Irs2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irs2
insulin receptor substrate 2
MGI:109334

45 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn1b^tm1Kin/Cdkn1b⁺ Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	enlarged pancreatic islets	J:96047
	increased circulating glucose level	J:96047
	increased circulating insulin level	J:96047
	increased pancreatic beta cell number	J:96047
Cdkn1b^tm1Kin/Cdkn1b^tm1Kin Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	enlarged pancreatic islets	J:96047
	increased circulating glucose level	J:96047
	increased circulating insulin level	J:96047
	increased pancreatic beta cell number	J:96047
Foxo1^tm1Rdp/Foxo1^tm1Rdp Irs1^tm1Mfw/Irs1^tm1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB	abnormal triglyceride level	J:137845
	decreased circulating cholesterol level	J:137845
	decreased circulating free fatty acids level	J:137845
	decreased circulating HDL cholesterol level	J:137845
	decreased circulating triglyceride level	J:137845
	normal homeostasis/metabolism phenotype	J:137845
Foxo1^tm1Whb/Foxo1⁺ Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal endocrine/exocrine gland phenotype	J:80826
	normal homeostasis/metabolism phenotype	J:80826
Gsk3b^tm1Jrw/Gsk3b⁺ Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal circulating glucose level	J:135659
	abnormal pancreatic islet cell apoptosis	J:135659
	normal growth/size/body region phenotype	J:135659
	increased circulating glucose level	J:135659
	increased circulating insulin level	J:135659
	increased pancreatic beta cell proliferation	J:135659
	insulin resistance	J:135659
Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Ins2-cre)23Herr/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal circulating glucose level	J:135659
	increased circulating insulin level	J:135659
Insr^tm1Dac/Insr⁺ Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal glucose homeostasis	J:80826
	absent pancreatic beta cells	J:80826
	postnatal lethality	J:80826
Irs1^tm1Jos/Irs1⁺ Irs2^tm2Mfw/Irs2^tm2Mfw Tg(Ins2-cre)25Mgn/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pancreatic beta cell morphology	J:93415
	decreased body weight	J:93415
	decreased circulating insulin level	J:93415
	hyperglycemia	J:93415
Irs1^tm1Mfw/Irs1⁺ Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	impaired glucose tolerance	J:156999
Irs1^tm1Mfw/Irs1^tm1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal triglyceride level	J:137845
	decreased body size	J:137845
	decreased circulating cholesterol level	J:137845
	decreased circulating free fatty acids level	J:137845
	decreased circulating HDL cholesterol level	J:137845
	decreased circulating triglyceride level	J:137845
	decreased liver glycogen level	J:137845
	hyperglycemia	J:137845
	impaired glucose tolerance	J:137845
	increased circulating glucose level	J:137845
	increased circulating insulin level	J:137845
	increased susceptibility to autoimmune diabetes	J:137845
	insulin resistance	J:137845
Irs1^tm1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	impaired glucose tolerance	J:156999
	increased circulating insulin level	J:156999
	insulin resistance	J:156999
Irs1^tm1Tka/Irs1^tm1Tka Irs2^tm1Tka/Irs2^tm1Tka involves: C57BL/6 * CBA	abnormal cell differentiation	J:68004
	decreased white adipose tissue amount	J:68004
Irs1^tm2.1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	impaired glucose tolerance	J:156999
	increased circulating insulin level	J:156999
Irs1^tm2Tka/Irs1^tm2Tka Irs2^tm2Tka/Irs2^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	increased susceptibility to autoimmune diabetes	J:137846
	insulin resistance	J:137846
Irs2^tm1Mfw/Irs2^tm1Mfw Ptpn1^tm1Bbk/Ptpn1^tm1Bbk involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pancreatic beta cell morphology	J:87249
	decreased body weight	J:87249
	hyperglycemia	J:87249
	impaired glucose tolerance	J:87249
	increased insulin sensitivity	J:87249
	pancreatic islet hyperplasia	J:87249
	premature death	J:87249
Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Pdx1)#Mmy/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina layer morphology	J:98107
	decreased total retina thickness	J:98107
	retina outer nuclear layer degeneration	J:98107
	retina photoreceptor degeneration	J:98107
Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:221293
	normal homeostasis/metabolism phenotype	J:221293
Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Tg(Nes-cre)1Kln/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal adipose tissue amount	J:221293
	abnormal glucose homeostasis	J:221293
	decreased basal metabolism	J:221293
	decreased oxygen consumption	J:221293
	hepatic steatosis	J:221293
	impaired glucose tolerance	J:221293
	increased body weight	J:221293
	increased brown fat cell lipid droplet size	J:221293
	increased circulating glucose level	J:221293
	increased circulating insulin level	J:221293
	increased circulating leptin level	J:221293
	increased fasting circulating glucose level	J:221293
	increased food intake	J:221293
	insulin resistance	J:221293

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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