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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atf3
activating transcription factor 3
MGI:109384
33 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atf3tm1.1Hai/Atf3tm1.1Hai
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * FVB/N 		decreased metastatic potential J:201626
Atf3tm1.2Kitab/Atf3tm1.2Kitab
Tg(Pdx1-cre)89.1Dam/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA 		abnormal hypothalamus physiology J:231262
abnormal sympathetic nervous system physiology J:231262
abnormal white adipose tissue physiology J:231262
abnormal white fat cell morphology J:231262
decreased abdominal adipose tissue amount J:231262
decreased body weight J:231262
decreased circulating glucose level J:231262
decreased epididymal fat pad weight J:231262
decreased food intake J:231262
decreased inguinal fat pad weight J:231262
decreased subcutaneous adipose tissue amount J:231262
decreased white adipose tissue amount J:231262
normal endocrine/exocrine gland phenotype J:231262
normal homeostasis/metabolism phenotype J:231262
improved glucose tolerance J:231262
increased basal metabolism J:231262
increased body temperature J:231262
increased carbon dioxide production J:231262
increased energy expenditure J:231262
increased insulin sensitivity J:231262
increased oxygen consumption J:231262
increased respiratory quotient J:231262
Atf3tm1Dron/Atf3tm1Dron
B6.129X1-Atf3tm1Hai 		abnormal pancreatic islet morphology J:91595
Atf3tm1Dron/Atf3tm1Dron
involves: 129X1/SvJ * C57BL/6 		abnormal T-helper 2 physiology J:140112
decreased IgG2a level J:140112
decreased metastatic potential J:201626
increased interleukin-4 secretion J:140112
increased interleukin-5 secretion J:140112
increased interleukin-13 secretion J:140112
lung inflammation J:140112
normal neoplasm J:201626
Atf3tm2b(EUCOMM)Wtsi/Atf3tm2b(EUCOMM)Wtsi
C57BL/6N-Atf3tm2b(EUCOMM)Wtsi/H 		abnormal retina morphology J:211773
decreased locomotor activity J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory