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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Esr2
estrogen receptor 2 (beta)
MGI:109392
73 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas * C57BL/6J 		abnormal enterocyte proliferation J:118600
increased gastrointestinal tumor incidence J:118600
ApcMin/Apc+
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6J 		abnormal colon goblet cell morphology J:118600
abnormal enterocyte proliferation J:118600
colitis J:118600
increased colon adenoma incidence J:118600
increased gastrointestinal tumor incidence J:118600
Esr1tm1.1Mma/Esr1+
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal response/metabolism to endogenous compounds J:64426
absent corpus luteum J:64426
impaired granulosa cell differentiation J:64426
increased tertiary ovarian follicle number J:64426
reduced female fertility J:64426
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal response/metabolism to endogenous compounds J:64426
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal ovarian follicle morphology J:64426
abnormal ovary morphology J:64426
abnormal response/metabolism to endogenous compounds J:64426
abnormal rete testis morphology J:64426
abnormal seminiferous tubule morphology J:64426
abnormal Sertoli cell morphology J:64426
abnormal tertiary ovarian follicle morphology J:64426
decreased male germ cell number J:64426
decreased theca cell number J:64426
impaired granulosa cell differentiation J:64426
increased atretic ovarian follicle number J:64426
male infertility J:64426
ovarian follicular cyst J:64426
small vagina J:64426
thin uterus J:64426
uterus hypoplasia J:64426
vagina hypoplasia J:64426
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd 		abnormal ovary morphology J:59105
abnormal vertebrae morphology J:111108
absent corpus luteum J:59105
asthenozoospermia J:59105
female infertility J:59105
increased body length J:111108
increased circulating luteinizing hormone level J:59105
long femur J:111108
male infertility J:59105
oligozoospermia J:59105
uterus hypoplasia J:59105
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell number J:82423
abnormal bone marrow cell number J:82423
abnormal class switch recombination J:82423
abnormal copulation behavior J:66582
abnormal immunoglobulin level J:82423
abnormal response/metabolism to endogenous compounds J:82423, J:115411
abnormal uterus weight J:115411
decreased aggression towards male mice J:66582
decreased areal bone mineral density J:62222
decreased body weight J:62222
decreased bone mineral content J:62222
decreased bone mineral density of femur J:62222
decreased CD4-positive, alpha-beta T cell number J:110416
decreased CD8-positive, alpha-beta T cell number J:110416
decreased circulating insulin-like growth factor I level J:62222
decreased circulating osteocalcin level J:62222
decreased compact bone area J:62222
decreased femoral compact bone area J:62222
decreased spleen weight J:110416
decreased uterus weight J:115411
failure of ejaculation J:66582
increased aggression towards female mice J:66582
increased circulating cholesterol level J:66077
increased circulating HDL cholesterol level J:66077
increased circulating leptin level J:66077
increased double-positive T cell number J:110416
increased gonadal fat pad weight J:66077
increased retroperitoneal fat pad weight J:66077
increased total body fat amount J:66077
insulin resistance J:66077
obese J:66077
short femur J:62222
thymus hypoplasia J:110416
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
Inhatm1Bay/Inha+
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal ovary morphology J:84989
increased ovary tumor incidence J:84989
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
Inhatm1Bay/Inhatm1Bay
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal ovary morphology J:84989
abnormal seminiferous tubule morphology J:84989
cachexia J:84989
decreased body weight J:84989
decreased circulating follicle stimulating hormone level J:84989
decreased male germ cell number J:84989
dilated seminiferous tubule J:84989
increased body weight J:84989
increased ovary tumor incidence J:84989
increased testis tumor incidence J:84989
premature death J:84989
Esr2tm1Unc/Esr2tm1Unc
Inhatm1Bay/Inhatm1Bay
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal liver morphology J:84989
abnormal stomach morphology J:84989
cachexia J:84989
increased ovary tumor incidence J:84989
increased testis tumor incidence J:84989
premature death J:84989
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory