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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kmt2b
lysine (K)-specific methyltransferase 2B
MGI:109565
58 phenotypes from 7 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kmt2bGena263/Kmt2b+
involves: BALB/c * C3H/HeH 		abnormal hepatocyte morphology J:203736
decreased epididymal fat pad weight J:203736
decreased insulin secretion J:203736
enlarged pancreatic islets J:203736
hepatic steatosis J:203736
impaired glucose tolerance J:203736
increased circulating cholesterol level J:203736
increased circulating glucose level J:79719, J:203736
increased circulating insulin level J:203736
increased circulating triglyceride level J:203736
increased liver free fatty acids level J:203736
increased liver triglyceride level J:203736
increased liver weight J:203736
increased total body fat amount J:203736
insulin resistance J:203736
Kmt2bGena263/Kmt2bGena263
involves: BALB/c * C3H/HeH 		abnormal embryo turning J:203736
abnormal head morphology J:203736
abnormal heart looping J:203736
embryonic growth retardation J:203736
embryonic lethality, incomplete penetrance J:203736
exencephaly J:203736
lethality during fetal growth through weaning, incomplete penetrance J:203736
pericardial effusion J:203736
perinatal lethality, complete penetrance J:203736
rostral body truncation J:203736
Kmt2bGena263/Kmt2btm1Afst
involves: 129P2/OlaHsd * BALB/c * C3H/HeH 		edema J:203736
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:203736
embryonic lethality during organogenesis, complete penetrance J:203736
exencephaly J:203736
pericardial effusion J:203736
Kmt2bm1H/Kmt2b+
involves: BALB/c * C3H/HeH 		decreased epididymal fat pad weight J:203736
decreased insulin secretion J:203736
impaired glucose tolerance J:203736
increased circulating glucose level J:203736
increased circulating insulin level J:203736
increased liver weight J:203736
insulin resistance J:203736
Kmt2btm1.1Afst/Kmt2btm1.1Afst
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:107403
Kmt2btm1.1Afst/Kmt2btm1.1Afst
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129P2/OlaHsd * 129S/Sv * C3H/HeH * C57BL/6 		normal homeostasis/metabolism phenotype J:203736
Kmt2btm1.2Afst/Kmt2btm1.2Afst
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL 		abnormal somite development J:107403
embryonic growth retardation J:107403
embryonic lethality, complete penetrance J:107403
increased apoptosis J:107403
kinked neural tube J:107403
open neural tube J:107403
Kmt2btm1Afst/Kmt2b+
involves: 129P2/OlaHsd 		decreased insulin secretion J:203736
impaired glucose tolerance J:203736
increased circulating glucose level J:203736
increased circulating insulin level J:203736
increased epididymal fat pad weight J:203736
insulin resistance J:203736
normal liver/biliary system phenotype J:203736
Kmt2btm1Afst/Kmt2btm1.1Afst
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		abnormal DNA methylation J:166778
abnormal ovarian follicle number J:166778
decreased primary ovarian follicle number J:166778
decreased primordial ovarian follicle number J:166778
decreased secondary ovarian follicle number J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
reduced female fertility J:166778
Kmt2btm1Afst/Kmt2btm1.1Afst
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		female infertility J:166778
Kmt2btm1Afst/Kmt2btm1.1Afst
Tg(Gdf9-icre)5092Coo/0
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal cell physiology J:166778
abnormal DNA methylation J:166778
abnormal female meiosis I arrest J:166778
abnormal imprinting J:166778
abnormal ovarian follicle number J:166778
decreased circulating estradiol level J:166778
decreased primordial ovarian follicle number J:166778
decreased superovulation rate J:166778
female infertility J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
increased circulating luteinizing hormone level J:166778
increased follicle recruitment J:166778
increased primary ovarian follicle number J:166778
increased secondary ovarian follicle number J:166778
Kmt2btm1Afst/Kmt2btm1.1Afst
Tg(Zp3-cre)3Mrt/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal DNA methylation J:166778
abnormal ovarian follicle number J:166778
decreased primordial ovarian follicle number J:166778
decreased superovulation rate J:166778
embryonic growth arrest J:166778
female infertility J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
Kmt2btm1Afst/Kmt2btm1Afst
involves: 129P2/OlaHsd * C57BL/6 		abnormal somite development J:107403
embryonic growth retardation J:107403
embryonic lethality, complete penetrance J:107403
increased apoptosis J:107403
kinked neural tube J:107403
open neural tube J:107403
Kmt2btm1Jjdh/Kmt2btm1Jjdh
Not Specified 		normal cellular phenotype J:112159
Kmt2btm2.1Afst/Kmt2b+
involves: 129 * C57BL/6 		embryonic growth arrest J:166778
reduced female fertility J:166778
Kmt2btm2.1Afst/Kmt2btm2.1Afst
involves: 129 * C57BL/6 		abnormal DNA methylation J:166778
abnormal embryo development J:166778
embryonic growth arrest J:166778
reduced female fertility J:166778
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory