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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bad
BCL2-associated agonist of cell death
MGI:1096330
33 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Badtm1Meg/Badtm1Meg
involves: 129S4/SvJae 		abnormal apoptosis J:88139
abnormal B cell differentiation J:88139
abnormal body weight J:133563
abnormal T cell differentiation J:88139
decreased circulating insulin level J:133563
decreased insulin secretion J:133563
decreased mature B cell number J:88139
decreased pro-B cell number J:88139
decreased thymus weight J:88139
increased circulating glucose level J:133563
increased pancreatic beta cell apoptosis J:133563
small pancreatic islets J:133563
small thymus J:88139
thymus hypoplasia J:88139
Badtm1Sjk/Badtm1Sjk
B6.129X1-Badtm1Sjk 		abnormal hippocampus morphology J:111236
gliosis J:111236
Badtm1Sjk/Badtm1Sjk
either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6) 		abnormal apoptosis J:84987
abnormal B cell physiology J:84987
abnormal immune system cell morphology J:84987
abnormal reproductive system morphology J:84987
abnormal T cell physiology J:84987
abnormal testis morphology J:84987
increased B cell derived lymphoma incidence J:84987
increased cellular sensitivity to gamma-irradiation J:84987
increased lymphoma incidence J:84987
increased tumor incidence J:84987
multinucleated giant male germ cells J:84987
premature death J:84987
Badtm1Sjk/Badtm1Sjk
involves: 129X1/SvJ 		abnormal circulating glucose level J:133563
abnormal pancreatic beta cell physiology J:133563
decreased insulin secretion J:133563
normal immune system phenotype J:132819
increased circulating insulin level J:133563
increased pancreatic islet number J:133563
Badtm2Meg/Badtm2Meg
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased insulin secretion J:133563
impaired glucose tolerance J:133563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory