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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Brca2
breast cancer 2, early onset
MGI:109337
95 phenotypes from 16 alleles in 26 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brca2tm1.1Brn/Brca2tm1.1Brn
involves: 129P2/OlaHsd * BALB/cJ * FVB/N 		abnormal embryo development J:73028
embryonic growth retardation J:73028
embryonic lethality, complete penetrance J:73028
Brca2tm1.1Sks/Brca2tm1.1Sks
involves: 129 * C57BL/6J * FVB/N 		normal reproductive system phenotype J:187434
Brca2tm1Arge/Brca2+
involves: 129S/SvEv * C57BL/6 		normal neoplasm J:40594
Brca2tm1Arge/Brca2tm1Arge
involves: 129S/SvEv * C57BL/6 		abnormal amnion morphology J:40594
abnormal embryo development J:40594
abnormal extraembryonic tissue morphology J:40594
abnormal proamniotic cavity morphology J:40594
abnormal visceral yolk sac morphology J:40594
decreased embryo size J:40594
embryonic lethality, complete penetrance J:40594
enlarged allantois J:40594
Brca2tm1Arge/Brca2tm2Arge
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:70564
Brca2tm1Arge/Brca2tm2Arge
Waptm1(cre)Arge/Wap+
involves: 129S/SvEv * C57BL/6 		increased mammary adenocarcinoma incidence J:70564
Brca2tm1Brd/Brca2+
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:39764
Brca2tm1Brd/Brca2tm1.1Sks
involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N 		normal reproductive system phenotype J:187434
Brca2tm1Brd/Brca2tm1Brd
involves: 129S7/SvEvBrd 		abnormal developmental patterning J:39764
abnormal embryonic tissue morphology J:39764
abnormal extraembryonic tissue morphology J:39764
prenatal lethality, complete penetrance J:39764
Brca2tm1Brn/Brca2tm1Brn
involves: 129P2/OlaHsd * FVB/N 		no abnormal phenotype detected J:73028
Brca2tm1Brn/Brca2tm1Brn
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd 		chromosome breakage J:197442
Brca2tm1Brn/Brca2tm1Brn
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		normal nervous system phenotype J:144617
Brca2tm1Brn/Brca2tm1Brn
Tg(Pbsn-cre)4Prb/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal prostate gland physiology J:161511
increased prostate intraepithelial neoplasia incidence J:161511
prostate gland hyperplasia J:161511
Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N 		exocrine pancreatic insufficiency J:166678
premature death J:166678
Brca2tm1Cam/Brca2tm1Cam
129S/SvEv-Brca2tm1Cam 		abnormal axial skeleton morphology J:46812
embryonic growth retardation J:46812
neonatal lethality, incomplete penetrance J:46812
postnatal lethality, incomplete penetrance J:46812
prenatal lethality, incomplete penetrance J:46812
Brca2tm1Cam/Brca2tm1Cam
involves: 129S/SvEv 		abnormal mitosis J:93261
Brca2tm1Cam/Brca2tm1Cam
involves: 129S/SvEv * MF1 		abnormal axial skeleton morphology J:46812
absent germ cells J:46812
embryonic growth retardation J:46812
embryonic lethality during organogenesis, incomplete penetrance J:46812
female infertility J:46812
increased T cell derived lymphoma incidence J:46812
increased thymus weight J:46812
male infertility J:46812
neonatal lethality, incomplete penetrance J:46812
perinatal lethality, incomplete penetrance J:46812
postnatal lethality, incomplete penetrance J:46812
premature death J:46812
Brca2tm1Cbl/Brca2tm1Cbl
either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2) 		abnormal double-strand DNA break repair J:44386
abnormal epidermal layer morphology J:44386
abnormal epidermis stratum basale morphology J:44386
abnormal epidermis stratum spinosum morphology J:44386
abnormal rib morphology J:44386
abnormal skin morphology J:44386
abnormal sternum morphology J:44386
absent epidermis stratum corneum J:44386
absent ovarian follicles J:44386
azoospermia J:44386
decreased birth weight J:44386
decreased body weight J:44386
decreased fetal weight J:44386
decreased fibroblast proliferation J:44386
fetal growth retardation J:44386
increased T cell derived lymphoma incidence J:44386
kinked tail J:44386
male infertility J:44386
ovary degeneration J:44386
postnatal lethality, incomplete penetrance J:44386
premature death J:44386
small ovary J:44386
small testis J:44386
Brca2tm1Hst/Brca2tm1Hst
involves: 129S7/SvEvBrd * C57BL/6 		decreased tumor latency J:82434
increased carcinoma incidence J:82434
increased lymphoma incidence J:82434
premature death J:82434
sepsis J:82434
Brca2tm1Hst/Brca2tm2Hst
involves: 129S7/SvEvBrd * C57BL/6 		chromosomal instability J:82434
early cellular replicative senescence J:82434
Brca2tm1Kamc/Brca2tm1Kamc
involves: 129P2/OlaHsd 		small testis J:268570
Brca2tm1Kamc/Brca2tm1Kamc
involves: 129P2/OlaHsd * BALB/c 		abnormal chromosome morphology J:144998
abnormal DNA repair J:144998
abnormal hematopoietic system morphology/development J:144998
decreased body weight J:144998
decreased bone marrow cell number J:144998
decreased common myeloid progenitor cell number J:144998
impaired hematopoiesis J:144998
increased mortality induced by ionizing radiation J:144998
increased sensitivity to induced cell death J:144998
spleen hypoplasia J:144998
Brca2tm1Kamc/Brca2tm1Kamc
involves: 129P2/OlaHsd * C57BL/6N 		abnormal branching of the mammary ductal tree J:75026
decreased survivor rate J:75026, J:109193
increased tumor incidence J:75026
lethality throughout fetal growth and development, incomplete penetrance J:75026
normal neoplasm J:109193
normal reproductive system phenotype J:75026
Brca2tm1Mak/Brca2tm2Mak
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal chromosome morphology J:79697
aneuploidy J:79697
normal cellular phenotype J:79697
normal immune system phenotype J:79697
increased T cell apoptosis J:79697
normal neoplasm J:79697
Brca2tm1Mbn/Brca2+
B6.Cg-Brca2tm1Mbn ApcMin 		adrenal gland hyperplasia J:67445
normal growth/size/body region phenotype J:67445
increased mammary gland tumor incidence J:67445
normal reproductive system phenotype J:67445
Brca2tm1Mbn/Brca2+
involves: 129P2/OlaHsd * 129S/SvEv 		abnormal motor capabilities/coordination/movement J:74077
Brca2tm1Mbn/Brca2tm1Mbn
C.129P2-Brca2tm1Mbn 		embryonic growth retardation J:74077
embryonic lethality during organogenesis, complete penetrance J:74077
open neural tube J:74077
Brca2tm1Mbn/Brca2tm1Mbn
involves: 129P2/OlaHsd * 129S/SvEv 		embryonic lethality between somite formation and embryo turning, complete penetrance J:74077
Brca2tm1Mhun/Brca2+
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal cell physiology J:89083
decreased incidence of tumors by chemical induction J:89083
decreased tumor incidence J:89083
increased apoptosis J:89083
Brca2tm1Mhun/Brca2tm1Mhun
involves: 129S7/SvEvBrd * C57BL/6J 		embryonic lethality during organogenesis, complete penetrance J:89083
Brca2tm2.1Sks/Brca2tm1Brd
B6.Cg-Brca2tm1Brd Brca2tm2.1Sks 		abnormal branching of the mammary ductal tree J:323630
normal behavior/neurological phenotype J:323630
decreased birth body size J:323630
decreased birth weight J:323630
decreased body size J:323630
decreased body weight J:323630
decreased embryo size J:323630
decreased mammary duct terminal end bud number J:323630
normal embryo phenotype J:323630
normal growth/size/body region phenotype J:323630
increased mortality induced by ionizing radiation J:323630
normal neoplasm J:323630
premature death J:323630
prenatal lethality, incomplete penetrance J:323630
normal reproductive system phenotype J:323630
Brca2tm2.1Sks/Brca2tm2.1Sks
Not Specified 		decreased embryo size J:323630
normal embryo phenotype J:323630
normal homeostasis/metabolism phenotype J:323630
normal mortality/aging J:323630
normal neoplasm J:323630
prenatal lethality, incomplete penetrance J:323630
normal reproductive system phenotype J:323630
Brca2tm2Arge/Brca2tm2Arge
Waptm1(cre)Arge/Waptm1(cre)Arge
involves: 129S1/Sv * C57BL/6 		increased mammary adenocarcinoma incidence J:70564
Brca2tm2Hst/Brca2tm2Hst
involves: 129S7/SvEvBrd * C57BL/6 		embryonic lethality, complete penetrance J:82434
Brca2tm2Mak/Brca2tm2Mak
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:79697
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory