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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335
182 phenotypes from 15 alleles in 26 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adam17m1Btlr/Adam17m1Btlr
C57BL/6J-Adam17m1Btlr 		decreased circulating tumor necrosis factor level J:166602
decreased survivor rate J:166602
decreased transforming growth factor beta level J:166602
increased susceptibility to induced colitis J:166602
waved hair J:166602
weight loss J:166602
Adam17tm1.1Bbl/Adam17tm1.1Bbl
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		enlarged aortic valve J:221411
eyelids open at birth J:221411
failure of eyelid fusion J:221411
increased width of hypertrophic chondrocyte zone J:221411
perinatal lethality J:221411
thick aortic valve cusps J:221411
thick pulmonary valve cusps J:221411
thick tricuspid valve cusps J:221411
Adam17tm1.1Bbl/Adam17tm1.1Bbl
involves: 129P2/OlaHsd * FVB/N 		abnormal aortic valve morphology J:139846
abnormal pulmonary valve morphology J:139846
abnormal tricuspid valve morphology J:139846
eyelids open at birth J:139846
postnatal lethality, complete penetrance J:139846
Adam17tm1.1Rain/Adam17tm1.2Rain
Tg(Tek-cre)12Flv/0
B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv 		abnormal aortic valve cusp morphology J:195050
abnormal aortic valve flow J:195050
abnormal semilunar valve morphology J:195050
aortic valve stenosis J:195050
decreased cardiac muscle contractility J:195050
enlarged semilunar valve J:195050
increased heart left ventricle size J:195050
increased heart left ventricle weight J:195050
increased heart rate J:195050
increased heart weight J:195050
postnatal lethality, incomplete penetrance J:195050
thick aortic valve cusps J:195050
Adam17tm1.1Srj/Adam17tm1.1Srj
involves: 129S/SvEv 		abnormal platelet physiology J:165863
Adam17tm1.1Srj/Adam17tm1.1Srj
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal chemokine level J:163380
abnormal enterocyte proliferation J:163380
abnormal interleukin secretion J:163380
abnormal mammary gland duct morphology J:163380
abnormal mitral valve cusp morphology J:163380
normal digestive/alimentary phenotype J:163380
distorted hair follicle pattern J:163380
eye opacity J:163380
eyelids open at birth J:163380
increased heart left ventricle size J:163380
increased interleukin-10 secretion J:163380
increased susceptibility to induced colitis J:163380
increased susceptibility to induced morbidity/mortality J:163380
increased susceptibility to weight loss J:163380
postnatal lethality, incomplete penetrance J:163380
skin inflammation J:163380
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal myocardial trabeculae morphology J:210193
abnormal myocardium layer morphology J:210193
enlarged heart J:210193
normal mortality/aging J:210193
thin myocardium J:210193
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 * FVB/N 		abnormal lung epithelium morphology J:210193
abnormal lung saccule morphology J:210193
abnormal lung vasculature morphology J:210193
decreased cell proliferation J:210193
normal mortality/aging J:210193
thick lung-associated mesenchyme J:210193
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 * FVB/N 		abnormal lung saccule morphology J:210193
abnormal lung vasculature morphology J:210193
decreased cell proliferation J:210193
normal mortality/aging J:210193
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 * FVB/N 		normal respiratory system phenotype J:210193
Adam17tm1.2Bbl/Adam17tm1.2Bbl
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:139846
Adam17tm1.2Bbl/Adam17tm1.2Bbl
Sox9tm3(cre)Crm/Sox9+
B6.129(SJL)-Sox9tm3(cre)Crm Adam17tm1.2Bbl 		abnormal circulating chemokine level J:229771
abnormal epidermal layer morphology J:229771
abnormal skin morphology J:229771
dermatitis J:229771
dry skin J:229771
impaired skin barrier function J:229771
increased IgE level J:229771
increased pruritus J:229771
increased T-helper 1 cell number J:229771
increased T-helper 2 cell number J:229771
increased T-helper 17 cell number J:229771
Adam17tm1.2Bbl/Adam17tm1.2Bbl
Sox9tm3(cre)Crm/Sox9+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow cavity morphology J:144795
abnormal bone remodeling J:144795
abnormal hair growth J:144795
abnormal long bone epiphyseal plate proliferative zone J:144795
abnormal long bone hypertrophic chondrocyte zone J:144795
abnormal skin condition J:144795
abnormal spleen morphology J:144795
decreased B cell number J:144795
decreased body weight J:144795
decreased bone mass J:144795
decreased compact bone thickness J:144795
decreased hematocrit J:144795
decreased length of long bones J:144795
decreased lymphocyte cell number J:144795
decreased T cell number J:144795
decreased trabecular bone thickness J:144795
early eyelid opening J:144795
enlarged spleen J:144795
extramedullary hematopoiesis J:144795
female infertility J:144795
increased bone marrow cell number J:144795
increased circulating interleukin-17 level J:144795
increased hemoglobin content J:144795
increased interleukin-17 secretion J:144795
increased leukocyte cell number J:144795
increased macrophage cell number J:144795
increased neutrophil cell number J:144795
increased spleen red pulp amount J:144795
osteoporosis J:144795
postnatal growth retardation J:144795
premature death J:144795
reduced male fertility J:144795
short femur J:144795
thrombocytosis J:144795
Adam17tm1.2Rain/Adam17tm1.2Rain
C57BL/6-Adam17tm1.2Rain 		abnormal atrioventricular valve morphology J:195050
enlarged semilunar valve J:195050
increased heart weight J:195050
perinatal lethality, complete penetrance J:195050
Adam17tm1.2Wesh/Adam17tm1.2Wesh
involves: 129 * BALB/cJ * C57BL/6 * FVB/N 		eyelids open at birth J:210193
increased heart ventricle size J:210193
neonatal lethality, incomplete penetrance J:210193
pulmonary hypoplasia J:210193
Adam17tm1a(EUCOMM)Wtsi/Adam17+
B6JTyr;B6N-Adam17tm1a(EUCOMM)Wtsi/Wtsi 		abnormal vibrissa morphology J:175295
increased body weight J:165965
Adam17tm1a(EUCOMM)Wtsi/Adam17+
involves: C57BL/6 * C57BL/6N 		increased bone mineral content J:213427
increased erythrocyte cell number J:213427
lethality, incomplete penetrance J:213427
myeloid hyperplasia J:213427
Adam17tm1Bbl/Adam17tm1Bbl
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:139846
Adam17tm1Bbl/Adam17tm1Bbl
Lyz2tm1(cre)Ifo/0
involves: 129P2/OlaHsd 		abnormal macrophage physiology J:139846
decreased circulating tumor necrosis factor level J:139846
decreased susceptibility to endotoxin shock J:139846
Adam17tm1Bbl/Adam17tm1Bbl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased circulating tumor necrosis factor level J:139846
decreased susceptibility to endotoxin shock J:139846
Adam17tm1Ckww/Adam17tm1Ckww
Not Specified 		abnormal dendritic cell physiology J:138782
normal mortality/aging J:138782
Adam17tm1Imx/Adam17tm1Imx
B6.129-Adam17tm1Imx 		decreased physiological sensitivity to xenobiotic J:174865
enhanced leukocyte tethering or rolling J:174865
Adam17tm1Imx/Adam17tm1Imx
involves: 129 * C57BL/6 		abnormal bronchiole epithelium morphology J:51053
abnormal coat/hair pigmentation J:51053
abnormal conjunctival sac morphology J:51053
abnormal cornea morphology J:51053
abnormal embryonic tissue morphology J:51053
abnormal eye morphology J:51053
abnormal fetal cardiomyocyte proliferation J:85547
abnormal hair follicle morphology J:51053
abnormal hair follicle orientation J:51053
abnormal small intestine morphology J:51053
abnormal trabecula carnea morphology J:85547
abnormal trophoblast layer morphology J:51053
curly vibrissae J:51053
decreased body size J:51053
decreased spongiotrophoblast size J:51053
enlarged heart J:85547
eyelids open at birth J:51053
failure of eyelid fusion J:51053
increased heart weight J:85547
increased incidence of corneal inflammation J:51053
increased myocardial fiber size J:85547
perinatal lethality, incomplete penetrance J:51053
premature death J:51053
short vibrissae J:51053
thick aortic valve J:99649
thick ventricular wall J:85547
ventricular septal defect J:99649
Adam17tm1Imx/Adam17tm1Imx
involves: 129 * C57BL/6J 		abnormal blood vessel morphology J:166217
abnormal brain vasculature morphology J:166217
decreased body length J:166217
decreased fetal weight J:166217
enlarged aortic valve J:83820
enlarged atrioventricular valve J:83820
enlarged pulmonary valve J:83820
enlarged semilunar valve J:83820
internal hemorrhage J:166217
lethality throughout fetal growth and development, incomplete penetrance J:166217
nuchal edema J:166217
Adam17tm1Imx/Adam17tm1Imx
involves: 129 * DBA/1J 		abnormal branching involved in lung morphogenesis J:68672
abnormal lung development J:68672
abnormal lung epithelium morphology J:68672
abnormal lung morphology J:68672
abnormal lung saccule morphology J:68672
abnormal lung vasculature morphology J:68672
abnormal respiratory conducting tube morphology J:68672
cyanosis J:68672
dilated respiratory conducting tube J:68672
eyelids open at birth J:68672
failure of eyelid fusion J:68672
neonatal lethality, complete penetrance J:68672
pale lung J:68672
pulmonary hypoplasia J:68672
respiratory distress J:68672
respiratory failure J:68672
thick lung-associated mesenchyme J:68672
Adam17tm1Imx/Adam17woe
involves: 129 * C57BL/6 		abnormal coat/ hair morphology J:160781
abnormal eye morphology J:160781
eyelids open at birth J:160781
Adam17tm1Rain/Adam17tm1Rain
involves: C57BL/6 		decreased physiological sensitivity to xenobiotic J:174865
enhanced leukocyte tethering or rolling J:174865
Adam17tm1Srj/Adam17tm1Srj
involves: 129S/SvEv * C57BL/6 		premature death J:163380
Adam17woe/Adam17woe
C57BL/6-Adam17woe 		abnormal anterior eye segment morphology J:160781
abnormal canal of Schlemm morphology J:160781
abnormal cornea epithelium morphology J:160781
abnormal cornea morphology J:160781
abnormal eyelid margin morphology J:160781
abnormal hair follicle development J:160781
abnormal heart valve morphology J:160781
abnormal retina morphology J:160781
absent cornea endothelium J:160781
absent Descemet membrane J:160781
absent Meibomian glands J:160781
absent Schlemm's canal J:160781
anophthalmia J:160781
anterior iris synechia J:160781
aortic valve hypertrophy J:160781
aphakia J:160781
cataract J:160781
cornea opacity J:160781
cornea scarring J:160781
decreased cornea thickness J:160781
dermatitis J:160781
normal digestive/alimentary phenotype J:160781
enlarged aortic valve J:160781
enlarged esophagus J:156373
enlarged heart J:156373
enlarged pulmonary valve J:160781
eyelids open at birth J:156373, J:160781
failure of eyelid fusion J:160781
increased incidence of corneal inflammation J:160781
lens vacuoles J:160781
microphthalmia J:160781
pathological neovascularization J:160781
pulmonary valve hypertrophy J:160781
thick aortic valve J:160781
thick pulmonary valve J:160781
waved hair J:156373, J:160781
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory