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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sftpd
surfactant associated protein D
MGI:109515
29 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sftpdtm1Haw/Sftpdtm1Haw
involves: C57BL/6J * CD-1 		abnormal alveolar macrophage morphology J:50147, J:98220
abnormal cholesterol homeostasis J:50147
abnormal lung morphology J:50147
abnormal macrophage physiology J:98220
abnormal pulmonary alveolus epithelium morphology J:98220
abnormal pulmonary alveolus morphology J:50147
abnormal surfactant physiology J:98220
abnormal surfactant secretion J:98220
emphysema J:98220
enlarged alveolar lamellar bodies J:50147, J:98220
increased type II pneumocyte number J:50147, J:98220
normal mortality/aging J:50147
overexpanded pulmonary alveolus J:50147, J:98220
thick pulmonary interalveolar septum J:98220
Sftpdtm1Jhf/Sftpdtm1Jhf
involves: 129P2/OlaHsd * Black Swiss 		abnormal alveolar macrophage morphology J:50436
abnormal chemokine level J:72681
abnormal cytokine level J:62282, J:72681
abnormal lipid homeostasis J:50436
abnormal lung morphology J:50436, J:62282
abnormal lung volume J:62282
abnormal macrophage morphology J:50436, J:62282
abnormal macrophage physiology J:62282
abnormal neutrophil physiology J:72681
abnormal pulmonary alveolus morphology J:50436
abnormal pulmonary elastic fiber morphology J:62282
abnormal surfactant composition J:72681
abnormal surfactant secretion J:72681
decreased body weight J:62282
emphysema J:62282
increased macrophage cell number J:50436, J:62282
increased neutrophil cell number J:72681
increased susceptibility to Orthomyxoviridae infection J:72681
lung inflammation J:50436, J:62282
normal mortality/aging J:50436, J:130297
overexpanded pulmonary alveolus J:50436, J:62282
pulmonary fibrosis J:62282
thick pulmonary interalveolar septum J:62282
weight loss J:72681
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory