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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Terc
telomerase RNA component
MGI:109558
105 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn2atm1Rdp/Cdkn2a+
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * C57BL/6J * SJL 		increased lymphoma incidence J:120065
increased sarcoma incidence J:120065
increased tumor incidence J:120065
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * C57BL/6J * SJL 		abnormal intestine morphology J:120065
abnormal telomere length J:120065
decreased body size J:120065
decreased body weight J:120065
decreased cell proliferation J:120065
increased lymphoma incidence J:120065
increased male germ cell apoptosis J:120065
increased sarcoma incidence J:120065
increased tumor incidence J:120065
kyphosis J:120065
premature aging J:120065
testicular atrophy J:120065
Dmdmdx-4Cv/Dmdmdx-4Cv
Terctm1Rdp/Terctm1Rdp
B6.Cg-Terctm1Rdp Dmdmdx-4Cv 		abnormal mitochondrial shape J:200365
abnormal myocardial fiber morphology J:200365
cardiac fibrosis J:200365
decreased heart ventricle muscle contractility J:200365
decreased mitochondrial size J:200365
decreased telomere length J:200365
dilated cardiomyopathy J:200365
dilated heart left ventricle J:200365
disorganized mitochondrial cristae J:200365
increased heart left ventricle size J:200365
increased mitochondrial number J:200365
oxidative stress J:200365
premature death J:200365
prolonged QRS complex duration J:200365
ventricular cardiomyopathy J:200365
Dmdmdx/Y
Terctm1Rdp/Terc+
involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL 		abnormal diaphragm morphology J:167294
abnormal muscle physiology J:167294
centrally nucleated skeletal muscle fibers J:167294
increased circulating creatine kinase level J:167294
Dmdmdx/Y
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL 		abnormal diaphragm morphology J:167294
abnormal muscle electrophysiology J:167294
abnormal muscle physiology J:167294
abnormal skeletal muscle morphology J:167294
calcified muscle J:167294
centrally nucleated skeletal muscle fibers J:167294
chromosomal instability J:167294
decreased satellite cell number J:167294
decreased telomere length J:167294
dystrophic muscle J:167294
impaired exercise endurance J:167294
increased circulating creatine kinase level J:167294
increased variability of skeletal muscle fiber size J:167294
kyphosis J:167294
muscle weakness J:167294
muscular atrophy J:167294
myositis J:167294
premature death J:167294
respiratory failure J:167294
skeletal muscle degeneration J:167294
skeletal muscle fibrosis J:167294
skeletal muscle necrosis J:167294
Pms2tm1Lisk/Pms2tm1Lisk
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL 		abnormal cell physiology J:125218
abnormal DNA repair J:125218
abnormal intestine morphology J:125218
chromosomal instability J:125218
decreased telomere length J:125218
normal digestive/alimentary phenotype J:125218
increased carcinoma incidence J:125218
increased enterocyte apoptosis J:125218
increased lymphoma incidence J:125218
increased sarcoma incidence J:125218
normal mortality/aging J:125218
Pot1btm1.1Schg/Pot1btm1.1Schg
Terctm1Rdp/Terc+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal blood cell morphology/development J:144553
abnormal crypts of Lieberkuhn morphology J:144553
abnormal definitive hematopoiesis J:144553
abnormal granulocyte morphology J:144553
abnormal nail morphology J:144553
abnormal spermatogenesis J:144553
absent bone marrow cell J:144553
anemia J:144553
decreased body weight J:144553
decreased erythrocyte cell number J:144553
decreased granulocyte number J:144553
decreased hematopoietic stem cell number J:144553
decreased leukocyte cell number J:144553
decreased male germ cell number J:144553
hyperpigmentation J:144553
impaired hematopoiesis J:144553
increased apoptosis J:144553
premature death J:144553
small testis J:144553
thrombocytopenia J:144553
Pot1btm1.1Schg/Pot1btm1.1Schg
Terctm1Rdp/Terctm1Rdp
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal erythrocyte morphology J:144553
abnormal granulocyte morphology J:144553
abnormal intestine morphology J:144553
abnormal spermatogenesis J:144553
absent bone marrow cell J:144553
decreased male germ cell number J:144553
pancytopenia J:144553
postnatal lethality, complete penetrance J:144553
Terctm1Rdp/Terctm1Rdp
Terf1tm1Tdl/Terf1tm1Tdl
involves: 129S2/SvPas 		prenatal lethality, complete penetrance J:85440
Terctm1Rdp/Terctm1Rdp
Tg(KRT5-Terf2)PMBlas/Y
involves: 129/Sv * C57BL/6 * CBA * SJL 		decreased telomere length J:102653
dry skin J:102653
focal hair loss J:102653
Terctm1Rdp/Terctm1Rdp
Tg(KRT5-Tert)8043Blas/0
involves: 129/Sv * C57BL/6 * C57BL/6J * DBA/2 * SJL 		abnormal chromosome morphology J:96945
decreased incidence of tumors by chemical induction J:96945
decreased telomere length J:96945
delayed wound healing J:96945
Terctm1Rdp/Terctm1Rdp
Tinf2tm2.2Tdl/Tinf2+
involves: 129 * BALB/cJ * C57BL/6 * SJL 		abnormal chromosome morphology J:207367
decreased telomere length J:207367
Terctm1Rdp/Terctm1Rdp
Wrntm1Lgu/Wrntm1Lgu
involves: 129/Sv * BALB/c * C57BL/6 * SLJ 		abnormal adipose tissue distribution J:213181
abnormal bone marrow morphology J:213181
abnormal bone ossification J:213181
abnormal bone trabecula morphology J:213181
abnormal chromosome morphology J:91715
abnormal compact bone morphology J:213181
abnormal crypts of Lieberkuhn morphology J:91715
abnormal femur morphology J:91715
abnormal osteoid morphology J:213181
abnormal skeleton physiology J:213181
alopecia J:91715
cataract J:91715
decreased body weight J:91715
decreased bone trabecula number J:213181
decreased bone volume J:213181
decreased compact bone area J:213181
decreased compact bone thickness J:91715, J:213181
decreased subcutaneous adipose tissue amount J:91715
decreased telomere length J:91715
decreased trabecular bone mass J:91715
decreased trabecular bone thickness J:213181
delayed wound healing J:91715
fragile skeleton J:91715
hyperglycemia J:91715
impaired glucose tolerance J:91715
impaired wound healing J:91715
increased bone trabecular spacing J:213181
increased circulating insulin level J:91715
increased osteosarcoma incidence J:91715
increased sarcoma incidence J:91715
kyphosis J:91715
osteoporosis J:91715, J:213181
premature aging J:91715
premature death J:91715
small gonad J:91715
small testis J:91715
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory