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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cxcr4
C-X-C motif chemokine receptor 4
MGI:109563
146 phenotypes from 10 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Cxcr4tm1Tng/Cxcr4tm2Tng
involves: 129P2/OlaHsd * C57BL/6 		decreased plasma cell number J:109147
Cxcr4b2b220Clo/Cxcr4b2b220Clo
C57BL/6J-Cxcr4b2b220Clo 		aorta stenosis J:175213
aortic arch hypoplasia J:175213
aortic valve atresia J:175213
double aortic arch J:175213
duplex kidney J:175213
hydronephrosis J:175213
muscular ventricular septal defect J:175213
perimembraneous ventricular septal defect J:175213
polycystic kidney J:175213
right aortic arch J:175213
Cxcr4em1(IMPC)Mbp/Cxcr4+
C57BL/6NCrl-Cxcr4em1(IMPC)Mbp/MbpMmucd 		abnormal eyelid morphology J:211773
abnormal kidney morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta size J:211773
abnormal skin morphology J:211773
abnormal testis morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
decreased circulating creatinine level J:211773
embryonic growth retardation J:211773
enlarged kidney J:211773
enlarged testis J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased monocyte cell number J:211773
microphthalmia J:211773
persistence of hyaloid vascular system J:211773
Cxcr4em1(IMPC)Mbp/Cxcr4em1(IMPC)Mbp
C57BL/6NCrl-Cxcr4em1(IMPC)Mbp/MbpMmucd 		abnormal blood vessel morphology J:211773
abnormal limb morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta size J:211773
edema J:211773
embryonic growth retardation J:211773
preweaning lethality, complete penetrance J:211773
Cxcr4tm1.1Bala/Cxcr4+
B6.129S2-Cxcr4tm1.1Bala 		abnormal CD4-positive, alpha-beta T cell number J:186735
abnormal cell chemotaxis J:186735
abnormal immune system cell morphology J:186735
abnormal immune system morphology J:186735
abnormal immune system organ morphology J:186735
abnormal immune system physiology J:186735
abnormal lymph node B cell domain morphology J:186735
abnormal lymph node morphology J:186735
abnormal neutrophil morphology J:186735
abnormal NK cell physiology J:178789
abnormal spleen morphology J:186735
abnormal spleen white pulp morphology J:186735
abnormal thymus morphology J:186735
decreased B cell apoptosis J:186735
decreased B cell number J:186735
decreased immature B cell number J:186735
decreased leukocyte cell number J:186735
decreased NK cell number J:178789
decreased spleen weight J:186735
decreased T cell number J:186735
increased IgG level J:186735
increased IgM level J:186735
increased immunoglobulin level J:186735
increased mature B cell number J:186735
increased NK cell number J:178789
Cxcr4tm1Qma/Cxcr4tm1Qma
B6.129X-Cxcr4tm1Qma/J 		abnormal muscle precursor cell migration J:100909
abnormal myogenesis J:100909
Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ 		abnormal cerebellum morphology J:49070
absent cerebellar foliation J:49070
atelectasis J:49070
decreased body size J:49070
decreased bone marrow cell number J:49070
decreased pro-B cell number J:49070
ectopic Purkinje cell J:49070
impaired myelopoiesis J:49070
kidney hemorrhage J:49070
kidney vascular congestion J:49070
perinatal lethality, incomplete penetrance J:49070
thin external granule cell layer J:49070
Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ * C57BL/6 		abnormal nervous system physiology J:132342
decreased susceptibility to Retroviridae infection J:132342
increased susceptibility to Retroviridae infection induced morbidity/mortality J:132342
Cxcr4tm1Tng/Cxcr4tm1Tng
B6.Cg-Cxcr4tm1Tng 		abnormal primordial germ cell migration J:83291
abnormal T cell differentiation J:82996
decreased double-positive T cell number J:82996
Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd 		abnormal angiogenesis J:69256
abnormal B cell differentiation J:69256
abnormal developmental vascular remodeling J:195048
abnormal heart morphology J:178190
abnormal heart right ventricle outflow tract morphology J:178190
abnormal skin vasculature morphology J:195048
abnormal vascular smooth muscle morphology J:195048
abnormal vasculogenesis J:178190
normal cardiovascular system phenotype J:69256
normal digestive/alimentary phenotype J:69256
normal embryo phenotype J:69256
failure of myelopoiesis J:69256
neonatal lethality, complete penetrance J:69256
normal nervous system phenotype J:195048
perimembraneous ventricular septal defect J:69256
perinatal lethality, incomplete penetrance J:69256
poor arterial differentiation J:195048
small intestine hemorrhage J:69256
thick mitral valve cusps J:178190
ventricular septal defect J:178190
Cxcr4tm1Tng/Cxcr4tm2Tng
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal developmental vascular remodeling J:195048
abnormal skin vasculature morphology J:195048
abnormal vascular smooth muscle morphology J:195048
normal nervous system phenotype J:195048
poor arterial differentiation J:195048
Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd 		abnormal leukocyte migration J:164872
decreased susceptibility to induced arthritis J:164872
decreased thymocyte number J:164872
Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified 		abnormal B cell differentiation J:167314
abnormal B cell physiology J:167314
abnormal cerebellum external granule cell layer morphology J:69255
abnormal cerebellum morphology J:69255
abnormal cerebral cortex morphology J:81783
abnormal dentate gyrus morphology J:79852, J:81783
abnormal interventricular septum morphology J:69255
abnormal leukopoiesis J:69255
abnormal lymphopoiesis J:69255
abnormal primordial germ cell migration J:84597
decreased fetal size J:69255
decreased primordial germ cell number J:84597
hydrops fetalis J:69255
impaired myelopoiesis J:69255
lethality throughout fetal growth and development, incomplete penetrance J:69255
normal nervous system phenotype J:81783
perinatal lethality, complete penetrance J:167314
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:94911
abnormal Peyer's patch follicle morphology J:94911
decreased B-1 B cell number J:94911
decreased B-2 B cell number J:94911
decreased immunoglobulin level J:94911
decreased mature B cell number J:94911
decreased plasma cell number J:94911
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		normal adipose tissue phenotype J:217569
normal growth/size/body region phenotype J:217569
increased lymphocyte cell number J:217569
increased monocyte cell number J:217569
increased neutrophil cell number J:217569
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Tg(Fabp4-cre)1Rev/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal macrophage cell number J:217569
decreased B cell number J:217569
decreased CD4-positive, alpha-beta T cell number J:217569
decreased oxygen consumption J:217569
normal growth/size/body region phenotype J:217569
normal homeostasis/metabolism phenotype J:217569
impaired adaptive thermogenesis J:217569
increased brown adipose tissue mass J:217569
increased brown fat cell size J:217569
increased CD8-positive, alpha-beta T cell number J:217569
increased gonadal fat pad weight J:217569
increased mesenteric fat pad weight J:217569
increased retroperitoneal fat pad weight J:217569
increased subcutaneous adipose tissue amount J:217569
increased susceptibility to diet-induced obesity J:217569
increased total body fat amount J:217569
increased white adipose tissue mass J:217569
increased white fat cell size J:217569
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal heart morphology J:289614
abnormal myocardial fiber morphology J:289614
cardiac hypertrophy J:289614
cardiac interstitial fibrosis J:289614
cardiomyopathy J:289614
congestive heart failure J:289614
decreased heart left ventricle muscle contractility J:289614
decreased heart ventricle muscle contractility J:289614
decreased left ventricle systolic pressure J:289614
increased heart weight J:289614
increased physiological sensitivity to xenobiotic J:289614
perivascular fibrosis J:289614
premature death J:289614
Cxcr4tm2Yzo/Cxcr4tm3.1Yzo
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:167314
Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Not Specified 		abnormal B cell physiology J:167314
abnormal blood vessel morphology J:167314
abnormal cerebellum external granule cell layer morphology J:167314
decreased pro-B cell number J:167314
impaired myelopoiesis J:167314
perinatal lethality, complete penetrance J:167314
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory