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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
MGI:109587
75 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tnfrsf11bem1(IMPC)Mbp/Tnfrsf11bem1(IMPC)Mbp
C57BL/6N-Tnfrsf11bem1(IMPC)Mbp/MbpMmucd 		abnormal auditory brainstem response J:211773
abnormal bone structure J:211773
abnormal brain morphology J:211773
abnormal eye morphology J:211773
abnormal gait J:211773
abnormal kidney morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal skin morphology J:211773
abnormal vitreous body morphology J:211773
anophthalmia J:211773
blind uterus J:211773
cornea opacity J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased brain size J:211773
decreased grip strength J:211773
decreased locomotor activity J:211773
enlarged kidney J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating phosphate level J:211773
preweaning lethality, incomplete penetrance J:211773
small spleen J:211773
urinary bladder obstruction J:211773
Tnfrsf11btm1Eac/Tnfrsf11btm1Eac
involves: 129S4/SvJaeSor 		abnormal bone structure J:67105
abnormal compact bone morphology J:67105
abnormal dendritic cell antigen presentation J:67105
abnormal immune system morphology J:67105
abnormal immune system physiology J:67105
abnormal immunoglobulin level J:67105
abnormal long bone morphology J:67105
abnormal mandible morphology J:67105
abnormal pro-B cell differentiation J:67105
decreased bone mineral density J:67105
increased B cell number J:67105
increased diameter of long bones J:67105
increased immature B cell number J:67105
increased pro-B cell number J:67105
short femur neck J:67105
Tnfrsf11btm1Khs/Tnfrsf11btm1Khs
B6.129P2-Tnfrsf11btm1Khs 		abnormal bone remodeling J:117756
abnormal inner ear morphology J:117756
abnormal malleus morphology J:117756
abnormal middle ear morphology J:117756
abnormal otic capsule morphology J:117756
abnormal stapes footplate morphology J:117756
absent distortion product otoacoustic emissions J:117756
deafness J:117756
increased or absent distortion product otoacoustic emission threshold J:117756
increased or absent threshold for auditory brainstem response J:117756
increased susceptibility to age-related hearing loss J:117756
osteoporosis J:117756
otosclerosis J:117756
Tnfrsf11btm1Khs/Tnfrsf11btm1Khs
involves: 129P2/OlaHsd * C57BL/6 		abnormal bone structure J:111153
abnormal incus body morphology J:111153
abnormal inner ear morphology J:111153
abnormal long bone epiphyseal plate morphology J:48325
abnormal malleus morphology J:111153
abnormal middle ear morphology J:111153
abnormal middle ear ossicle morphology J:111153
abnormal osteoclast differentiation J:48325, J:111153
abnormal osteoclast physiology J:111153
abnormal skeleton development J:111153
abnormal skeleton physiology J:111153
abnormal stapes annular ligament morphology J:111153
abnormal stapes footplate morphology J:111153
abnormal stapes morphology J:111153
abnormal trabecular bone morphology J:48325
decreased bone mineral density J:48325, J:111153
fragile skeleton J:48325
increased or absent threshold for auditory brainstem response J:111153
increased osteoclast cell number J:80503
osteoporosis J:48325
postnatal growth retardation J:48325
postnatal lethality, incomplete penetrance J:48325
Tnfrsf11btm1Wss/Tnfrsf11b+
either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss) 		decreased bone mineral density J:47602
Tnfrsf11btm1Wss/Tnfrsf11btm1Wss
either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss) 		abnormal compact bone morphology J:47602
abnormal long bone epiphysis morphology J:47602
abnormal osteoblast morphology J:47602
abnormal osteoclast morphology J:47602
abnormal parietal bone morphology J:47602
absent bone trabeculae J:47602
calcified artery J:47602
decreased body size J:47602
decreased bone mineral density J:47602
decreased trabecular bone mass J:47602
fragile skeleton J:47602
osteoporosis J:47602
postnatal lethality, incomplete penetrance J:47602
thin parietal bone J:47602
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory