Lhx8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lhx8
LIM homeobox protein 8
MGI:1096343

37 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lhx8^tm1Awan/Lhx8^tm1Awan involves: 129S2/SvPas * C57BL/6J	abnormal cholinergic neuron morphology	J:100340
	cleft palate	J:100340
	neonatal lethality, incomplete penetrance	J:100340
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd involves: 129 * C57BL/6	abnormal double-strand DNA break repair	J:262653
	abnormal mitophagy	J:262653
	decreased oocyte number	J:262653
	enhanced autophagy	J:262653
	increased ovary apoptosis	J:262653
	oocyte degeneration	J:262653
	ovary fibrosis	J:262653
	postnatal lethality, incomplete penetrance	J:262653
	premature ovarian failure	J:262653
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal uterine horn morphology	J:140898
	absent oocytes	J:140898
	absent ovarian follicles	J:140898
	absent primordial ovarian follicles	J:140898
	decreased oocyte number	J:140898
	decreased primordial ovarian follicle number	J:140898
	female infertility	J:140898
	impaired ovarian folliculogenesis	J:140898
	oocyte degeneration	J:140898
	ovary atrophy	J:140898
	normal reproductive system phenotype	J:140898
Lhx8^tm1Lmgd/Lhx8^tm1Lmgd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cholinergic neuron morphology	J:84641
	abnormal oogenesis	J:294629
	abnormal telencephalon development	J:84641
	cleft secondary palate	J:59082
	normal craniofacial phenotype	J:59082
	neonatal lethality, incomplete penetrance	J:59082
	palatal shelves fail to meet at midline	J:59082
	premature death	J:59082
Lhx8^tm1Vpa/Lhx8^tm1Vpa B6.Cg-Lhx8^tm1Vpa	abnormal cholinergic neuron morphology	J:101205
	abnormal contextual conditioning behavior	J:101205
	abnormal dorsal striatum morphology	J:101205
	abnormal spatial learning	J:101205
	cleft palate	J:101205
	decreased body weight	J:101205
	preweaning lethality, incomplete penetrance	J:101205
Lhx8^tm1Vpa/Lhx8^tm2.1Vpa Tg(Chat-cre)GM24Gsat/0 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N	abnormal brain interneuron morphology	J:182013
	abnormal cholinergic neuron morphology	J:182013
	abnormal GABAergic neuron morphology	J:182013
	abnormal neuron differentiation	J:182013
	abnormal neuron morphology	J:182013
	abnormal striatum morphology	J:182013
Lhx8^tm1Vpa/Lhx8^tm2.1Vpa Tmem163^{Tg(ACTB-cre)2Mrt}/0 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N	abnormal brain interneuron morphology	J:182013
	abnormal striatum morphology	J:182013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/27/2024 MGI 6.24