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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irs2
insulin receptor substrate 2
MGI:109334
93 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irs2M1Btlr/Irs2M1Btlr
C57BL/6J-Irs2M1Btlr 		hyperglycemia J:267533
increased insulin secretion J:267533
Irs2tm1.1With/Irs2tm1.1With
B6.129S6-Irs2tm1.1With 		abnormal corpus luteum morphology J:122064
abnormal ovarian follicle morphology J:122064
abnormal ovarian folliculogenesis J:122064
absent mature ovarian follicles J:122064
decreased granulosa cell proliferation J:122064
decreased tertiary ovarian follicle number J:122064
increased atretic ovarian follicle number J:122064
polyovular ovarian follicle J:122064
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal retina progenitor cell morphology J:98107
decreased total retina thickness J:98107
retina outer nuclear layer degeneration J:98107
retina photoreceptor degeneration J:98107
short photoreceptor inner segment J:98107
short photoreceptor outer segment J:98107
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal circulating glucose level J:74303
abnormal circulating hormone level J:64791
abnormal circulating insulin level J:94000
abnormal energy homeostasis J:64791
abnormal glucose homeostasis J:64791, J:74303
abnormal lipid homeostasis J:96047
abnormal mating frequency J:64791
abnormal oogenesis J:64791
abnormal ovarian follicle morphology J:64791
abnormal pancreatic beta cell morphology J:96047
absent corpus luteum J:64791
absent estrous cycle J:64791
anovulation J:64791
decreased birth body size J:46134
decreased body weight J:46134, J:74303
decreased circulating estradiol level J:64791
decreased circulating luteinizing hormone level J:64791
decreased circulating progesterone level J:64791
decreased circulating prolactin level J:64791
decreased circulating testosterone level J:64791
decreased gonadotroph cell number J:64791
decreased oocyte number J:64791
decreased pancreatic beta cell mass J:46134, J:135659
decreased pancreatic beta cell number J:94000
decreased primary ovarian follicle number J:64791
decreased skeletal muscle glycogen level J:74303
failure of superovulation J:64791
female infertility J:64791
hyperglycemia J:46134, J:94000, J:96047, J:135659
impaired glucose tolerance J:46134, J:64791
impaired ovarian folliculogenesis J:64791
increased circulating insulin level J:46134, J:135659
increased circulating leptin level J:64791
increased total body fat amount J:64791
insulin resistance J:46134, J:135659
obese J:64791
polydipsia J:46134
polyphagia J:64791
polyuria J:46134
premature death J:46134, J:94000
reduced female fertility J:64791
reduced male fertility J:64791
small ovary J:64791
small pancreatic islets J:96047
small pituitary gland J:64791
small pituitary intermediate lobe J:74303
weight loss J:135659
Irs2tm1Mfw/Irs2tm1Mfw
Tg(Ins2-Irs2)13Mfw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal b-wave implicit time J:98107
abnormal cone electrophysiology J:98107
abnormal pancreatic beta cell morphology J:94000
abnormal rod electrophysiology J:98107
decreased a-wave amplitude J:98107
decreased b-wave amplitude J:98107
increased circulating insulin level J:94000
normal mortality/aging J:94000
Irs2tm1Tka/Irs2tm1Tka
involves: C57BL/6 * CBA 		abnormal cell differentiation J:68004
abnormal pancreatic beta cell morphology J:65485
abnormal vascular wound healing J:99746
decreased pancreatic beta cell mass J:65485
decreased vasodilation J:99746
normal growth/size/body region phenotype J:65485
hyperglycemia J:99746
impaired glucose tolerance J:65485
increased circulating cholesterol level J:99746
increased circulating free fatty acids level J:99746
increased circulating HDL cholesterol level J:99746
increased circulating insulin level J:65485
increased circulating triglyceride level J:99746
increased insulin secretion J:65485
increased systemic arterial systolic blood pressure J:99746
insulin resistance J:65485, J:99746
Irs2tm1With/Irs2tm1With
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6J 		decreased pancreatic beta cell number J:97406
impaired glucose tolerance J:97406
increased body length J:97406
increased body weight J:97406
increased circulating glucose level J:97406
increased circulating insulin level J:97406
increased circulating leptin level J:97406
polyphagia J:97406
Irs2tm1With/Irs2tm1With
Tg(Nes-cre)1Kln/?
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal prolactin level J:122064
prolonged diestrus J:122064
prolonged estrous cycle J:122064
Irs2tm1With/Irs2tm1With
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6J 		impaired glucose tolerance J:97406
increased body length J:97406
increased body weight J:97406
increased circulating glucose level J:97406
increased circulating insulin level J:97406
increased circulating leptin level J:97406
increased pancreatic beta cell mass J:97406
increased total body fat amount J:97406
polyphagia J:97406
Irs2tm1With/Irs2tm1With
Tg(Pomc1-cre)1Gsb/0
involves: 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:97406
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		normal homeostasis/metabolism phenotype J:137845
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal coat/hair pigmentation J:93415
abnormal pancreatic beta cell morphology J:93415
impaired glucose tolerance J:93415
increased body length J:93415
increased body weight J:93415
increased circulating glucose level J:93415
increased circulating insulin level J:93415
increased circulating leptin level J:93415
increased total body fat amount J:93415
insulin resistance J:93415
polydipsia J:93415
polyphagia J:93415
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-Irs2)13Mfw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal homeostasis/metabolism phenotype J:93415
increased body weight J:93415
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Nes-cre)1Kln/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal glucose homeostasis J:221293
decreased basal metabolism J:221293
decreased oxygen consumption J:221293
impaired glucose tolerance J:221293
increased circulating glucose level J:221293
increased circulating insulin level J:221293
increased circulating leptin level J:221293
increased fasting circulating glucose level J:221293
increased food intake J:221293
insulin resistance J:221293
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA 		normal homeostasis/metabolism phenotype J:137846
increased circulating insulin level J:137846
insulin resistance J:137846
Irs2tm2Tka/Irs2tm2Tka
Tg(Ins2-cre)25Mgn/0
involves: 129S4/SvJae * C57BL/6 		decreased pancreatic beta cell mass J:93416
decreased response to leptin J:93416
impaired glucose tolerance J:93416
increased body weight J:93416
increased circulating cholesterol level J:93416
increased circulating glucose level J:93416
increased circulating leptin level J:93416
increased circulating triglyceride level J:93416
increased epididymal fat pad weight J:93416
insulin resistance J:93416
obese J:93416
Tg(Ins2-Irs2)13Mfw/0
involves: C57BL/6 		abnormal pancreatic beta cell morphology J:94000
improved glucose tolerance J:94000
increased circulating insulin level J:94000
increased insulin secretion J:94000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory