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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tafazzin
tafazzin, phospholipid-lysophospholipid transacylase
MGI:109626
34 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal heart left ventricle morphology J:167527
abnormal myocardial fiber morphology J:167527
abnormal sarcomere morphology J:167527
abnormal skeletal muscle fiber morphology J:167527
decreased body weight J:167527
decreased cardiac muscle contractility J:167527
dilated heart left ventricle J:167527
increased mitochondrial fission J:167527
increased mitochondrial number J:167527
Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte/?
Not Specified 		abnormal mitochondrial morphology J:176041
abnormal mitochondrial physiology J:176041
decreased heart left ventricle muscle contractility J:176041
impaired skeletal muscle contractility J:176041
Tafazzinem1Xfa/Tafazzinem1Xfa
Tg(myl7.L-cre)1118Tmhn/0
involves: C57BL/6NCrl * MF1 		abnormal heart echocardiography feature J:339058
decreased heart left ventricle muscle contractility J:339058
dilated cardiomyopathy J:339058
Tafazzinem1Xfa/Y
Tg(myl7.L-cre)1118Tmhn/0
involves: C57BL/6NCrl * MF1 		abnormal cellular respiration J:339058
abnormal heart echocardiography feature J:339058
abnormal heart left ventricle morphology J:339058
abnormal heart morphology J:339058
abnormal mitochondrial physiology J:339058
abnormal mitochondrial shape J:339058
abnormal phospholipid level J:339058
abnormal respiratory electron transport chain J:339058
decreased heart left ventricle muscle contractility J:339058
decreased mitochondrial size J:339058
decreased survivor rate J:339058
dilated cardiomyopathy J:339058
dilated heart left ventricle J:339058
disorganized mitochondrial cristae J:339058
enlarged heart J:339058
globular heart J:339058
increased mitochondrial number J:339058
premature death J:339058
Tafazzintm1Dost/Y
involves: 129P2/OlaHsd 		abnormal male meiosis J:238324
abnormal seminiferous tubule morphology J:238324
abnormal spermatocyte morphology J:238324
abnormal testis morphology J:238324
azoospermia J:238324
normal cardiovascular system phenotype J:238324
male infertility J:238324
small testis J:238324
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory