Stx1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stx1a
syntaxin 1A (brain)
MGI:109355

33 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stx1a^tm1.1Sud/Stx1a^tm1.1Sud involves: C57BL/6	no abnormal phenotype detected	J:144771
Stx1a^{tm1b(EUCOMM)Hmgu}/Stx1a^{tm1b(EUCOMM)Hmgu} C57BL/6N-Stx1a^{tm1b(EUCOMM)Hmgu}/Bay	decreased grip strength	J:211773
	decreased total retina thickness	J:211773
Stx1a^tm1Gwz/Stx1a^tm1Gwz Not Specified	normal behavior/neurological phenotype	J:141037
	decreased body weight	J:141037
	decreased fetal size	J:141037
	embryonic growth retardation	J:141037
	lethality at weaning, incomplete penetrance	J:141037
	lethality throughout fetal growth and development, incomplete penetrance	J:141037
Stx1a^tm1Migar/Stx1a⁺ involves: C57BL/6N	abnormal depression-related behavior	J:204968
	abnormal neuron physiology	J:204968
	abnormal spatial working memory	J:204968
	abnormal synaptic vesicle number	J:204968
	abnormal synaptic vesicle recycling	J:204968
	decreased anxiety-related response	J:204968
	decreased synaptic depression	J:204968
	enhanced paired-pulse facilitation	J:204968
	impaired contextual conditioning behavior	J:204968
	impaired synaptic plasticity	J:204968
	increased locomotor activity	J:204968
	increased post-tetanic potentiation	J:204968
	normal nervous system phenotype	J:204968
Stx1a^tm1Tfuj/Stx1a⁺ B6.Cg-Stx1a^tm1Tfuj	abnormal latent inhibition of conditioning behavior	J:171786
	abnormal response to novel object	J:171786
	abnormal social investigation	J:171786
	increased startle reflex	J:171786
Stx1a^tm1Tfuj/Stx1a^tm1Tfuj B6.Cg-Stx1a^tm1Tfuj	abnormal hypothalamus secretion	J:171786
	abnormal latent inhibition of conditioning behavior	J:171786
	abnormal nervous system physiology	J:171786
	abnormal response to novel object	J:171786
	abnormal social investigation	J:171786
	increased serotonin level	J:171786
	increased startle reflex	J:171786
Stx1a^tm1Tfuj/Stx1a^tm1Tfuj involves: C57BL/6J	abnormal cued conditioning behavior	J:109042
	abnormal excitatory postsynaptic potential	J:109042
	normal mortality/aging	J:109042
	reduced long-term potentiation	J:109042
Stx1a^tm2.1Sud/Stx1a^tm2.1Sud involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal mortality/aging	J:138035

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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