Trpc5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trpc5
transient receptor potential cation channel, subfamily C, member 5
MGI:109524

17 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺ Trpc5^tm1.1Mfre/Trpc5^tm1.1Mfre involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N * SJL	abnormal action potential	J:277600
	abnormal estrus	J:277600
	decreased circulating luteinizing hormone level	J:277600
	decreased circulating prolactin level	J:277600
	decreased litter size	J:277600
	decreased ovulation rate	J:277600
	prolonged diestrus	J:277600
	prolonged estrous cycle	J:277600
	reduced female fertility	J:277600
Trpc5^tm1.1Clph/Y involves: 129S1/SvImJ	abnormal excitatory postsynaptic currents	J:148915
	decreased anxiety-related response	J:148915
	decreased fear-related response	J:148915
	increased fear-related response	J:148915
Trpc5^tm1.1Clph/Trpc5^tm1.1Clph involves: 129S1/SvImJ	abnormal action potential	J:277600
	abnormal excitatory postsynaptic currents	J:148915
	decreased anxiety-related response	J:148915
	decreased circulating prolactin level	J:277600
	decreased fear-related response	J:148915
	decreased litter size	J:277600
	increased fear-related response	J:148915
	prolonged estrous cycle	J:277600
	reduced female fertility	J:277600
Trpc5^tm1.1Lbi/Y involves: 129S6/SvEvTac * C57BL/6 * CBA	normal behavior/neurological phenotype	J:194590
	decreased susceptibility to neuronal excitotoxicity	J:194590
	decreased susceptibility to pharmacologically induced seizures	J:194590
	reduced long-term potentiation	J:194590
Trpc5^tm1.1Lbi/Trpc5^tm1.1Lbi involves: 129S6/SvEvTac * C57BL/6 * CBA	normal behavior/neurological phenotype	J:194590
	decreased susceptibility to neuronal excitotoxicity	J:194590
	decreased susceptibility to pharmacologically induced seizures	J:194590
	reduced long-term potentiation	J:194590
Trpc5^tm1.2Mfre/Trpc5^tm1.2Mfre B6N.129-Trpc5^tm1.2Mfre	abnormal action potential	J:277600
	decreased circulating prolactin level	J:277600
	decreased litter size	J:277600
	prolonged estrous cycle	J:277600
	reduced female fertility	J:277600

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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