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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Terc
telomerase RNA component
MGI:109558
72 phenotypes from 1 allele in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Terctm1Rdp/Terctm1Rdp
B6J.Cg-Terctm1Rdp 		abnormal adipose tissue distribution J:213181
abnormal bone marrow morphology J:213181
abnormal bone ossification J:213181
abnormal compact bone morphology J:213181
abnormal osteoid morphology J:213181
abnormal skeleton physiology J:213181
decreased bone trabecula number J:213181
decreased bone volume J:213181
decreased compact bone area J:213181
decreased compact bone thickness J:213181
decreased trabecular bone thickness J:213181
increased bone trabecular spacing J:213181
osteoporosis J:213181
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal cell physiology J:125218
abnormal DNA repair J:125218
abnormal enterocyte proliferation J:125218
abnormal intestine morphology J:125218
chromosomal instability J:125218
decreased telomere length J:125218
increased enterocyte apoptosis J:125218
increased lymphoma incidence J:125218
premature death J:125218
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * C57BL/6J * SJL 		abnormal angiogenesis J:74001
abnormal cardiac muscle contractility J:110900
abnormal cardiac muscle relaxation J:110900
abnormal cardiovascular system physiology J:110900
abnormal chromosome morphology J:89751
abnormal developmental patterning J:53600
abnormal female meiosis J:89751
abnormal fetal cardiomyocyte proliferation J:110900
abnormal intestine morphology J:120065
abnormal male meiosis J:89751
abnormal meiosis J:89751
abnormal myocardial fiber morphology J:110900
abnormal oocyte morphology J:89751
abnormal spermatocyte morphology J:89751
abnormal telomere length J:43517, J:60223, J:74001, J:89751, J:96945, J:110900, J:120065
alopecia J:120065
cardiac hypertrophy J:110900
congestive heart failure J:110900
decreased B cell proliferation J:60223
decreased body size J:120065
decreased body weight J:120065
decreased fetal size J:89751
decreased heart left ventricle weight J:110900
decreased heart weight J:110900
decreased incidence of induced tumors J:74001
decreased incidence of tumors by chemical induction J:96945
decreased left ventricle developed pressure J:110900
decreased litter size J:53600
decreased locomotor activity J:110900
decreased myocardial fiber number J:110900
decreased spleen B cell follicle number J:60223
decreased spleen germinal center number J:60223
decreased T cell proliferation J:60223
dilated cardiomyopathy J:110900
heart left ventricle hypertrophy J:110900
normal homeostasis/metabolism phenotype J:96945
increased apoptosis J:120065
increased B cell apoptosis J:60223
increased cardiomyocyte apoptosis J:110900
increased embryonic tissue cell apoptosis J:53600
increased left ventricle diastolic pressure J:110900
increased male germ cell apoptosis J:89751, J:120065
infertility J:53600
kyphosis J:120065
open neural tube J:53600
premature aging J:120065
premature death J:110900
prenatal lethality, incomplete penetrance J:53600, J:89751
reduced female fertility J:89751
testicular atrophy J:120065
weight loss J:110900
Terctm1Rdp/Terctm1Rdp
involves: FVB/N 		abnormal spermatid morphology J:98586
abnormal telomere length J:98586
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory