B6.Cg-Tg(Cd4-cre)1Cwi Fadd^tm2.1Wnt	abnormal erythrocyte cell number	J:162312
	abnormal T cell proliferation	J:162312
	abnormal T cell subpopulation ratio	J:162312
	abnormal thymocyte apoptosis	J:162312
	enlarged lymph nodes	J:162312
	enlarged spleen	J:162312
	increased B cell number	J:162312
	increased susceptibility to parasitic infection	J:162312

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