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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
MGI:109482
15 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cacna1atg/Cacna1atg
Tg(Pcp2-TAg)4Horr/0
B6J.Cg-Cacna1atg Tg(Pcp2-TAg)4Horr 		ataxia J:233263
decreased Purkinje cell number J:233263
Cacna1atm1(CACNA1A)Ttan/Cacna1a+
involves: 129S4/SvJae 		impaired coordination J:123243
Cacna1atm1(CACNA1A)Ttan/Cacna1atm1(CACNA1A)Ttan
involves: 129S4/SvJae 		ataxia J:123243
dystonia J:123243
lethality at weaning, complete penetrance J:123243
Cacna1atm1.1(CACNA1A)Ttan/Cacna1atm1.1(CACNA1A)Ttan
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL 		ataxia J:123243
dystonia J:123243
lethality at weaning, complete penetrance J:123243
Cacna1atm1.1Kewa/Cacna1atm1.1Kewa
B6.Cg-Cacna1atm1.1Kewa 		no abnormal phenotype detected J:190729
Cacna1atm2.1Kewa/Cacna1a+
B6.Cg-Cacna1atm2.1Kewa 		abnormal motor coordination/balance J:190729
ataxia J:190729
Purkinje cell degeneration J:190729
Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
B6.Cg-Cacna1atm2.1Kewa 		abnormal gait J:190729
abnormal motor coordination/balance J:190729
abnormal nervous system electrophysiology J:190729
abnormal Purkinje cell dendrite morphology J:190729
abnormal Purkinje cell mitochondrial morphology J:190729
abnormal Purkinje cell morphology J:190729
ataxia J:190729
decreased Purkinje cell size J:190729
Purkinje cell degeneration J:190729
short stride length J:190729
Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Ctsbtm1Jde/Ctsb+
involves: 129P2/OlaHsd * C57BL/6 		abnormal motor coordination/balance J:190729
Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Ctsbtm1Jde/Ctsbtm1Jde
involves: 129P2/OlaHsd * C57BL/6 		abnormal motor coordination/balance J:190729
abnormal Purkinje cell morphology J:190729
Purkinje cell degeneration J:190729
Cacna1atm3Hzo/Cacna1atm3Hzo
Ctsbtm1Jde/Ctsbtm1Jde
involves: 129P2/OlaHsd * 129S/SvEv 		Purkinje cell degeneration J:190729
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory