Wrn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wrn
Werner syndrome RecQ like helicase
MGI:109635

36 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Wrn^b2b3121.1Clo/Wrn^b2b3121.1Clo C57BL/6J-Wrn^b2b3121.1Clo	abnormal cardiovascular development	J:175213
	bicuspid aortic valve	J:175213
	bicuspid pulmonary valve	J:175213
	cleft palate	J:175213
	enlarged adrenal glands	J:175213
	thymus hypoplasia	J:175213
Wrn^{em1(IMPC)Ccpcz}/Wrn^{em1(IMPC)Ccpcz} C57BL/6NCrl-Wrn^{em1(IMPC)Ccpcz}/Ccpcz	abnormal ovary morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	enlarged ovary	J:211773
	increased freezing behavior	J:211773
Wrn^tm1Led/Wrn⁺ involves: 129S6/SvEvTac * Black Swiss	cardiac interstitial fibrosis	J:106446
Wrn^tm1Led/Wrn^tm1Led B6.129S6(BKSW)-Wrn^tm1Led	aortic valve stenosis	J:106446
	cardiac interstitial fibrosis	J:106446
	decreased systemic arterial diastolic blood pressure	J:106446
	hyperglycemia	J:106446
	hyperlipidemia	J:106446
	increased abdominal adipose tissue amount	J:106446
	increased cellular sensitivity to oxidative stress	J:106446
	increased circulating cholesterol level	J:106446
	increased circulating hyaluronic acid level	J:106446
	increased circulating insulin level	J:106446
	increased circulating triglyceride level	J:106446
	increased inguinal fat pad weight	J:106446
	increased left ventricle systolic pressure	J:106446
	increased retroperitoneal fat pad weight	J:106446
	increased susceptibility to age related obesity	J:106446
	insulin resistance	J:106446
	oxidative stress	J:106446
Wrn^tm1Led/Wrn^tm1Led either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * NIH Black Swiss)	increased tumor incidence	J:48424
	preweaning lethality, incomplete penetrance	J:48424
Wrn^tm1Led/Wrn^tm1Led involves: 129S6/SvEvTac * Black Swiss	abnormal thrombosis	J:106446
	cardiac interstitial fibrosis	J:106446
	heart inflammation	J:106446
	increased susceptibility to infection	J:106446
	increased tumor incidence	J:106446
Wrn^tm1Lgu/Wrn^tm1Lgu B6J.Cg-Wrn^tm1Lgu	decreased bone volume	J:213181
Wrn^tm1Lgu/Wrn^tm1Lgu B6J.Cg-Wrn^tm1Lgu	increased osteoclast cell number	J:213181
Wrn^tm1Lgu/Wrn^tm1Lgu involves: BALB/c	abnormal cell physiology	J:61567

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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