About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Esr2
estrogen receptor 2 (beta)
MGI:109392
144 phenotypes from 7 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Esr2tm1.1Gust/Esr2tm1.1Gust
B6J.129X1(Cg)-Esr2tm1.1Gust 		abnormal tertiary ovarian follicle morphology J:220968
absent corpus luteum J:220968
absent mature ovarian follicles J:220968
anovulation J:220968
female infertility J:220968
increased atretic ovarian follicle number J:220968
increased secondary ovarian follicle number J:220968
normal reproductive system phenotype J:220968
Esr2tm1.1Ksk/Esr2tm1.1Ksk
involves: C57BL/6 		decreased ovulation rate J:198474
failure of superovulation J:198474
reduced female fertility J:198474
Esr2tm1.1Pcn/Esr2tm1.1Pcn
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas 		delayed wound healing J:165719
Esr2tm1.1Pcn/Esr2tm1.1Pcn
Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL 		delayed wound healing J:165719
Esr2tm1.2Pcn/Esr2tm1.2Pcn
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal estrous cycle J:132171
normal cardiovascular system phenotype J:132171
decreased corpora lutea number J:132171
normal digestive/alimentary phenotype J:132171
failure of superovulation J:132171
female infertility J:132171
normal immune system phenotype J:132171
increased atretic ovarian follicle number J:132171
male infertility J:132171
normal nervous system phenotype J:132171
normal renal/urinary system phenotype J:132171
normal reproductive system phenotype J:132171
normal respiratory system phenotype J:132171
Esr2tm1Dgen/Esr2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:82809
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas 		abnormal germ cell morphology J:105626
normal reproductive system phenotype J:105626
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas 		abnormal bone ossification J:123373
abnormal germ cell morphology J:105626
abnormal response/metabolism to endogenous compounds J:64426
decreased corpora lutea number J:64426
decreased volumetric bone mineral density J:123373
delayed wound healing J:165719
normal homeostasis/metabolism phenotype J:123373
increased bone strength J:123373
increased neutrophil cell number J:165719
increased total body fat amount J:123373
reduced female fertility J:64426
normal renal/urinary system phenotype J:64426
normal reproductive system phenotype J:64426, J:105626
short ulna J:123373
normal skeleton phenotype J:123373
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 		abnormal synaptic plasticity J:72240
decreased chemical nociceptive threshold J:130786
decreased locomotor activity J:72240
decreased vertical activity J:72240
increased anxiety-related response J:72240
increased thigmotaxis J:72240
Esr2tm1Unc/Esr2tm1Unc
B6.129P2-Esr2tm1Unc 		abnormal nociception after inflammation J:151022
decreased dopamine level J:101943
decreased exploration in new environment J:101943
decreased serotonin level J:101943
hyporesponsive to tactile stimuli J:151022
increased anxiety-related response J:101943
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd 		abnormal auditory brainstem response J:135833
abnormal behavior J:151012
abnormal enterocyte morphology J:107308
abnormal enterocyte physiology J:107308
abnormal enterocyte proliferation J:107308
abnormal excitatory postsynaptic potential J:115451
abnormal intercalated disk morphology J:93438
abnormal large intestine crypts of Lieberkuhn morphology J:107308
abnormal long bone epiphyseal plate morphology J:111108
abnormal mammary gland epithelium morphology J:125583
abnormal mammary gland growth during lactation J:125583
abnormal mammary gland growth during pregnancy J:125583
abnormal muscle contractility J:95398
abnormal myocardial fiber morphology J:93438
abnormal pulmonary alveolus morphology J:89974
abnormal response to cardiac infarction J:108991
abnormal response/metabolism to endogenous compounds J:64165
abnormal surfactant physiology J:89974
abnormal urinary bladder morphology J:122274
abnormal urinary bladder physiology J:122274
abnormal urinary bladder urothelium morphology J:122274
ascites J:108991
cardiac hypertrophy J:93438
colitis J:107308
decreased circulating glucose level J:151012
decreased enterocyte apoptosis J:107308
decreased insulin secretion J:151012
dilated heart ventricle J:93438
enlarged heart J:93438
enlarged pancreatic islets J:151012
impaired contextual conditioning behavior J:115451
impaired cued conditioning behavior J:115451
increased body length J:111108
increased body weight J:108991
increased circulating glucose level J:151012
increased heart weight J:108991
increased insulin sensitivity J:151012
increased myocardial fiber size J:93438
increased susceptibility to induced morbidity/mortality J:108991
increased urine glycosaminoglycan level J:122274
increased vasodilation J:64165
long femur J:111108
mammary gland alveolar hyperplasia J:125583
reduced long-term potentiation J:115451
urinary bladder inflammation J:122274
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 		abnormal response of heart to induced stress J:101968
decreased physiological sensitivity to xenobiotic J:101968
increased circulating luteinizing hormone level J:118736
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal astrocyte morphology J:67862
abnormal B cell number J:82423
abnormal bone marrow cell number J:82423
abnormal bone mineralization J:91765
abnormal cochlear IHC afferent innervation pattern J:108892
abnormal cumulus oophorus morphology J:51663
abnormal hair cycle catagen phase J:107589
abnormal leukopoiesis J:83617
abnormal lung morphology J:83617
abnormal lymphopoiesis J:83617
abnormal muscle electrophysiology J:73898
abnormal neocortex morphology J:67862
abnormal response/metabolism to endogenous compounds J:82423, J:110416
abnormal sexual interaction J:66582
abnormal somatosensory cortex morphology J:67862
abnormal spatial learning J:75472
abnormal substantia nigra morphology J:67862
abnormal superovulation J:51663
abnormal urinary bladder urothelium morphology J:51663
abnormal vascular smooth muscle morphology J:73898
abnormal vascular smooth muscle physiology J:73898
accelerated hair follicle regression J:107589
anemia J:83617
astrocytosis J:67862
normal behavior/neurological phenotype J:65785
decreased brain size J:67862
decreased corpora lutea number J:51663
decreased litter size J:51663
decreased mounting behavior J:66582
decreased neuron number J:67862
decreased superovulation rate J:51663
enlarged liver J:83617
enlarged lymph nodes J:83617
enlarged spleen J:83617
failure of superovulation J:51663
impaired ovarian folliculogenesis J:51663
increased aggression towards male mice J:66582
increased atretic ovarian follicle number J:51663
increased bone marrow cell number J:83617
increased chronic myelocytic leukemia incidence J:83617
increased circulating insulin-like growth factor I level J:110416
increased compact bone area J:91765
increased erythrocyte cell number J:83617
increased granulocyte number J:83617
increased keratinocyte apoptosis J:107589
increased leukocyte cell number J:83617
increased megakaryocyte cell number J:83617
increased monocyte cell number J:83617
increased neutrophil cell number J:83617
increased osteoblast cell number J:91765
increased pre-B cell number J:83617
increased pro-B cell number J:83617
increased systemic arterial blood pressure J:73898
increased vasoconstriction J:73898
myelofibrosis J:83617
neuron degeneration J:67862
prostate gland epithelial hyperplasia J:51663
reduced female fertility J:51663
normal reproductive system phenotype J:51663
normal skeleton phenotype J:62222
spleen hyperplasia J:83617
spleen hypoplasia J:110416
thin epidermis J:107589
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory