About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kmt2b
lysine (K)-specific methyltransferase 2B
MGI:109565
58 phenotypes from 7 alleles in 13 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Kmt2bGena263/Kmt2b+
involves: BALB/c * C3H/HeH 		abnormal hepatocyte morphology J:203736
decreased epididymal fat pad weight J:203736
decreased insulin secretion J:203736
enlarged pancreatic islets J:203736
hepatic steatosis J:203736
impaired glucose tolerance J:203736
increased circulating cholesterol level J:203736
increased circulating glucose level J:79719, J:203736
increased circulating insulin level J:203736
increased circulating triglyceride level J:203736
increased liver free fatty acids level J:203736
increased liver triglyceride level J:203736
increased liver weight J:203736
increased total body fat amount J:203736
insulin resistance J:203736
Kmt2bGena263/Kmt2bGena263
involves: BALB/c * C3H/HeH 		abnormal embryo turning J:203736
abnormal head morphology J:203736
abnormal heart looping J:203736
embryonic growth retardation J:203736
embryonic lethality, incomplete penetrance J:203736
exencephaly J:203736
lethality during fetal growth through weaning, incomplete penetrance J:203736
pericardial effusion J:203736
perinatal lethality, complete penetrance J:203736
rostral body truncation J:203736
Kmt2bGena263/Kmt2btm1Afst
involves: 129P2/OlaHsd * BALB/c * C3H/HeH 		edema J:203736
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:203736
embryonic lethality during organogenesis, complete penetrance J:203736
exencephaly J:203736
pericardial effusion J:203736
Kmt2bm1H/Kmt2b+
involves: BALB/c * C3H/HeH 		decreased epididymal fat pad weight J:203736
decreased insulin secretion J:203736
impaired glucose tolerance J:203736
increased circulating glucose level J:203736
increased circulating insulin level J:203736
increased liver weight J:203736
insulin resistance J:203736
Kmt2btm1.1Afst/Kmt2btm1.1Afst
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:107403
Kmt2btm1.1Afst/Kmt2btm1.1Afst
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129P2/OlaHsd * 129S/Sv * C3H/HeH * C57BL/6 		normal homeostasis/metabolism phenotype J:203736
Kmt2btm1.2Afst/Kmt2btm1.2Afst
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL 		abnormal somite development J:107403
embryonic growth retardation J:107403
embryonic lethality, complete penetrance J:107403
increased apoptosis J:107403
kinked neural tube J:107403
open neural tube J:107403
Kmt2btm1Afst/Kmt2b+
involves: 129P2/OlaHsd 		decreased insulin secretion J:203736
impaired glucose tolerance J:203736
increased circulating glucose level J:203736
increased circulating insulin level J:203736
increased epididymal fat pad weight J:203736
insulin resistance J:203736
normal liver/biliary system phenotype J:203736
Kmt2btm1Afst/Kmt2btm1.1Afst
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		abnormal DNA methylation J:166778
abnormal ovarian follicle number J:166778
decreased primary ovarian follicle number J:166778
decreased primordial ovarian follicle number J:166778
decreased secondary ovarian follicle number J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
reduced female fertility J:166778
Kmt2btm1Afst/Kmt2btm1.1Afst
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		female infertility J:166778
Kmt2btm1Afst/Kmt2btm1.1Afst
Tg(Gdf9-icre)5092Coo/0
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal cell physiology J:166778
abnormal DNA methylation J:166778
abnormal female meiosis I arrest J:166778
abnormal imprinting J:166778
abnormal ovarian follicle number J:166778
decreased circulating estradiol level J:166778
decreased primordial ovarian follicle number J:166778
decreased superovulation rate J:166778
female infertility J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
increased circulating luteinizing hormone level J:166778
increased follicle recruitment J:166778
increased primary ovarian follicle number J:166778
increased secondary ovarian follicle number J:166778
Kmt2btm1Afst/Kmt2btm1.1Afst
Tg(Zp3-cre)3Mrt/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal DNA methylation J:166778
abnormal ovarian follicle number J:166778
decreased primordial ovarian follicle number J:166778
decreased superovulation rate J:166778
embryonic growth arrest J:166778
female infertility J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
Kmt2btm1Afst/Kmt2btm1Afst
involves: 129P2/OlaHsd * C57BL/6 		abnormal somite development J:107403
embryonic growth retardation J:107403
embryonic lethality, complete penetrance J:107403
increased apoptosis J:107403
kinked neural tube J:107403
open neural tube J:107403
Kmt2btm1Jjdh/Kmt2btm1Jjdh
Not Specified 		normal cellular phenotype J:112159
Kmt2btm2.1Afst/Kmt2b+
involves: 129 * C57BL/6 		embryonic growth arrest J:166778
reduced female fertility J:166778
Kmt2btm2.1Afst/Kmt2btm2.1Afst
involves: 129 * C57BL/6 		abnormal DNA methylation J:166778
abnormal embryo development J:166778
embryonic growth arrest J:166778
reduced female fertility J:166778
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory