Lhx8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lhx8
LIM homeobox protein 8
MGI:1096343

37 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lhx8^tm1Awan/Lhx8^tm1Awan involves: 129S2/SvPas * C57BL/6J	abnormal cholinergic neuron morphology	J:100340
	cleft palate	J:100340
	neonatal lethality, incomplete penetrance	J:100340
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd involves: 129 * C57BL/6	abnormal double-strand DNA break repair	J:262653
	abnormal mitophagy	J:262653
	decreased oocyte number	J:262653
	enhanced autophagy	J:262653
	increased ovary apoptosis	J:262653
	oocyte degeneration	J:262653
	ovary fibrosis	J:262653
	postnatal lethality, incomplete penetrance	J:262653
	premature ovarian failure	J:262653
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal uterine horn morphology	J:140898
	absent oocytes	J:140898
	absent ovarian follicles	J:140898
	absent primordial ovarian follicles	J:140898
	decreased oocyte number	J:140898
	decreased primordial ovarian follicle number	J:140898
	female infertility	J:140898
	impaired ovarian folliculogenesis	J:140898
	oocyte degeneration	J:140898
	ovary atrophy	J:140898
	normal reproductive system phenotype	J:140898
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cholinergic neuron morphology	J:84641
	abnormal oogenesis	J:294629
	abnormal telencephalon development	J:84641
	cleft secondary palate	J:59082
	normal craniofacial phenotype	J:59082
	neonatal lethality, incomplete penetrance	J:59082
	palatal shelves fail to meet at midline	J:59082
	premature death	J:59082
Lhx8^tm1Vpa/Lhx8^tm1Vpa B6.Cg-Lhx8^tm1Vpa	abnormal cholinergic neuron morphology	J:101205
	abnormal contextual conditioning behavior	J:101205
	abnormal dorsal striatum morphology	J:101205
	abnormal spatial learning	J:101205
	cleft palate	J:101205
	decreased body weight	J:101205
	preweaning lethality, incomplete penetrance	J:101205
Lhx8^tm1Vpa/Lhx8^tm2.1Vpa Tg(Chat-cre)GM24Gsat/0 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N	abnormal brain interneuron morphology	J:182013
	abnormal cholinergic neuron morphology	J:182013
	abnormal GABAergic neuron morphology	J:182013
	abnormal neuron differentiation	J:182013
	abnormal neuron morphology	J:182013
	abnormal striatum morphology	J:182013
Lhx8^tm1Vpa/Lhx8^tm2.1Vpa Tmem163^{Tg(ACTB-cre)2Mrt}/0 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N	abnormal brain interneuron morphology	J:182013
	abnormal striatum morphology	J:182013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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