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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bmpr2
bone morphogenetic protein receptor type 2
MGI:1095407
75 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bmpr2b2b2556Clo/Bmpr2b2b2556Clo
C57BL/6J-Bmpr2b2b2556Clo 		abnormal myocardium compact layer morphology J:175213
abnormal semilunar valve morphology J:175213
atrioventricular septal defect J:175213
hydronephrosis J:175213
muscular ventricular septal defect J:175213
persistent truncus arteriosus type i J:175213
persistent truncus arteriosus type iv J:175213
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
involves: 129S4/SvJae * C57BL/6 * FVB/N 		no abnormal phenotype detected J:97109
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(Acvrl1-cre)L1Spo/0
involves: 129S4/SvJae * FVB 		abnormal lung thrombosis J:158116
abnormal lung vasculature morphology J:158116
abnormal pulmonary artery morphology J:158116
artery occlusion J:158116
heart right ventricle hypertrophy J:158116
increased lung endothelial cell proliferation J:158116
increased pulmonary artery pressure J:158116
increased vascular smooth muscle cell proliferation J:158116
pulmonary hypertension J:158116
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(KRT14-cre)1Ipc/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal hair medulla J:189569
abnormal hair medullary septa cells J:189569
abnormal hair shaft melanin granule distribution J:189569
normal integument phenotype J:189569
Bmpr2tm1.1Enl/Bmpr2tm1.2Enl
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJae * C57BL/6J * CBA/J 		abnormal ophthalmic nerve morphology J:206541
normal nervous system phenotype J:206541
Bmpr2tm1.1Enl/Bmpr2tm1Kmi
Tg(KRT14-cre)1Ipc/0
involves: 129S4/SvJae * C57BL/6 * SJL 		no abnormal phenotype detected J:189569
Bmpr2tm1.1Pley/Bmpr2+
B6.Cg-Bmpr2tm1.1Pley 		normal cardiovascular system phenotype J:209027
Bmpr2tm1.1Pley/Bmpr2tm1.1Pley
B6.Cg-Bmpr2tm1.1Pley 		embryonic lethality between implantation and placentation, incomplete penetrance J:209027
Bmpr2tm1.2Enl/Bmpr2tm1.2Enl
involves: 129S4/SvJae * C57BL/6 		embryonic growth retardation J:97109
embryonic lethality between implantation and somite formation, complete penetrance J:97109
Bmpr2tm1Enl/Bmpr2tm1Enl
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:97109
Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae 		abnormal sternocostal joint morphology J:95124
vertebral transformation J:95124
Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae * C57BL/6 		abnormal lung vasculature morphology J:98219
abnormal pulmonary alveolus morphology J:98219
abnormal pulmonary artery morphology J:98219
increased pulmonary artery pressure J:98219
increased pulmonary vascular resistance J:98219
pulmonary hypertension J:98219
Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae * C57BL/6J 		abnormal leukocyte physiology J:117167
abnormal lung vasculature morphology J:117167
increased vasoconstriction J:117167
perinatal lethality, incomplete penetrance J:117167
prenatal lethality, incomplete penetrance J:117167
pulmonary hypertension J:117167
Bmpr2tm1Kmi/Bmpr2tm1Kmi
involves: 129S4/SvJae * C57BL/6J 		abnormal egg cylinder morphology J:61931
abnormal embryonic epiblast morphology J:61931
abnormal embryonic-extraembryonic boundary morphology J:61931
abnormal rostral-caudal axis patterning J:61931
absent mesoderm J:61931
disorganized embryonic tissue J:61931
disorganized extraembryonic tissue J:61931
embryonic growth arrest J:61931
embryonic growth retardation J:61931
embryonic lethality during organogenesis, complete penetrance J:61931
failure of primitive streak formation J:61931
failure to gastrulate J:61931
Bmpr2tm1Kml/Bmpr2tm1Kml
either: (involves: 129X1/SvJ * BALB/cJ) or (involves: 129X1/SvJ * C57BL/6J) 		abnormal interventricular septum morphology J:80024
abnormal semilunar valve morphology J:80024
absent vitelline blood vessels J:80024
decreased rib number J:80024
delayed bone ossification J:80024
interrupted aortic arch J:80024
lethality throughout fetal growth and development, complete penetrance J:80024
Bmpr2tm1Mmue/Bmpr2+
B6.129S1-Bmpr2tm1Mmue 		abnormal pulmonary artery morphology J:224752
increased right ventricle systolic pressure J:224752
increased vascular permeability J:224752
pulmonary hypertension J:224752
Bmpr2tm1Mmue/Bmpr2tm1Mmue
B6.129S1-Bmpr2tm1Mmue 		lethality, complete penetrance J:224752
Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
involves: 129 * C57BL/6J 		abnormal blood vessel morphology J:145514
abnormal pulmonary artery morphology J:145514
abnormal spleen morphology J:145514
abnormal spleen white pulp morphology J:145514
anemia J:145514
cachexia J:145514
decreased angiogenesis J:145514
decreased erythrocyte cell number J:145514
enlarged spleen J:145514
extramedullary hematopoiesis J:145514
normal homeostasis/metabolism phenotype J:145514
intestinal hemorrhage J:145514
intestine polyps J:145514
pallor J:145514
premature death J:145514
respiratory distress J:145514
reticulocytosis J:145514
normal skeleton phenotype J:145514
vascular smooth muscle hypoplasia J:145514
Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
involves: 129 * C57BL/6J 		gastrointestinal hemorrhage J:145514
premature death J:145514
Tg(Tagln-rtTA)E1Jwst/0
Tg(tetO-Bmpr2*R899X)#Jwst/0
involves: FVB/N 		abnormal lung vasculature morphology J:164503
heart right ventricle hypertrophy J:164503
increased body weight J:164503
increased right ventricle systolic pressure J:164503
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory