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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Esr2
estrogen receptor 2 (beta)
MGI:109392
144 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Esr2tm1.1Gust/Esr2tm1.1Gust
B6J.129X1(Cg)-Esr2tm1.1Gust 		abnormal tertiary ovarian follicle morphology J:220968
absent corpus luteum J:220968
absent mature ovarian follicles J:220968
anovulation J:220968
female infertility J:220968
increased atretic ovarian follicle number J:220968
increased secondary ovarian follicle number J:220968
normal reproductive system phenotype J:220968
Esr2tm1.1Ksk/Esr2tm1.1Ksk
involves: C57BL/6 		decreased ovulation rate J:198474
failure of superovulation J:198474
reduced female fertility J:198474
Esr2tm1.1Pcn/Esr2tm1.1Pcn
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas 		delayed wound healing J:165719
Esr2tm1.1Pcn/Esr2tm1.1Pcn
Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL 		delayed wound healing J:165719
Esr2tm1.2Pcn/Esr2tm1.2Pcn
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal estrous cycle J:132171
normal cardiovascular system phenotype J:132171
decreased corpora lutea number J:132171
normal digestive/alimentary phenotype J:132171
failure of superovulation J:132171
female infertility J:132171
normal immune system phenotype J:132171
increased atretic ovarian follicle number J:132171
male infertility J:132171
normal nervous system phenotype J:132171
normal renal/urinary system phenotype J:132171
normal reproductive system phenotype J:132171
normal respiratory system phenotype J:132171
Esr2tm1Dgen/Esr2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:82809
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas 		abnormal germ cell morphology J:105626
normal reproductive system phenotype J:105626
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas 		abnormal bone ossification J:123373
abnormal germ cell morphology J:105626
abnormal response/metabolism to endogenous compounds J:64426
decreased corpora lutea number J:64426
decreased volumetric bone mineral density J:123373
delayed wound healing J:165719
normal homeostasis/metabolism phenotype J:123373
increased bone strength J:123373
increased neutrophil cell number J:165719
increased total body fat amount J:123373
reduced female fertility J:64426
normal renal/urinary system phenotype J:64426
normal reproductive system phenotype J:64426, J:105626
short ulna J:123373
normal skeleton phenotype J:123373
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 		abnormal synaptic plasticity J:72240
decreased chemical nociceptive threshold J:130786
decreased locomotor activity J:72240
decreased vertical activity J:72240
increased anxiety-related response J:72240
increased thigmotaxis J:72240
Esr2tm1Unc/Esr2tm1Unc
B6.129P2-Esr2tm1Unc 		abnormal nociception after inflammation J:151022
decreased dopamine level J:101943
decreased exploration in new environment J:101943
decreased serotonin level J:101943
hyporesponsive to tactile stimuli J:151022
increased anxiety-related response J:101943
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd 		abnormal auditory brainstem response J:135833
abnormal behavior J:151012
abnormal enterocyte morphology J:107308
abnormal enterocyte physiology J:107308
abnormal enterocyte proliferation J:107308
abnormal excitatory postsynaptic potential J:115451
abnormal intercalated disk morphology J:93438
abnormal large intestine crypts of Lieberkuhn morphology J:107308
abnormal long bone epiphyseal plate morphology J:111108
abnormal mammary gland epithelium morphology J:125583
abnormal mammary gland growth during lactation J:125583
abnormal mammary gland growth during pregnancy J:125583
abnormal muscle contractility J:95398
abnormal myocardial fiber morphology J:93438
abnormal pulmonary alveolus morphology J:89974
abnormal response to cardiac infarction J:108991
abnormal response/metabolism to endogenous compounds J:64165
abnormal surfactant physiology J:89974
abnormal urinary bladder morphology J:122274
abnormal urinary bladder physiology J:122274
abnormal urinary bladder urothelium morphology J:122274
ascites J:108991
cardiac hypertrophy J:93438
colitis J:107308
decreased circulating glucose level J:151012
decreased enterocyte apoptosis J:107308
decreased insulin secretion J:151012
dilated heart ventricle J:93438
enlarged heart J:93438
enlarged pancreatic islets J:151012
impaired contextual conditioning behavior J:115451
impaired cued conditioning behavior J:115451
increased body length J:111108
increased body weight J:108991
increased circulating glucose level J:151012
increased heart weight J:108991
increased insulin sensitivity J:151012
increased myocardial fiber size J:93438
increased susceptibility to induced morbidity/mortality J:108991
increased urine glycosaminoglycan level J:122274
increased vasodilation J:64165
long femur J:111108
mammary gland alveolar hyperplasia J:125583
reduced long-term potentiation J:115451
urinary bladder inflammation J:122274
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 		abnormal response of heart to induced stress J:101968
decreased physiological sensitivity to xenobiotic J:101968
increased circulating luteinizing hormone level J:118736
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal astrocyte morphology J:67862
abnormal B cell number J:82423
abnormal bone marrow cell number J:82423
abnormal bone mineralization J:91765
abnormal cochlear IHC afferent innervation pattern J:108892
abnormal cumulus oophorus morphology J:51663
abnormal hair cycle catagen phase J:107589
abnormal leukopoiesis J:83617
abnormal lung morphology J:83617
abnormal lymphopoiesis J:83617
abnormal muscle electrophysiology J:73898
abnormal neocortex morphology J:67862
abnormal response/metabolism to endogenous compounds J:82423, J:110416
abnormal sexual interaction J:66582
abnormal somatosensory cortex morphology J:67862
abnormal spatial learning J:75472
abnormal substantia nigra morphology J:67862
abnormal superovulation J:51663
abnormal urinary bladder urothelium morphology J:51663
abnormal vascular smooth muscle morphology J:73898
abnormal vascular smooth muscle physiology J:73898
accelerated hair follicle regression J:107589
anemia J:83617
astrocytosis J:67862
normal behavior/neurological phenotype J:65785
decreased brain size J:67862
decreased corpora lutea number J:51663
decreased litter size J:51663
decreased mounting behavior J:66582
decreased neuron number J:67862
decreased superovulation rate J:51663
enlarged liver J:83617
enlarged lymph nodes J:83617
enlarged spleen J:83617
failure of superovulation J:51663
impaired ovarian folliculogenesis J:51663
increased aggression towards male mice J:66582
increased atretic ovarian follicle number J:51663
increased bone marrow cell number J:83617
increased chronic myelocytic leukemia incidence J:83617
increased circulating insulin-like growth factor I level J:110416
increased compact bone area J:91765
increased erythrocyte cell number J:83617
increased granulocyte number J:83617
increased keratinocyte apoptosis J:107589
increased leukocyte cell number J:83617
increased megakaryocyte cell number J:83617
increased monocyte cell number J:83617
increased neutrophil cell number J:83617
increased osteoblast cell number J:91765
increased pre-B cell number J:83617
increased pro-B cell number J:83617
increased systemic arterial blood pressure J:73898
increased vasoconstriction J:73898
myelofibrosis J:83617
neuron degeneration J:67862
prostate gland epithelial hyperplasia J:51663
reduced female fertility J:51663
normal reproductive system phenotype J:51663
normal skeleton phenotype J:62222
spleen hyperplasia J:83617
spleen hypoplasia J:110416
thin epidermis J:107589
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory