Adam10 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adam10
a disintegrin and metallopeptidase domain 10
MGI:109548

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adam10^Pied/Adam10⁺ Hr^hr/Hr⁺ HRA/SkhKcl-Adam10^Pied Hr^Hr	normal pigmentation phenotype	J:262499
Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr HRA/SkhKcl-Adam10^Pied Hr^Hr	abnormal skin pigmentation	J:262499
	hairless	J:262499
Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(Dct-lacZ)A12Jkn/0 involves: C3HeB/FeJ * C57BL/6 * CBA * HRA/SkhKcl	abnormal melanocyte morphology	J:262499
	hairless	J:262499
	increased melanocyte number	J:262499
Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(KRT14-Kitl)4XTG2Bjl/0 involves: C57BL/6J HRA/SkhKcl * SJL	abnormal skin pigmentation	J:262499
	hairless	J:262499
Adam10^Pied/Adam10⁺ Cd44^tm1Hbg/Cd44^tm1Hbg Hr^hr/Hr^hr involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl	abnormal skin pigmentation	J:262499
	hairless	J:262499
Adam10^Pied/Adam10^Pied Hr^hr/Hr^hr involves: CAST/EiJ * HRA/SkhKcl	abnormal heart looping	J:262499
	abnormal neural tube morphology	J:262499
	abnormal somite border morphology	J:262499
	caudal body truncation	J:262499
	decreased embryo size	J:262499
	enlarged pericardium	J:262499
	preweaning lethality, complete penetrance	J:262499
	small pharyngeal arch	J:262499
	telencephalon hypoplasia	J:262499
Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl	abnormal heart looping	J:262499
	abnormal neural tube morphology	J:262499
	abnormal somite border morphology	J:262499
	caudal body truncation	J:262499
	decreased embryo size	J:262499
	enlarged pericardium	J:262499
	small pharyngeal arch	J:262499
	telencephalon hypoplasia	J:262499
Adam10^tm1.1Khr/Adam10^tm1.1Khr Csf3r^tm1Link/Csf3r^tm1Link Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N	abnormal granulocyte differentiation	J:179060
	enlarged spleen	J:179060
	myeloid hyperplasia	J:179060
	spleen hyperplasia	J:179060
Adam10^tm1Beni/Adam10^tm1Beni Adam17^tm1.1Srj/Adam17^tm1.1Srj Tg(Pf4-icre)Q3Rsko/0 involves: 129/Sv * 129S/SvEv * C57BL/6	abnormal platelet physiology	J:165863
	preweaning lethality, incomplete penetrance	J:165863
Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh	abnormal skin pigmentation	J:262499
	hairless	J:262499

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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