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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
MGI:109520
26 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Braptm1.1Yfng/Braptm1.1Yfng
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal mitosis J:197131
abnormal roof plate morphology J:197131
decreased embryo size J:197131
embryonic lethality during organogenesis J:197131
Lrp8tm1Her/Lrp8tm1Her
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebral cortex morphology J:129338
abnormal hippocampus layer morphology J:129338
Nde1tm1Caw/Nde1tm1Caw
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S4/SvJae * 129S6/SvEvTac 		abnormal dorsal interneuron morphology J:197131
abnormal roof plate morphology J:197131
abnormal spinal cord dorsal horn morphology J:197131
abnormal spinal cord morphology J:197131
abnormal spinal cord ventral horn morphology J:197131
choroid plexus hyperplasia J:197131
decreased neuron number J:197131
normal nervous system phenotype J:197131
Pafah1b1tm1Awb/Pafah1b1+
Vldlrtm1Her/Vldlrtm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		normal nervous system phenotype J:129338
Pafah1b1tm1Awb/Pafah1b1+
Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Pafah1b3tm1Cla/Pafah1b3tm1Cla
involves: 129S6/SvEvTac 		abnormal seminiferous tubule epithelium morphology J:83818
decreased male germ cell number J:83818
decreased testis weight J:83818
multinucleated giant male germ cells J:83818
normal reproductive system phenotype J:83818
Pafah1b1tm1Awb/Pafah1b1+
Ywhaetm1Awb/Ywhae+
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss) 		abnormal brain morphology J:84075
abnormal hippocampus morphology J:84075
decreased neuronal migration J:84075
Pafah1b1tm1Awb/Pafah1b1+
Ndel1tm1.1Shr/Ndel1+
involves: 129S6/SvEvTac 		abnormal neocortex morphology J:100552
abnormal neuronal migration J:100552
abnormal telencephalon development J:100552
increased neuron apoptosis J:100552
Pafah1b1tm2.2Awb/Pafah1b1+
Ndel1tm1.1Shr/Ndel1+
involves: 129S6/SvEvTac 		abnormal hippocampus pyramidal cell morphology J:100552
abnormal telencephalon development J:100552
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory