Adam10 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adam10
a disintegrin and metallopeptidase domain 10
MGI:109548

61 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adam10^tm1.1Dhc/Adam10^tm1.1Dhc Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	abnormal B cell differentiation	J:158127
	absent marginal zone B cells	J:158127
	decreased transitional stage T2 B cell number	J:158127
	increased follicular B cell number	J:158127
	increased transitional stage T1 B cell number	J:158127
Adam10^tm1.1Khr/Adam10^tm1.1Khr involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:179060
Adam10^tm1.1Khr/Adam10^tm1.1Khr Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N	abnormal bone marrow morphology	J:179060
	abnormal definitive hematopoiesis	J:179060
	abnormal granulocyte differentiation	J:179060
	abnormal spleen morphology	J:179060
	abnormal T cell differentiation	J:179060
	decreased CD4-positive, alpha-beta T cell number	J:179060
	decreased CD8-positive, alpha-beta T cell number	J:179060
	decreased double-positive T cell number	J:179060
	decreased erythrocyte cell number	J:179060
	decreased hematocrit	J:179060
	decreased hemoglobin content	J:179060
	decreased T cell number	J:179060
	enlarged spleen	J:179060
	increased hematopoietic stem cell number	J:179060
	increased leukocyte cell number	J:179060
	increased neutrophil cell number	J:179060
	increased spleen red pulp amount	J:179060
	increased spleen weight	J:179060
	myeloid hyperplasia	J:179060
	small thymus	J:179060
	spleen hyperplasia	J:179060
	thymus hypoplasia	J:179060
Adam10^tm1.1Zhu/Adam10^tm1.1Zhu involves: 129S6/SvEvTac * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:139042
Adam10^tm1Beni/Adam10^tm1Beni Tg(Pf4-icre)Q3Rsko/0 involves: 129/Sv * C57BL/6	abnormal platelet physiology	J:165863
Adam10^tm1Psa/Adam10^tm1Psa either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	abnormal forebrain development	J:94943
	abnormal neural tube morphology	J:94943
	abnormal paraxial mesoderm morphology	J:94943
	abnormal pontine flexure morphology	J:94943
	abnormal somite development	J:94943
	abnormal umbilical cord morphology	J:94943
	abnormal visceral yolk sac morphology	J:94943
	abnormal vitelline vasculature morphology	J:94943
	absent intersomitic vessels	J:94943
	decreased embryo size	J:94943
	delayed heart development	J:94943
	distended pericardium	J:94943
	embryonic lethality during organogenesis, complete penetrance	J:94943
	failure of vascular branching	J:94943
	small first pharyngeal arch	J:94943
Adam10^tm1Zhu/Adam10^tm1.1Zhu Tg(Lck-cre)#Zhu/0 involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J	abnormal T cell differentiation	J:139042
	decreased CD4-positive, alpha-beta T cell number	J:139042
	decreased double-positive T cell number	J:139042
	thymus hypoplasia	J:139042
Adam10^tm1Zhu/Adam10^tm1Zhu Tg(Lck-cre)#Zhu/0 involves: 129S6/SvEvTac * C57BL/6 * SJL/J	abnormal T cell differentiation	J:139042
	decreased CD4-positive, alpha-beta T cell number	J:139042
	decreased double-positive T cell number	J:139042
	thymus hypoplasia	J:139042
Adam10^tm2Psa/Adam10^tm2Psa involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:159624
Adam10^tm2Psa/Adam10^tm2Psa Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal embryonic neuroepithelial layer differentiation	J:159624
	abnormal embryonic/fetal subventricular zone morphology	J:159624
	intracranial hemorrhage	J:159624
	perinatal lethality, incomplete penetrance	J:159624
Adam10^tm2Psa/Adam10^tm2Psa Tg(Serpinb7-icre)1Fech/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	normal digestive/alimentary phenotype	J:191899
	forestomach hypoplasia	J:191899
Adam10^tm2Psa/Adam10^tm2Psa Tg(Tek-cre)1Ywa/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal blood vessel morphology	J:307517
	abnormal decidualization	J:307517
	abnormal embryo implantation	J:307517
	abnormal embryo invasion	J:307517
	abnormal luminal closure	J:307517
	abnormal pregnancy	J:307517
	decreased litter size	J:307517
	female infertility	J:307517
	impaired embryo implantation	J:307517
	increased vascular endothelial cell number	J:307517
	reduced female fertility	J:307517

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