E2f2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

E2f2
E2F transcription factor 2
MGI:1096341

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
E2f1^tm1Meg/E2f1^tm1Meg E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm2.1Gle/E2f3^tm2.1Gle involves: 129 * FVB/N * NIH Black Swiss	decreased cell proliferation	J:138289
	perinatal lethality	J:138289
E2f1^tm1Meg/E2f1^tm1Meg E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm3.1Gle/E2f3^tm3.1Gle involves: 129 * FVB/N * NIH Black Swiss	decreased body weight	J:138289
	decreased cell proliferation	J:138289
	normal mortality/aging	J:138289
E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm2.1Gle/E2f3^tm2.1Gle involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss	no abnormal phenotype detected	J:138289
E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm3.1Gle/E2f3^tm3.1Gle involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss	no abnormal phenotype detected	J:138289
E2f2^tm1Zubi/E2f2^tm1Zubi Rbl1^tm1Htr/Rbl1^tm1Htr Tg(Pax6-cre,GFP)2Pgr/? involves: 129 * C57BL/6 * FVB/N * NMRI	abnormal eye development	J:124204
	abnormal retina bipolar cell morphology	J:124204
	decreased retina ganglion cell number	J:124204
	decreased retina rod cell number	J:124204
E2f2^tm1Zubi/E2f2^tm1Zubi Tg(TcraH-Y,TcrbH-Y)71Vbo/? involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J	abnormal immune system morphology	J:76318
	abnormal immune system physiology	J:76318
	enlarged spleen	J:76318
	increased CD8-positive, alpha-beta T cell number	J:76318
	increased inflammatory response	J:76318
	increased susceptibility to autoimmune disorder	J:76318
	increased T cell proliferation	J:76318
	premature death	J:76318
	thymus hypoplasia	J:76318

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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