Dnm2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnm2
dynamin 2
MGI:109547

71 phenotypes from 9 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dnm2^b2b2159Clo/Dnm2^b2b2159Clo C57BL/6J-Dnm2^b2b2159Clo	aorta hypoplasia	J:175213
	cleft palate	J:175213
	double outlet right ventricle	J:175213
	encephalomeningocele	J:175213
	hydrocephaly	J:175213
	hydronephrosis	J:175213
	microphthalmia	J:175213
	muscular ventricular septal defect	J:175213
	overriding aortic valve	J:175213
	perimembraneous ventricular septal defect	J:175213
	polycystic kidney	J:175213
	vascular ring	J:175213
	ventricular septal defect	J:175213
Dnm2^Rbc12/Dnm2⁺ involves: C57BL/6	abnormal bone marrow cell physiology	J:330452
	abnormal erythrocyte morphology	J:330452
	abnormal proerythroblast morphology	J:330452
	decreased hematocrit	J:330452
	decreased hemoglobin content	J:330452
	decreased mean corpuscular hemoglobin	J:330452
	normal homeostasis/metabolism phenotype	J:330452
	microcytic anemia	J:330452
Dnm2^Rbc12/Dnm2^Rbc12 involves: C57BL/6	embryonic lethality prior to organogenesis	J:330452
Dnm2^{tm1.1(KOMP)Vlcg}/Dnm2⁺ C57BL/6N-Dnm2^{tm1.1(KOMP)Vlcg}/Ucd	decreased mean corpuscular hemoglobin	J:211773
	enlarged uterus	J:211773
	hydrometra	J:211773
	increased circulating alkaline phosphatase level	J:211773
	small superior vagus ganglion	J:211773
Dnm2^{tm1.1(KOMP)Vlcg}/Dnm2^{tm1.1(KOMP)Vlcg} C57BL/6N-Dnm2^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Dnm2^tm1.1Ics/Dnm2⁺ involves: 129S2/SvPas	anemia	J:330452
Dnm2^tm1.1Ics/Dnm2⁺ involves: 129S2/SvPas * C57BL/6	abnormal calcium ion homeostasis	J:237196
	abnormal muscle contractility	J:237196
	abnormal skeletal muscle fiber morphology	J:166364
	decreased skeletal muscle fiber diameter	J:166364
	decreased skeletal muscle fiber size	J:166364
	decreased skeletal muscle mass	J:166364
	increased skeletal muscle fiber size	J:166364
	increased skeletal muscle mass	J:166364
	muscle weakness	J:166364
	muscular atrophy	J:166364
Dnm2^tm1.1Ics/Dnm2^tm1.1Ics involves: 129S2/SvPas * C57BL/6	abnormal cell physiology	J:166364
	abnormal skeletal muscle fiber morphology	J:166364
	centrally nucleated skeletal muscle fibers	J:166364
	decreased birth weight	J:166364
	decreased skeletal muscle fiber size	J:166364
	lethality at weaning, incomplete penetrance	J:166364
	neonatal lethality, incomplete penetrance	J:166364
	postnatal growth retardation	J:166364
Dnm2^tm1.1Pdc/Dnm2^tm1.1Pdc involves: 129S1/SvImJ * C57BL/6 * SJL	no abnormal phenotype detected	J:161127
Dnm2^tm1.2Pdc/Dnm2⁺ involves: 129S1/SvImJ * C57BL/6	normal hematopoietic system phenotype	J:330452
Dnm2^tm1.2Pdc/Dnm2^tm1.2Pdc involves: 129S1/SvImJ * C57BL/6 * FVB/N * SJL	embryonic lethality, complete penetrance	J:161127
Dnm2^tm1Ueli/Dnm2^tm2.1Ics Tg(Mpz-cre)26Mes/0 involves: C57BL/6J * C57BL/6N * FVB/NTac	abnormal action potential	J:288372
	decreased nerve conduction velocity	J:288372
	demyelination	J:288372
Dnm2^tm2.1Ics/Dnm2⁺ involves: C57BL/6J	abnormal action potential	J:288372
	abnormal gait	J:288372
	abnormal muscle electrophysiology	J:288372
	abnormal neuromuscular synapse morphology	J:288372
	abnormal skeletal muscle fiber morphology	J:288372
	abnormal skeletal muscle fiber type ratio	J:288372
	normal behavior/neurological phenotype	J:288372
	decreased locomotor activity	J:288372
	decreased skeletal muscle fiber diameter	J:288372
	decreased skeletal muscle weight	J:288372
	decreased total tissue mass	J:288372
	normal immune system phenotype	J:288372
	increased macrophage cell number	J:288372
	increased myelin sheath thickness	J:288372
	myopathy	J:288372
	short stride length	J:288372
Dnm2^tm4.1Ics/Dnm2⁺ involves: C57BL/6N	abnormal mitochondrial crista morphology	J:329580
	abnormal mitochondrial shape	J:329580
	abnormal skeletal muscle fiber morphology	J:329580
	decreased body weight	J:329580
	decreased food intake	J:329580
	decreased grip strength	J:329580
	decreased skeletal muscle fiber size	J:329580
	normal homeostasis/metabolism phenotype	J:329580
	increased mitochondrial size	J:329580
	preweaning lethality, incomplete penetrance	J:329580
Dnm2^tm4.1Ics/Dnm2^tm4.1Ics involves: C57BL/6N	abnormal skeletal muscle fiber morphology	J:329580
Dnm2^tm4.1Ics/Dnm2^tm4.1Ics involves: C57BL/6N	perinatal lethality, complete penetrance	J:329580

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