About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pitx2
paired-like homeodomain transcription factor 2
MGI:109340
63 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Irf6tm1Bcsl/Irf6tm1Bcsl
Pitx2tm4(cre)Jfm/Pitx2+
involves: 129 		abnormal ameloblast morphology J:275989
abnormal enamel development J:275989
abnormal enamel mineralization J:275989
abnormal enamel morphology J:275989
abnormal enamel rod pattern J:275989
abnormal Hertwig epithelial root sheath morphology J:275989
abnormal incisor color J:275989
abnormal incisor morphology J:275989
abnormal molar crown morphology J:275989
abnormal molar cusp morphology J:275989
abnormal molar morphology J:275989
abnormal molar root morphology J:275989
abnormal tooth morphology J:275989
decreased molar number J:275989
reduced enamel thickness J:275989
supernumerary teeth J:275989
taurodontia J:275989
Lmx1btm1Rjo/Lmx1btm4.1Rjo
Pitx2tm4(cre)Jfm/Pitx2+
involves: 129S7/SvEvBrd 		abnormal cornea endothelium morphology J:161793
abnormal cornea morphology J:161793
abnormal intraocular muscle morphology J:161793
abnormal iridocorneal angle J:161793
abnormal lens epithelium morphology J:161793
abnormal lens morphology J:161793
absent ciliary body J:161793
absent trabecular meshwork J:161793
cornea opacity J:161793
iris hypoplasia J:161793
irregularly shaped pupil J:161793
microphthalmia J:161793
small lens J:161793
Pitx1tm1Jdr/Pitx1+
Pitx2tm1Sac/Pitx2tm1Sac
involves: 129S1/Sv * 129X1/SvJ 		small Rathke's pouch J:73774
Pitx1tm1Jdr/Pitx1tm1Jdr
Pitx2tm1Sac/Pitx2+
involves: 129S1/Sv * 129X1/SvJ 		small Rathke's pouch J:73774
Pitx1tm1Jdr/Pitx1tm1Jdr
Pitx2tm1Sac/Pitx2tm1Sac
involves: 129S1/Sv * 129X1/SvJ 		abnormal fibula morphology J:80020
abnormal hindlimb morphology J:80020
abnormal Rathke's pouch development J:73774
absent femur J:80020
absent tibia J:80020
oligodactyly J:80020
small limb buds J:80020
Pitx1tm1Jdr/Pitx1tm1Jdr
Pitx2tm1Sac/Pitx2tm2Sac
involves: 129S1/Sv * 129X1/SvJ 		small limb buds J:80020
Pitx1tm1Jdr/Pitx1tm1Jdr
Pitx2tm2Sac/Pitx2+
involves: 129S1/Sv * 129X1/SvJ 		absent femur J:80020
small hindlimb buds J:80020
Pitx2tm1.1Sac/Pitx2tm2Sac
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Gt(ROSA)26Sortm1Sor/?
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA 		abnormal eye development J:104125
abnormal eye muscle development J:104125
abnormal eye pigmentation J:104125
abnormal optic stalk morphology J:104125
abnormal retina pigmentation J:104125
absent optic nerve J:104125
absent sclera J:104125
anophthalmia J:104125
decreased cornea stroma thickness J:104125
Pitx2tm2Sac/Pitx2+
Tbx1tm1Bem/Tbx1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		abnormal atrioventricular valve morphology J:107397
abnormal coronary vessel morphology J:107397
abnormal fetal atrioventricular canal morphology J:107397
abnormal heart and great vessel attachment J:107397
abnormal heart morphology J:107397
abnormal heart shape J:107397
abnormal heart ventricle morphology J:107397
anomalous pulmonary venous connection J:107397
atrial septal defect J:107397
common atrioventricular valve J:107397
cyanosis J:107397
double outlet right ventricle J:107397
neonatal lethality, complete penetrance J:107397
supravalvar pulmonary trunk stenosis J:107397
ventricular septal defect J:107397
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory