Nfil3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfil3
nuclear factor, interleukin 3, regulated
MGI:109495

57 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Commd10^{Tg(Vav1-icre)A2Kio}/0 Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	decreased dendritic cell number	J:334296
Nfil3^{tm1.1(KOMP)Vlcg}/Nfil3^{tm1.1(KOMP)Vlcg} C57BL/6N-Nfil3^{tm1.1(KOMP)Vlcg}/Ucd	abnormal cecum morphology	J:211773
	abnormal cornea morphology	J:211773
	abnormal pancreas morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	cornea vascularization	J:211773
	decreased bone mineral content	J:211773
	enlarged spleen	J:211773
	increased spleen weight	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	small thymus	J:211773
Nfil3^tm1.1Brad/Nfil3⁺ B6.Cg-Nfil3^tm1.1Brad	decreased NK cell number	J:152774
Nfil3^tm1.1Brad/Nfil3^tm1.1Brad B6.Cg-Nfil3^tm1.1Brad	abnormal NK cell differentiation	J:152774
	decreased interferon-gamma secretion	J:152774
	decreased NK cell number	J:152774
	normal immune system phenotype	J:152774
	impaired natural killer cell mediated cytotoxicity	J:152774
	increased memory T cell number	J:152774
	increased NK T cell number	J:152774
Nfil3^tm1.1Kubo/Nfil3^tm1.1Kubo B6.Cg-Nfil3^tm1.1Kubo	abnormal interleukin secretion	J:184570
	decreased body weight	J:172134
	decreased interleukin-9 secretion	J:184570
	decreased interleukin-10 secretion	J:172134, J:184570
	decreased interleukin-13 secretion	J:172134, J:184570
	decreased interleukin-17 secretion	J:184570
	diarrhea	J:172134
	normal digestive/alimentary phenotype	J:340220
	increased susceptibility to experimental autoimmune encephalomyelitis	J:172134
	increased susceptibility to induced colitis	J:172134
Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo Tg(Itgax-cre)1-1Reiz/0 involves: 129 * C57BL/6 * CBA	normal hematopoietic system phenotype	J:334296
	normal immune system phenotype	J:334296
Nfil3^tm1Look/Nfil3^tm1Look B6.129X1-Nfil3^tm1Look	abnormal NK cell differentiation	J:155677
	decreased interferon-gamma secretion	J:155677
	decreased NK cell number	J:155677
	impaired natural killer cell mediated cytotoxicity	J:155677
Nfil3^tm1Look/Nfil3^tm1Look involves: 129X1/SvJ	normal immune system phenotype	J:209365
Nfil3^tm1Pbro/Nfil3^tm1Pbro B6.129S6-Nfil3^tm1Pbro	abnormal circulating cytokine level	J:209365
	abnormal colon goblet cell morphology	J:209365
	abnormal colon morphology	J:209365
	abnormal cytokine secretion	J:209365
	abnormal leukocyte morphology	J:209365
	abnormal plasma cell morphology	J:209365
	colitis	J:209365
	decreased NK cell number	J:209365
	increased circulating interferon-gamma level	J:209365
	increased circulating interleukin-10 level	J:209365
	increased circulating interleukin-12b level	J:209365
	increased circulating interleukin-17 level	J:209365
	increased circulating tumor necrosis factor level	J:209365
	increased interferon-gamma secretion	J:209365
	increased interleukin-10 secretion	J:209365
	increased interleukin-12b secretion	J:209365
	increased interleukin-17 secretion	J:209365
	increased macrophage cytokine production	J:209365
	increased T-helper 17 cell number	J:209365
	increased tumor necrosis factor secretion	J:209365
	intestinal ulcer	J:209365
	rectal prolapse	J:209365
Nfil3^tm1Pbro/Nfil3^tm1Pbro involves: 129S6/SvEvTac * C57BL/6	abnormal class switch recombination	J:156521
	decreased IgE level	J:156521
	decreased IgG1 level	J:156521
	decreased interleukin-4 secretion	J:156521
	normal immune system phenotype	J:156521
Tg(Igh-Nfil3)#Kubo/0 B6.Cg-Tg(Igh-Nfil3)#Kubo	increased interleukin-3 secretion	J:172134
	increased interleukin-10 secretion	J:172134
	increased interleukin-13 secretion	J:172134

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