Unc5c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Unc5c
unc-5 netrin receptor C
MGI:1095412

30 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Unc5c^{em2(IMPC)Rbrc}/Unc5c⁺ C57BL/6NJcl-Unc5c^{em2(IMPC)Rbrc}/Rbrc	decreased locomotor activity	J:211773
Unc5c^{em2(IMPC)Rbrc}/Unc5c^{em2(IMPC)Rbrc} C57BL/6NJcl-Unc5c^{em2(IMPC)Rbrc}/Rbrc	preweaning lethality, complete penetrance	J:211773
Unc5c^{rcmTg(Tert)5Hwl}/Unc5c^{rcmTg(Tert)5Hwl} involves: FVB/N	abnormal cerebellum development	J:85446
	abnormal corpora quadrigemina morphology	J:85446
	abnormal epididymal fat pad morphology	J:85446
	abnormal fat pad morphology	J:85446
	abnormal gait	J:85446
	ataxia	J:85446
	decreased body size	J:85446
	decreased body weight	J:85446
	hyperactivity	J:85446
	increased fluid intake	J:85446
	increased food intake	J:85446
	increased locomotor activity	J:85446
	small cerebellum	J:85446
Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}	abnormal phrenic nerve innervation pattern to diaphragm	J:109043
	abnormal phrenic nerve morphology	J:109043
	abnormal trochlear nerve morphology	J:109043
	preweaning lethality, complete penetrance	J:109043
Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} involves: C57BL/6J * SJL/J	abnormal cerebellar lobule formation	J:40243
	abnormal cerebellar Purkinje cell layer	J:40243
	abnormal cerebellum development	J:40243, J:45577
	abnormal cerebellum external granule cell layer morphology	J:40243
	abnormal corticospinal tract morphology	J:80430
	abnormal inferior colliculus morphology	J:40243
	abnormal innervation pattern to muscle	J:109043
	abnormal pyramidal decussation morphology	J:80430
	abnormal spinal cord dorsal column morphology	J:80430
	abnormal trochlear nerve morphology	J:109043
	ataxia	J:40243
	ectopic cerebellar granule cells	J:40243, J:45577
	ectopic Purkinje cell	J:40243, J:45577
	normal mortality/aging	J:109043
	reduced cerebellar foliation	J:40243
	small cerebellum	J:40243

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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