About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Jag1
jagged 1
MGI:1095416
138 phenotypes from 12 alleles in 22 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Jag1Gt(betageo)1Byg/Jag1+
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:146621
Jag1Mhdahtu/Jag1+
C3HeB/FeJ-Jag1Mhdahtu 		abnormal cochlear hair cell morphology J:72108
abnormal crista ampullaris morphology J:72108, J:149467
abnormal organ of Corti morphology J:72108
abnormal semicircular canal ampulla morphology J:72108
abnormal semicircular canal morphology J:72108
decreased cochlear outer hair cell number J:72108
head shaking J:72108
head tossing J:86685
normal hearing/vestibular/ear phenotype J:72108
increased cochlear inner hair cell number J:72108
Jag1Mhdahtu/Jag1Mhdahtu
C3HeB/FeJ-Jag1Mhdahtu 		abnormal blood vessel morphology J:72108
abnormal vitelline vasculature morphology J:72108
embryonic growth retardation J:72108
embryonic lethality during organogenesis, complete penetrance J:72108
enlarged pericardium J:72108
hemorrhage J:72108
kinked neural tube J:72108
Jag1Mhdahtu/Jag1Slalom
involves: BALB/c * C3H * C3HeB/FeJ 		abnormal vitelline vasculature morphology J:72108
embryo tissue necrosis J:72108
embryonic lethality during organogenesis J:72108
hemorrhage J:72108
Jag1Ndr/Jag1+
involves: C3HeB/FeJ 		head bobbing J:156172
impaired balance J:156172
Jag1Ndr/Jag1Ndr
involves: C3HeB/FeJ 		abnormal neuron differentiation J:156172
abnormal vascular development J:277896
decreased embryo size J:277896
decreased neuronal precursor cell number J:156172
embryonic lethality during organogenesis, complete penetrance J:156172, J:277896
hemorrhage J:277896
increased neuron number J:156172
pale yolk sac J:277896
pallor J:277896
Jag1Ndr/Jag1Ndr
involves: C3HeB/FeJ * C57BL/6 		abnormal bile duct development J:277897
abnormal bile duct morphology J:277897
abnormal cholangiocyte morphology J:277897
abnormal feces composition J:277897
abnormal iris morphology J:277897
abnormal liver morphology J:277897
abnormal liver physiology J:277897
abnormal liver vasculature morphology J:277897
atrial septal defect J:277897
decreased body size J:277897
decreased body weight J:277897
decreased circulating serum albumin level J:277897
increased circulating alkaline phosphatase level J:277897
increased circulating aspartate transaminase level J:277897
increased circulating bilirubin level J:277897
jaundice J:277897
lethality throughout fetal growth and development, incomplete penetrance J:277897
lethality, incomplete penetrance J:277897
microphthalmia J:277897
postnatal lethality, incomplete penetrance J:277897
premature death J:277897
short snout J:277897
slow postnatal weight gain J:277897
small lens J:277897
ventricular septal defect J:277897
Jag1Ozz/Jag1+
involves: BALB/cOla * C3H 		circling J:82809
head bobbing J:83917
head shaking J:82809
Jag1Ozz/Jag1Ozz
involves: BALB/cOla * C3H 		head bobbing J:83917
Jag1Slalom/Jag1+
involves: BALB/c * C3H 		abnormal cochlear sensory epithelium morphology J:67728
abnormal semicircular canal ampulla morphology J:67728
abnormal semicircular canal morphology J:67728
decreased cochlear outer hair cell number J:67728
head shaking J:67728
increased cochlear inner hair cell number J:67728
positive geotaxis J:67728
Jag1Slalom/Jag1Slalom
involves: BALB/c * C3H 		abnormal neural tube morphology J:67728
abnormal vitelline vasculature morphology J:67728
embryonic lethality during organogenesis, complete penetrance J:67728
Jag1tm1.1Loo/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:149131
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
involves: 129/Sv * C57BL/6 * CD-1 		normal renal/urinary system phenotype J:198632
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia 		abnormal aorta morphology J:189213
abnormal cardiac outflow tract development J:189213
abnormal coronary vessel morphology J:189213
abnormal heart morphology J:189213
abnormal heart valve morphology J:189213
abnormal pulmonary trunk morphology J:189213
calcified aortic valve J:189213
dilated heart J:189213
heart right ventricle hypertrophy J:189213
increased heart right atrium size J:189213
increased heart right ventricle size J:189213
increased heart right ventricle wall thickness J:189213
increased systemic arterial systolic blood pressure J:189213
normal liver/biliary system phenotype J:166890
normal mortality/aging J:166890
overriding aortic valve J:189213
pulmonary valve regurgitation J:189213
pulmonary valve stenosis J:189213
thick heart valve cusps J:189213
ventricular septal defect J:189213
Jag1tm1Frad/Jag1tm1Frad
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA 		normal hematopoietic system phenotype J:98129
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
involves: 129/Sv * C57BL/6 * CD-1 		decreased nephron number J:198632
Jag1tm1Frad/Jag1tm1Frad
Tg(Tagln-cre)1Her/0
B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her 		abnormal bile duct development J:166890
abnormal bile duct morphology J:166890
abnormal bile secretion J:166890
alopecia J:166890
cholestasis J:166890
decreased body weight J:166890
hepatic necrosis J:166890
increased circulating alanine transaminase level J:166890
increased circulating alkaline phosphatase level J:166890
increased circulating aspartate transaminase level J:166890
increased circulating bilirubin level J:166890
increased circulating cholesterol level J:166890
increased circulating gamma-glutamyl transferase level J:166890
increased circulating lactate dehydrogenase level J:166890
jaundice J:166890
lethargy J:166890
liver hemorrhage J:166890
neonatal lethality, incomplete penetrance J:166890
postnatal growth retardation J:166890
postnatal lethality, incomplete penetrance J:166890
Jag1tm1Grid/Jag1+
involves: 129S1/Sv * C57BL/6 * FVB 		abnormal eye morphology J:54907
abnormal placement of pupils J:54907
cornea opacity J:54907
iris coloboma J:54907
irregularly shaped pupil J:54907
Jag1tm1Grid/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal bile secretion J:149131
bile duct proliferation J:149131
dilated bile duct J:149131
Jag1tm1Grid/Jag1tm1Grid
involves: 129S1/Sv * C57BL/6 * FVB 		abnormal vascular development J:54907
abnormal vitelline vascular remodeling J:54907
embryonic lethality during organogenesis, complete penetrance J:54907
hemorrhage J:54907
pale yolk sac J:54907
Jag1tm1Grid/Jag1tm2Grid
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal cochlea morphology J:115783
abnormal cochlear hair cell morphology J:115783
abnormal cochlear hair cell number J:115783
abnormal cochlear outer hair cell morphology J:115783
abnormal crista ampullaris morphology J:115783
abnormal lateral semicircular canal morphology J:115783
abnormal superior semicircular canal morphology J:115783
abnormal utricular macula morphology J:115783
abnormal vestibular saccule morphology J:115783
absent cochlear hair cells J:115783
absent semicircular canals J:115783
absent tunnel of Corti J:115783
decreased cochlea coiling J:115783
normal hearing/vestibular/ear phenotype J:115783
perinatal lethality, complete penetrance J:115783
small utricle J:115783
Jag1tm1Grid/Jag1tm2Grid
Tg(Tagln-cre)1Her/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal vascular smooth muscle morphology J:166769
cyanosis J:166769
patent ductus arteriosus J:166769
perinatal lethality, incomplete penetrance J:166769
postnatal lethality, complete penetrance J:166769
retroesophageal right subclavian artery J:166769
Jag1tm1Jlew/Jag1tm1Grid
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal angiogenesis J:157345
abnormal blood vessel morphology J:157345
abnormal retina vasculature morphology J:157345
normal cardiovascular system phenotype J:157345
decreased angiogenesis J:157345
postnatal growth retardation J:157345
Jag1tm1Jlew/Jag1tm1Jlew
involves: C57BL/6J 		abnormal cochlear hair cell morphology J:107414
abnormal semicircular canal morphology J:107414
abnormal utricular macula morphology J:107414
absent cochlear outer hair cells J:107414
absent vestibular hair cells J:107414
increased cochlear inner hair cell number J:107414
Jag1tm1Jlew/Jag1tm1Jlew
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: C57BL/6 * CBA 		decreased angiogenesis J:157345
Jag1tm1Jlew/Jag1tm1Jlew
Tg(Tie1-cre)9Ref/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal vascular branching morphogenesis J:157345
fetal growth retardation J:157345
Jag1tm2.1Grid/Jag1tm2.1Grid
involves: 129S1/Sv * C57BL/6 		abnormal vitelline vascular remodeling J:115783
distended pericardium J:115783
embryonic lethality during organogenesis, complete penetrance J:115783
intracranial hemorrhage J:115783
Jag1tm2Grid/Jag1tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal blood vessel morphology J:181120
abnormal eating behavior J:181120
abnormal palate morphology J:181120
abnormal primary palate development J:181120
decreased body size J:181120
decreased palatal length J:181120
malocclusion J:181120
midface hypoplasia J:181120
premature death J:181120
short maxilla J:181120
Jag1tm2Grid/Jag1tm2Grid
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 		abnormal vascular smooth muscle morphology J:166769
abnormal vitelline vascular remodeling J:166769
embryonic lethality during organogenesis, complete penetrance J:166769
hemorrhage J:166769
pericardial edema J:166769
Jag1Yo/Jag1+
C3HeB/FeJ-Jag1Yo 		abnormal posterior semicircular canal morphology J:82809
abnormal superior semicircular canal morphology J:82809
decreased cochlear outer hair cell number J:82809
Jag1Yo/Jag1Yo
C3HeB/FeJ-Jag1Yo 		embryonic lethality during organogenesis, complete penetrance J:82809
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory