Trpc6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trpc6
transient receptor potential cation channel, subfamily C, member 6
MGI:109523

13 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(NPHS2-Trpc6)F419Walz/0 involves: C57BL/6J * CBA/J	abnormal glomerular mesangium morphology	J:165112
	abnormal perihilar interstitium morphology	J:165112
	abnormal renal glomerulus morphology	J:165112
	albuminuria	J:165112
	glomerulosclerosis	J:165112
	increased renal glomerulus basement membrane thickness	J:165112
	podocyte foot process effacement	J:165112
Tg(NPHS2-Trpc6E896K)F75aWalz/0 involves: C57BL/6J CBA/J	abnormal glomerular mesangium morphology	J:165112
	abnormal perihilar interstitium morphology	J:165112
	abnormal renal glomerulus morphology	J:165112
	albuminuria	J:165112
	glomerulosclerosis	J:165112
	increased renal glomerulus basement membrane thickness	J:165112
	podocyte foot process effacement	J:165112
Tg(NPHS2-Trpc6P111Q)F615Walz/0 involves: C57BL/6J CBA/J	abnormal glomerular mesangium morphology	J:165112
	abnormal perihilar interstitium morphology	J:165112
	abnormal renal glomerulus morphology	J:165112
	albuminuria	J:165112
	glomerulosclerosis	J:165112
	increased renal glomerulus basement membrane thickness	J:165112
	podocyte foot process effacement	J:165112
Trpc6^tm1Dgen/Trpc6^tm1Dgen involves: 129P2/OlaHsd * C57BL/6J	increased thermal nociceptive threshold	J:82809
Trpc6^tm1Lbi/Trpc6^tm1Lbi involves: 129S/SvEv	abnormal eye physiology	J:176849
Trpc6^tm1Lbi/Trpc6^tm1Lbi involves: 129S/SvEv * C57BL/6J	abnormal vascular smooth muscle physiology	J:106082
	abnormal vasoconstriction	J:106082
	increased systemic arterial blood pressure	J:106082
	increased vasoconstriction	J:106082

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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