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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
MGI:109520
34 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pafah1b1Gt(IRESBetageo)1Hha/Pafah1b1Gt(IRESBetageo)1Hha
involves: 129/Sv * NMRI 		abnormal acrosome morphology J:86720
abnormal germ cell morphology J:86720
abnormal seminiferous tubule morphology J:86720
abnormal spermatid morphology J:86720
abnormal spermatogonia morphology J:86720
abnormal spermiation J:86720
abnormal spermiogenesis J:86720
abnormal testis morphology J:86720
arrest of spermiogenesis J:86720
azoospermia J:86720
male infertility J:86720
small testis J:86720
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S6/SvEvTac 		abnormal hippocampus pyramidal cell layer J:129338
abnormal neocortex morphology J:100552
abnormal neuronal migration J:100552
increased neuron apoptosis J:100552
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal hippocampus morphology J:49531
abnormal olfactory bulb morphology J:49531
abnormal spatial learning J:59817
abnormal stratification in cerebral cortex J:49531
delayed brain development J:49531
enlarged brain ventricles J:49531
impaired coordination J:59817
limb grasping J:59817
Pafah1b1tm1Awb/Pafah1b1tm1Awb
involves: 129S6/SvEvTac 		embryonic lethality at implantation, complete penetrance J:197131
Pafah1b1tm1Awb/Pafah1b1tm1Awb
involves: 129S6/SvEvTac * NIH Black Swiss 		embryonic lethality, complete penetrance J:49531
Pafah1b1tm1Awb/Pafah1b1tm2Awb
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss 		abnormal dentate gyrus morphology J:49531
abnormal hippocampus pyramidal cell layer J:49531
abnormal stratification in cerebral cortex J:49531
absent hippocampus stratum oriens J:49531
decreased body size J:49531
ectopic Purkinje cell J:49531
postnatal lethality, complete penetrance J:49531
Pafah1b1tm1Or/Pafah1b1+
Not Specified 		abnormal radial glial cell morphology J:69631
abnormal telencephalon development J:69631
delayed brain development J:69631
Pafah1b1tm1Or/Pafah1b1tm1Or
Not Specified 		embryonic lethality between implantation and somite formation, complete penetrance J:69631
Pafah1b1tm2.2Awb/Pafah1b1+
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal hippocampus morphology J:49531
abnormal olfactory bulb morphology J:49531
abnormal stratification in cerebral cortex J:49531
enlarged brain ventricles J:49531
Pafah1b1tm2.2Awb/Pafah1b1tm2.2Awb
involves: 129S6/SvEvTac * NIH Black Swiss 		embryonic lethality, complete penetrance J:49531
Pafah1b1tm2Awb/Pafah1b1tm2Awb
involves: 129S/SvEv * FVB/N * NIH Black Swiss 		abnormal hippocampus morphology J:49531
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory