S1pr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

S1pr1
sphingosine-1-phosphate receptor 1
MGI:1096355

43 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
S1pr1^tm1.1Cys/S1pr1^tm1.1Cys involves: 129P2/OlaHsd * C3H * C57BL/6	abnormal B cell physiology	J:176118
	decreased B cell number	J:176118
	normal immune system phenotype	J:176118
S1pr1^tm1.1Thla/S1pr1^tm1.1Thla B6.Cg-S1pr1^tm1.1Thla	abnormal leukocyte migration	J:163389
	abnormal lymphocyte physiology	J:163389
	decreased physiological sensitivity to xenobiotic	J:163389
	increased CD4-positive, alpha-beta T cell number	J:163389
	increased CD8-positive, alpha-beta T cell number	J:163389
S1pr1^tm1Cys/S1pr1^tm1Cys involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:176118
	decreased B cell number	J:176118
	normal immune system phenotype	J:176118
S1pr1^tm1Jch/S1pr1^tm1Jch Tg(GFAP-cre)25Mes/? involves: C57BL/6J * FVB/N	abnormal axon morphology	J:168824
	astrocytosis	J:168824
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:168824
	demyelination	J:168824
S1pr1^tm1Jch/S1pr1^tm1Jch Tg(Nes-cre)1Kln/0 involves: C57BL/6J * SJL	abnormal axon morphology	J:168824
	astrocytosis	J:168824
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:168824
	demyelination	J:168824
S1pr1^tm1Jch/S1pr1^tm1Jch Tg(Syn1-cre)671Jxm/? involves: C57BL/6J * CBA	normal immune system phenotype	J:168824
S1pr1^tm1Rlp/S1pr1^tm1Rlp involves: 129S6/SvEvTac	abnormal aorta endothelium morphology	J:189010
	abnormal aorta morphology	J:189010
	abnormal aorta smooth muscle morphology	J:189010
	abnormal artery morphology	J:189010
	abnormal diencephalon morphology	J:103755
	abnormal forebrain morphology	J:103755
	abnormal NK cell differentiation	J:154069
	abnormal telencephalon morphology	J:103755
	abnormal vascular branching morphogenesis	J:189010
	decreased NK cell number	J:154069
	embryonic lethality during organogenesis, complete penetrance	J:189010
	hemorrhage	J:103755
	increased neuron apoptosis	J:189010
	increased vascular endothelial cell apoptosis	J:189010
S1pr1^tm1Rlp/S1pr1^tm1Rlp involves: 129S6/SvEvTac * C57BL/6	abnormal blood vessel morphology	J:71961
	abnormal limb morphology	J:71961, J:106055
	abnormal pericyte morphology	J:71961
	abnormal vascular endothelial cell morphology	J:71961
	abnormal vascular smooth muscle morphology	J:71961
	abnormal visceral yolk sac morphology	J:71961
	edema	J:71961
	enlarged pericardium	J:71961
	hemorrhage	J:71961, J:106055
	impaired fibroblast cell migration	J:71961
	lethality throughout fetal growth and development, complete penetrance	J:71961, J:106055
	pericardial edema	J:71961
	vascular smooth muscle hypoplasia	J:71961
S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal aorta smooth muscle morphology	J:106055
	abnormal cardiovascular system morphology	J:86450
	abnormal cardiovascular system physiology	J:86450
	abnormal limb morphology	J:86450
	abnormal pericardial cavity morphology	J:86450
	abnormal visceral yolk sac morphology	J:86450
	hemorrhage	J:86450
	lethality throughout fetal growth and development, complete penetrance	J:86450
	poor arterial differentiation	J:86450
S1pr1^tm2Rlp/S1pr1^tm2Rlp involves: 129S6/SvEvTac	no abnormal phenotype detected	J:86450

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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