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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dsp
desmoplakin
MGI:109611
68 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dspem1(IMPC)Mbp/Dsp+
C57BL/6N-Dspem1(IMPC)Mbp/MbpMmucd 		abnormal embryo turning J:211773
abnormal lymph node morphology J:211773
abnormal neural tube closure J:211773
abnormal neural tube morphology J:211773
abnormal placenta morphology J:211773
enlarged lymph nodes J:211773
Dspem1(IMPC)Mbp/Dspem1(IMPC)Mbp
C57BL/6N-Dspem1(IMPC)Mbp/MbpMmucd 		abnormal embryo turning J:211773
abnormal heart morphology J:211773
abnormal midbrain development J:211773
abnormal neural tube morphology J:211773
abnormal pharyngeal arch morphology J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
Dspem1Melr/Dsp+
C57BL/6-Dspem1Melr 		normal cardiovascular system phenotype J:330171
increased response of heart to induced stress J:330171
Dspem1Melr/Dspem1Melr
C57BL/6-Dspem1Melr 		embryonic lethality during organogenesis, complete penetrance J:330171
Dsprul/Dsp+
RB156Bnr/Ei-Dsprul/GrsrJ 		abnormal heart echocardiography feature J:217650
decreased heart rate J:217650
Dsprul/Dsprul
RB156Bnr/Ei-Dsprul/GrsrJ 		abnormal hair medulla J:217650
abnormal hair medullary septa cells J:217650
abnormal hair shaft morphology J:217650
abnormal hair texture J:217650
abnormal heart apex morphology J:217650
abnormal heart electrocardiography waveform feature J:217650
abnormal heart left ventricle morphology J:217650
abnormal R wave J:217650
abnormal T wave J:217650
abnormal vibrissa follicle morphology J:217650
acanthosis J:217650
cardiac fibrosis J:217650
decreased heart rate J:217650
dermal-epidermal separation J:217650
disheveled coat J:217650
oral mucosa blisters J:217650
prolonged QRS complex duration J:217650
prolonged RR interval J:217650
ruffled hair J:96444, J:217650
sparse hair J:217650
Dsptm1Efu/Dsptm1Efu
Mnx1tm4(cre)Tmj/Mnx1+
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		abnormal sciatic nerve morphology J:219630
decreased nerve conduction velocity J:219630
delayed axon extension J:219630
delayed peripheral nervous system regeneration J:219630
impaired ability to fire action potentials J:219630
Dsptm1Efu/Dsptm1Efu
Myl2tm1(cre)Krc/Myl2+
involves: 129 * 129S4/SvJae * C57BL/6 		abnormal heart morphology J:205990
abnormal impulse conducting system conduction J:205990
abnormal intercalated disk morphology J:205990
abnormal myocardial fiber morphology J:205990
abnormal myocardium layer morphology J:205990
abnormal subendocardium layer morphology J:205990
abnormal Z line morphology J:205990
bundle branch block J:205990
cardiac fibrosis J:205990
decreased heart ventricle muscle contractility J:205990
dilated heart ventricle J:205990
enlarged heart J:205990
increased apoptosis J:205990
increased heart atrium size J:205990
increased susceptibility to induced morbidity/mortality J:205990
irregular heartbeat J:205990
premature death J:205990
prolonged QRS complex duration J:205990
ventricular cardiomyopathy J:205990
ventricular premature beat J:205990
Dsptm1Efu/Dsptm1Efu
Tg(KRT14-cre)1Efu/0
involves: 129 		abnormal cell adhesion J:67797
abnormal corneocyte envelope morphology J:73084
abnormal epidermal layer morphology J:67797, J:73084
abnormal epidermis stratum basale morphology J:73084
abnormal epidermis stratum spinosum morphology J:73084
Dsptm2Efu/Dsptm2Efu
involves: 129S1/Sv * 129X1/SvJ 		abnormal ectoderm development J:51903
abnormal egg cylinder morphology J:51903
abnormal embryonic tissue morphology J:51903
abnormal endoderm development J:51903
decreased embryo size J:51903
embryonic lethality between implantation and somite formation, complete penetrance J:51903
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory