Atf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atf2
activating transcription factor 2
MGI:109349

57 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atf2^{tm1b(EUCOMM)Hmgu}/Atf2⁺ C57BL/6N-Atf2^{tm1b(EUCOMM)Hmgu}/Ccpcz	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal urinary bladder morphology	J:211773
	decreased body weight	J:211773
	decreased circulating chloride level	J:211773
	decreased mean platelet volume	J:211773
	enlarged heart	J:211773
	increased fasting circulating glucose level	J:211773
	increased lung elastance	J:211773
	small testis	J:211773
Atf2^tm1Glm/Atf2⁺ involves: 129S2/SvPas	postnatal lethality	J:30611
Atf2^tm1Glm/Atf2^tm1Glm C.Cg-Atf2^tm1Glm	abnormal cytokine secretion	J:67176
	decreased body weight	J:67176
	normal immune system phenotype	J:67176
	increased susceptibility to endotoxin shock	J:67176
	increased susceptibility to Herpesvirales infection	J:67176
	increased susceptibility to Picornaviridae infection	J:67176
Atf2^tm1Glm/Atf2^tm1Glm involves: 129S2/SvPas	abnormal chondrocyte morphology	J:30611
	abnormal long bone epiphyseal plate morphology	J:30611
	abnormal utricular macula morphology	J:30611
	abnormal vestibular ganglion morphology	J:30611
	abnormal vestibular saccular macula morphology	J:30611
	ataxia	J:30611
	chondrodystrophy	J:30611
	decreased body weight	J:30611
	decreased brain size	J:30611
	decreased long bone epiphyseal plate size	J:30611
	decreased otolith number	J:30611
	decreased Purkinje cell number	J:30611
	decreased vestibular hair cell number	J:30611
	decreased vestibular hair cell stereocilia number	J:30611
	disorganized long bone epiphyseal plate	J:30611
	ectopic Purkinje cell	J:30611
	enlarged brain ventricles	J:30611
	eye inflammation	J:30611
	head shaking	J:30611
	head tossing	J:30611
	hyperactivity	J:30611
	impaired hearing	J:30611
	impaired limb coordination	J:30611
	increased susceptibility to bacterial infection	J:30611
	postnatal lethality, incomplete penetrance	J:30611
	proportional dwarf	J:30611
	rhizomelic limb	J:30611
	tremors	J:30611
Atf2^tm1Glm/Atf2^tm1Sis involves: 129S2/SvPas * C57BL/6 * CBA	neonatal lethality, complete penetrance	J:55657
	respiratory failure	J:55657
Atf2^tm1Nicj/Atf2^tm1Nicj B6.129P2-Atf2^tm1Nicj	cyanosis	J:123909
Atf2^tm1Nicj/Atf2^tm1Nicj B6.129P2-Atf2^tm1Nicj	neonatal lethality, complete penetrance	J:123909
Atf2^tm1Sis/Atf2^tm1Sis either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)	abnormal lung morphology	J:55657
	abnormal placenta labyrinth morphology	J:55657
	abnormal placenta vasculature	J:55657
	cyanosis	J:55657
	hypoxia	J:55657
	neonatal lethality, complete penetrance	J:55657
	respiratory failure	J:55657
Atf2^tm2Nicj/Atf2^tm2Nicj B6.129P2-Atf2^tm2Nicj	cyanosis	J:123909
Atf2^tm2Nicj/Atf2^tm2Nicj B6.129P2-Atf2^tm2Nicj	neonatal lethality, complete penetrance	J:123909
Atf2^tm3Nicj/Atf2^tm3Nicj involves: C57BL/6 * FVB/N	no abnormal phenotype detected	J:131564
Atf2^tm3Nicj/Atf2^tm3Nicj Tg(KRT14-cre)1Efu/? involves: C57BL/6 * FVB/N	epidermal hyperplasia	J:131564
	increased skin papilloma incidence	J:131564
	thick epidermis	J:131564

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